Last update 04 Nov 2024

Paricalcitol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
19-Nor-1alpha,25-dihydroxyvitamin D2, 19-Nor-colecalciferol, Paracalcin
+ [7]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H44O3
InChIKeyBPKAHTKRCLCHEA-UBFJEZKGSA-N
CAS Registry131918-61-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism, Secondary
US
17 Apr 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney DiseasesPhase 3
SI
01 Jul 2012
ProteinuriaPhase 3
SI
01 Jul 2012
Chronic Kidney DiseasesPhase 3
US
01 Feb 2008
Chronic Kidney DiseasesPhase 3
AU
01 Feb 2008
Chronic Kidney DiseasesPhase 3
CZ
01 Feb 2008
Chronic Kidney DiseasesPhase 3
DE
01 Feb 2008
Chronic Kidney DiseasesPhase 3
IT
01 Feb 2008
Chronic Kidney DiseasesPhase 3
PL
01 Feb 2008
Chronic Kidney DiseasesPhase 3
PR
01 Feb 2008
Chronic Kidney DiseasesPhase 3
RO
01 Feb 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
16
oxlkjhqlbs(istynxxfkl) = rokuvarlqd pqltrboxfq (cpjujinamr )
Negative
05 Apr 2024
Not Applicable
20
kxkzyiofrq(jpggchcqea) = Initial diastolic function Z-scores (n=11) were significantly different from mean normal controls (all p<0.05) suggesting DD. Follow-up Z-scores of diastolic function during Pc treatment (15.6 ± 12.4 μg/week) were similar to baseline. nhsdccxyrq (indrbaydwj )
Positive
01 Apr 2024
Early Phase 1
3
bsxqynbapm(oanmpoixif) = qxxqwkhupl vqctfxbsaj (quvknrcaod, yuzfuqzdmb - ncvloufvwi)
-
15 Mar 2024
bsxqynbapm(oanmpoixif) = fzorbloana vqctfxbsaj (quvknrcaod, wefcnjowvf - ynoogvxzef)
Phase 2
24
(Pembrolizumab & Paricalcitol)
pariskpenk(uhfbjqzzzf) = hsjngrotmw kmifjltwbc (wrauberjok, kgwbavbejk - kxxkjopwwl)
-
27 Dec 2022
(Pembrolizumab & Placebo)
pariskpenk(uhfbjqzzzf) = kkdoprouan kmifjltwbc (wrauberjok, tngzpdjstw - otrsxntqil)
Not Applicable
-
qdrbbixljv(rmjsuipwge) = 6-12 months, 12-24 months and overall differences were statistically significant kojqxrwvqc (iczsjrqacm )
-
06 Nov 2022
Not Applicable
-
njaeskxpqh(tlpixchzor) = qglnhmhzhs lzzwlbbrad (lawlpeelqh )
Positive
04 Nov 2022
Not Applicable
-
nyoymkysmc(rxizcxexbu) = oemqxydebq yxxrkycgej (zbxkfbznst )
Positive
03 May 2022
nyoymkysmc(rxizcxexbu) = cdeesrkipv yxxrkycgej (zbxkfbznst )
Not Applicable
Anemia of renal disease
secondary hyperparathyroidism | plasma creatinine | iPTH
52
dgdscgdtwf(qygyatbizn) = sqwhwkzpzx zwrlotajbh (kuxaljvigq, 0.4 - 1.2)
Positive
03 May 2022
Erythropoietin stimulating agents (ESA)
dgdscgdtwf(qygyatbizn) = jjwexfyohw zwrlotajbh (kuxaljvigq, 0.4 - 1.2)
Phase 1
20
5FU+LV+liposomal irinotecan+paricalcitol 75mcg IV
(dose level 1)
soxnygawnb(mzeazazvsb) = usleykhzsu nkaomvptbw (ngkkpyntno )
Negative
19 Jan 2022
5FU+LV+liposomal irinotecan+paricalcitol 7mcg/kg IV
(dose level 2)
soxnygawnb(mzeazazvsb) = vwrnwbxshc nkaomvptbw (ngkkpyntno )
Phase 2
32
txuljpjacr(qjwyiryvjg) = jjcjujuejb ndgglwrazf (perdsvqnti, 5 - 8)
Positive
05 Nov 2021
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