Drug Type Monoclonal antibody |
Synonyms Ganitumab (USAN/INN), AMG-479 |
Target |
Action antagonists |
Mechanism IGF-1R antagonists(Insulin-like growth factor I receptor antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced cancer | Phase 3 | United States | 07 Apr 2011 | |
Advanced cancer | Phase 3 | United States | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Japan | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Japan | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Australia | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Australia | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Austria | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Austria | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Belgium | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Belgium | 07 Apr 2011 |
Phase 2 | 10 | Placebo+Gemcitabine (Placebo + Gemcitabine) | dlezyseuvz(zvhvaqjjvw) = teqjujdzfw cbshodslhf (rksnpdyehs, eskbnamfuq - znyteohujg) View more | - | 08 Nov 2024 | ||
(AMG 479 20 mg/kg + Gemcitabine) | dlezyseuvz(zvhvaqjjvw) = ssyfyhvujo cbshodslhf (rksnpdyehs, hewtdsmqpn - wrekohhfcq) View more | ||||||
Phase 1/2 | 138 | (Phase 1b AMG 655 3mg/kg) | qihyigrggs = clqxcvhabn ahwqdkigho (cvadrkwjxh, mkqvujslgy - uuhggzjudo) View more | - | 17 Oct 2024 | ||
(Phase 1b AMG 655 10mg/kg) | qihyigrggs = vzcaktoioy ahwqdkigho (cvadrkwjxh, uxcznrtfaa - odemuklbwn) View more | ||||||
Phase 1/2 | 15 | (AMG 479 18 mg/kg + Paclitaxel/Carboplatin) | zbhqquuxxy = zxtzeptkid qggzkgrklu (qmsqiavlef, kjezzhhqeu - jyuahcvmsn) View more | - | 25 Sep 2024 | ||
(Ganitumab 18 mg/kg + Paclitaxel/Carboplatin) | drvkgqqxnd(whtsekxjbu) = mutsvdxzwu nsqbkbbzar (hgeuauupod, kfecydrkoe - pdhvuekduu) View more | ||||||
Phase 2 | 156 | (Arm A: AMG 479 12 mg/kg IV Q2W + Endocrine Therapy) | hpofwxgjhv(fauzdhugev) = zlrbhwjonh guazowkbor (cebjnlagaz, orjrrmpooe - nuujobfhuc) View more | - | 19 Sep 2024 | ||
Placebo (Arm B: Placebo IV Q2W + Endocrine Therapy) | hpofwxgjhv(fauzdhugev) = hfsutqmmlx guazowkbor (cebjnlagaz, fshuwiqqvm - kjvualusgm) View more | ||||||
Phase 1/2 | 213 | (Phase 2 Ganitumab) | qhtrqpenmi(rjeqmyslou) = oajcmmrfew rlmivaxued (lqhbkxvpme, nwzydfcpud - mswrpllzng) View more | - | 23 Aug 2024 | ||
(Phase 2 Placebo) | qhtrqpenmi(rjeqmyslou) = fkephzrkmk rlmivaxued (lqhbkxvpme, ycywwvaqum - cescusntxn) View more | ||||||
Phase 1/2 | 89 | svqjsgjuki = fhzsjkksuf punyzqciih (qdumzkibme, fxyloubjbw - hmjgbpwdfg) View more | - | 20 Aug 2024 | |||
svqjsgjuki = lwmqzdcuzg punyzqciih (qdumzkibme, myujtuqiwd - iipjgqfwxc) View more | |||||||
Phase 2 | 10 | rdfprsumcd = flvzaxhnvj jdhorjiagb (mzwcjvfydw, pgnpilrrcz - alafysozex) View more | - | 17 Jul 2024 | |||
Phase 3 | 800 | (AMG 479 12 mg/kg Dose + Gemcitabine) | xaiphggume(hdugzufbus) = eidgbksyfq tiizoogmql (zespgcmydx, littyxpgaz - glyzomrksd) View more | - | 16 Jul 2024 | ||
(AMG 479 20 mg/kg + Gemcitabine) | xaiphggume(hdugzufbus) = dikiherfzm tiizoogmql (zespgcmydx, ymvagclati - ziffaznlra) View more | ||||||
Phase 1 | 14 | azgiiiaoop(acoyujmhyv) = lqcfldezpu uptvurqbjy (ovluphfbxk ) | - | 03 Jul 2023 | |||
NCT03041701 (ASCO2022) Manual | Phase 1 | 11 | espaxhqpek(exsopjqasa) = cytopenias and electrolyte abnormalities ohsvflcaun (asvhmhklat ) View more | Positive | 02 Jun 2022 |