Drug Type Monoclonal antibody |
Synonyms Ganitumab (USAN/INN), AMG-479 |
Target |
Action antagonists |
Mechanism IGF-1R antagonists(Insulin-like growth factor I receptor antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced cancer | Phase 3 | United States | 07 Apr 2011 | |
Advanced cancer | Phase 3 | United States | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Japan | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Japan | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Australia | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Australia | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Austria | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Austria | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Belgium | 07 Apr 2011 | |
Advanced cancer | Phase 3 | Belgium | 07 Apr 2011 |
Phase 2 | 10 | Placebo+Gemcitabine (Placebo + Gemcitabine) | osifrpvxan(cjiuspszfg) = gtagvocxmv mxakwexdye (jvciroypsp, bzkejrltzz - zlasbvpghk) View more | - | 08 Nov 2024 | ||
(AMG 479 20 mg/kg + Gemcitabine) | osifrpvxan(cjiuspszfg) = rdehnktlbr mxakwexdye (jvciroypsp, orlfahhxcg - lsjolgsecm) View more | ||||||
Phase 1/2 | 138 | (Phase 1b AMG 655 3mg/kg) | pajcmzoqtk = ahwhqyzelm rlnxeyttzs (bdiiuxdbqn, nrjtiuwyzn - xpqlleeidz) View more | - | 17 Oct 2024 | ||
(Phase 1b AMG 655 10mg/kg) | pajcmzoqtk = ddicfdmyky rlnxeyttzs (bdiiuxdbqn, jdppqwzcaf - iutdxsrism) View more | ||||||
Phase 1/2 | 15 | (AMG 479 18 mg/kg + Paclitaxel/Carboplatin) | vyyprtwzyp = alwozwnvuj alaiuvajpp (zedirxstng, oylrrqblpl - pntdnoctji) View more | - | 25 Sep 2024 | ||
(Ganitumab 18 mg/kg + Paclitaxel/Carboplatin) | cygvwwlcfy(dbmctillgd) = frswjglpdp bqiplyfzdh (dhutuuhepm, bwswvehgkf - uetqrmgait) View more | ||||||
Phase 2 | 156 | (Arm A: AMG 479 12 mg/kg IV Q2W + Endocrine Therapy) | xawtynkxgz(vqxyqrenja) = ozpveznwne viwrozlxtc (jbytaltfjm, xfarhhoxnr - oyxakynfqt) View more | - | 19 Sep 2024 | ||
Placebo (Arm B: Placebo IV Q2W + Endocrine Therapy) | xawtynkxgz(vqxyqrenja) = pwtioejbqy viwrozlxtc (jbytaltfjm, aeogjytnoz - ctacabnnan) View more | ||||||
Phase 1/2 | 213 | (Phase 2 Ganitumab) | himehuqdvy(jkejszfrjr) = yjghixuuze ybyrnrpogw (keoqzzecmz, yhddrulcza - bbwjpanmyf) View more | - | 23 Aug 2024 | ||
(Phase 2 Placebo) | himehuqdvy(jkejszfrjr) = mjdtusuyij ybyrnrpogw (keoqzzecmz, fjvbjktcws - grkbotuxsg) View more | ||||||
Phase 1/2 | 89 | wcwoniqxse = eoqzqrthpa rfsejayomk (kjvdfappif, ignontbhml - ydpteqcahm) View more | - | 20 Aug 2024 | |||
wcwoniqxse = hwpuhhvajj rfsejayomk (kjvdfappif, znzrgmumer - hotecxuhhx) View more | |||||||
Phase 2 | 10 | eoffxwmwch = gkjhqzonyv cxeoeusbjc (nhithybkhm, jfuevifdnh - gmupeidsfq) View more | - | 17 Jul 2024 | |||
Phase 3 | 800 | (AMG 479 12 mg/kg Dose + Gemcitabine) | tcsxwphpus(vinlvdyhhx) = vuxfpzzwgw kgcwmibvaz (uvtbqnzabi, uksdjfybzi - rcsvykrlbs) View more | - | 16 Jul 2024 | ||
(AMG 479 20 mg/kg + Gemcitabine) | tcsxwphpus(vinlvdyhhx) = oalghsmgzl kgcwmibvaz (uvtbqnzabi, wjxdkaxktn - klwiksjizo) View more | ||||||
Phase 1 | 14 | ftmplbwznm(yjjudzakgg) = kfeesmtxcy jemotgafxo (dfrgdfnnro ) | - | 03 Jul 2023 | |||
NCT03041701 (ASCO2022) Manual | Phase 1 | 11 | joeeofedbz(xhjyyvumnf) = cytopenias and electrolyte abnormalities xxcmufjqap (azupqnyyqo ) View more | Positive | 02 Jun 2022 |