Last update 04 Nov 2024
Amifostine
Last update 04 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Amifostine (USP), Amifostine anhydrous, Amifostine hydrate + [20] |
Target |
Mechanism TNSALP modulators(Alkaline phosphatase, tissue-nonspecific isozyme modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (08 Dec 1995), |
RegulationOrphan Drug (US), Accelerated Approval (US) |
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Structure
Molecular FormulaC5H21N2O6PS |
InChIKeyTXQPXJKRNHJWAX-UHFFFAOYSA-N |
CAS Registry112901-68-5 |
Related
32
Clinical Trials associated with AmifostineA Phase II Trial of Capecitabine and Irinotecan With or Without Amifostine in Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
A Combination Study to Evaluate the Safety and Efficacy of an Anticancer Medication (A01) With Immune Cells (IC01) in Subjects With Advanced Gastrointestinal Cancer
A Combination Study to Evaluate the Safety and Efficacy of an Anti-cancer Medication (A01) With Immune Cells (IC01) in Subjects With Advanced Solid Tumors
100 Clinical Results associated with Amifostine
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100 Translational Medicine associated with Amifostine
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100 Patents (Medical) associated with Amifostine
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1,821
Literatures (Medical) associated with Amifostine01 Dec 2024EJSO
Acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy - A systematic review
Review
Author: Solanki, Sohan Lal ; Kuberkar, Deepali V ; Kuberkar, Deepali V. ; Bhatt, Aditi ; Ambulkar, Reshma ; Salunke, Bindiya ; Gangakhedkar, Gauri
The use of nephrotoxic chemotherapeutic agents during hyperthermic intraperitoneal chemotherapy (HIPEC), carries the risk of postoperative acute kidney injury (AKI). The available evidence on this subject is sparse with variability in the reported incidence of AKI. In this systematic review, the aim was to analyse the incidence, risk factors, and preventive measures for AKI after cytoreductive surgery and HIPEC. A systematic literature search was conducted using the terms 'Acute kidney injury', 'Acute kidney failure', 'Acute renal failure', 'Acute renal impairment', 'HIPEC Surgery', 'Cytoreductive Surgery', 'Heated Chemotherapy' on PubMed, Scopus, clinical trial.gov, POPLINE and Google Scholar. Randomized controlled trials, cohort studies and observational studies published from January 2000-December 2020 were included. The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021247781). Data from 16 articles, which included 1622 patients, was included. The incidence AKI by any definition, was 23.36 %. The highest incidence of AKI (45.45 %) was reported after paclitaxel-HIPEC. The incidence of AKI after cisplatin-HIPEC was 34.7 %. Cisplatin HIPEC was the most common factor associated with AKI in 7/16 studies followed by pre-existing comorbidities and low intraoperative diuresis in 4 and 3 studies respectively. The perioperative use of sodium thiosulfate and amifostine led to a significant reduction in the incidence of AKI. The reported incidence of AKI after CRS-HIPEC is high. Identifying preoperative risk factors, optimising comorbidities, maintaining perioperative haemodynamic stability, perioperative use of sodium thiosulfate, maintaining adequate diuresis could reduce the incidence of AKI.
03 Oct 2024NEURO-ONCOLOGY
The cochlear dose and the age at radiotherapy predict severe hearing loss after passive scattering proton therapy and cisplatin in children with medulloblastoma
Article
Author: McAleer, Mary Frances ; Brown, Austin L ; Lindsay, Holly B ; Su, Jack M ; Abu-Arja, Mohammad H ; Chintagumpala, Murali M ; Paulino, Arnold C ; Grosshans, David R ; Okcu, M Fatih ; McGovern, Susan L
Abstract:
Background:
Hearing loss (HL) is associated with worse neurocognitive outcomes among patients with medulloblastoma. We aimed to identify risk factors associated with severe HL and to evaluate the generalizability of a published HL calculator among patients treated with passive scattering proton therapy (PSPT) and cisplatin.
