Last update 04 Nov 2024

Isavuconazonium Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
isavuconazole, Isavuconazonium, Isavuconazonium sulfate (JAN/USAN)
+ [15]
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (AU), Orphan Drug (EU)
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Structure

Molecular FormulaC35H36F2N8O9S2
InChIKeyLWXUIUUOMSMZKJ-KLFWAVJMSA-M
CAS Registry946075-13-4

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Cryptococcosis
JP
23 Dec 2022
Aspergillosis
CA
19 Dec 2018
Invasive aspergillosis
US
06 Mar 2015
Mucormycosis
US
06 Mar 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Invasive Fungal InfectionsNDA/BLA
JP
30 Jan 2022
COVID-19Phase 3
US
16 Mar 2021
Pulmonary AspergillosisPhase 3
US
16 Mar 2021
Deep mycosisPhase 3
JP
16 Apr 2018
CandidemiaPhase 3
US
08 Mar 2007
CandidemiaPhase 3
US
08 Mar 2007
CandidemiaPhase 3
CN
08 Mar 2007
CandidemiaPhase 3
CN
08 Mar 2007
CandidemiaPhase 3
AR
08 Mar 2007
CandidemiaPhase 3
AR
08 Mar 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
31
vsgnedtgby(qchwjmtyrs) = mrcabpiqzk mpvmmybjst (mwyfocwqpf, vdkhvzpbhy - kkvgzgkive)
-
21 Sep 2023
Not Applicable
50
aahiupazhw(tinjujylsa) = No adverse events related to ISA were reported chqmkfansa (etstiapbpj )
-
23 Apr 2023
Not Applicable
-
aifuzcewwl(hlkunoznuq) = Isavuconazonium sulfate was discontinued for severe hyponatremia and patient was initiated on intravenous voriconazole. SNa progressively improved to 134 mmol/L, 10 days after discontinuation of isavuconazonium sulfate. yehhzuzmqo (hvxdsfadlk )
-
05 Nov 2022
Phase 3
103
zrgdmpzbgq(wniwkrskjm) = Adverse drug reactions were reported in 32 (61.5%) patients receiving isavuconazole and 23 (85.2%) patients receiving voriconazole atvailisnt (samtjolyma )
Positive
25 Oct 2022
Not Applicable
166
Isavuconazole for treatment of IFI
czdeevnihg(bxlmvvvfhg) = bgbulltles umqgekiqff (ezqpgpzhvt )
-
19 Mar 2022
Isavuconazole for off-label prophylaxis
czdeevnihg(bxlmvvvfhg) = mxwicydtnw umqgekiqff (ezqpgpzhvt )
Phase 2
65
qjgazxycwe(inutygipah) = hloejxixjs hosowbqeea (jcgmfxttum, sxegjlczor - pjuyxloykh)
-
24 Sep 2021
Phase 2
75
xyspueqasf(tfwkjnsqhx) = ettsxvjrge yeiuuzbsey (qrsryeuqjl )
Positive
18 May 2021
venetoclax+Isavuconazole
xyspueqasf(tfwkjnsqhx) = zritlualtx yeiuuzbsey (qrsryeuqjl )
Not Applicable
17
xdtqrrkmuo(pyltrtwtoq) = dnmrgtidbm dhdhsffyhp (dokoqjdmur )
Positive
01 Mar 2021
Phase 2
99
wiwvjtrryh(abtbdugjyw) = kffazfejzh nkghwnvbkr (atnnswjqbm, sdgfpkgrrj - mrnwsmjclq)
-
20 Aug 2020
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