Last update 20 Mar 2025

Metformin Hydrochloride/Pioglitazone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ACTOplus met, Competact, Glubrava
+ [14]
Action
agonists, activators
Mechanism
PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (29 Aug 2005),
Regulation-
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Structure/Sequence

Molecular FormulaC23H33Cl2N7O3S
InChIKeyQQPUCHJKWMHONF-UHFFFAOYSA-N
CAS Registry737811-27-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
29 Aug 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Discovery
Iceland
11 Dec 2007
Diabetes Mellitus, Type 2Discovery
Liechtenstein
11 Dec 2007
Diabetes Mellitus, Type 2Discovery
European Union
11 Dec 2007
Diabetes Mellitus, Type 2Discovery
Norway
11 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
98
(Pioglitazone and Metformin)
lxtuoysnbi(rvwsnwvzmx) = hsukdodoyh fyapvwhakj (oljmxrpbqm, evolujigbq - jsjcmvakau)
-
10 Jun 2014
Placebo
(Placebo)
lxtuoysnbi(rvwsnwvzmx) = wzvktpjiev fyapvwhakj (oljmxrpbqm, rwbrszhahh - qzpbbqcuwt)
Phase 3
305
(Pioglitazone 15 mg and Metformin 850 mg BID)
wysysuhsbl(ucenmcmrpl) = iobguvxenw ptqdoyjbal (wyyzjctokh, qmomjxmhcq - phrvludplq)
-
06 Oct 2010
(Glimepiride 2 mg and Metformin 850 mg BID)
wysysuhsbl(ucenmcmrpl) = hsvsbkrphw ptqdoyjbal (wyyzjctokh, goximshdae - yzcjyuzjgl)
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Regulation

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