Methods:
We identified patients aged 3–21 years who were treated at our centers between 2007 and 2022. Audiograms were graded using the International Society of Pediatric Oncology (SIOP) Boston scale. Time to grades 3–4 HL was evaluated using Kaplan–Meier and multivariable Cox models to estimate hazard ratios and 95% confidence intervals (CI).
Results:
Seventy-nine patients were treated with PSPT at a median age of 7.5 years (range: 3.1–21.1). The mean cochlear dose (Dmc) (±SD) was 31.5 ± 8.5 Gy, and the cumulative cisplatin dose was 295 ± 50 mg/m2. Fifty-nine patients (75%) received amifostine. Patients completed a median of 9 audiograms (range: 4–22) with a median audiogram follow-up of 49 months (range: 6–177). Twenty-seven patients (34%) had grades 3–4 HL. In adjusted Cox models, only higher Dmc (HR = 1.12, 95% CI:1.06–1.18) was associated with grades 3–4 HL. The predicted 3-year incidence of grades 3–4 HL was 40.0% (95% CI: 21.3–66.3) and 66.7% (95% CI: 35.4–93.7) for children with Dmc ≥36 Gy and age at radiotherapy ≥7 and <7 years, respectively (P = .042). It was 8.9% (95% CI: 2.3–31.6) and 15.6% (95% CI: 5.3–41.1) for children with Dmc <36 Gy and age at radiotherapy ≥7 and <7 years, respectively (P = .78).
Conclusions:
Children <7 years at radiotherapy with a Dmc ≥36 Gy are at higher risk for HL.
10 Sep 2024MOLECULAR MEDICINE
N-formylmethionine-leucyl-phenylalanine protects against irradiation-induced damage to hematopoiesis and intestines.
Article
Author: Du, Jicong ; Wang, Sinian ; Qian, Wen ; Li, Fengsheng ; Jiao, Shunchang ; Li, Zhihua ; Dong, Suhe ; Wu, Yatong
BACKGROUND:
Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses. Thankfully, an LPS analogue called N-formylmethionine-leucyl-phenylalanine (fMLP) holds the potential to mitigate this toxicity, offering hope for radiation protection.
METHODS:
Survival of C57BL/6 mice exposed to IR after administration with fMLP/LPS/WR-2721 or saline was recorded. Cell viability and apoptosis assay of bone marrow (BMC), spleen and small intestinal epithelial (HIECs) cells were tested by Cell Counting Kit-8 (CCK-8) and flow cytometry assay. Tissue damage was evaluated by Hematoxilin and Eosin (H&E), Ki-67, and TUNEL staining. RNA sequencing was performed to reveal potential mechanisms of fMLP-mediated radiation protection. Flow cytometry and western blot were performed to verify the radiation protection mechanism of fMLP on the cell cycle.
RESULTS:
The survival rates of C57BL/6 mice exposed to ionizing radiation after administering fMLP increased. fMLP demonstrated low toxicity in vitro and in vivo, maintaining cell viability and mitigating radiation-induced apoptosis. Moreover, it protected against tissue damage in the hematopoietic and intestinal system. RNA sequencing shed light on fMLP's potential mechanism, suggesting its role in modulating innate immunity and cell cycling. This was evidenced by its ability to reverse radiation-induced G2/M phase arrests in HIECs.
CONCLUSION:
fMLP serves as a promising radioprotective agent, preserving cells and radiosensitive tissues from IR. Through its influence on the cell cycle, particularly reversing radiation-induced arrest in G2/M phases, fMLP offers protection against IR's detrimental effects.
2
News (Medical) associated with Amifostine11 Aug 2023
AcquisitionLicense out/in
10 Aug 2023
AcquisitionRadiation Therapy
100 Deals associated with Amifostine
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00226 | Amifostine |
R&D Status
Approved
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Cytoprotective Agent | CN | 01 Jan 2001 | |
| Neutropenia | AU | 16 Apr 1998 | |
| Xerostomia | AU | 16 Apr 1998 | |
| Chemotherapy-induced damage | US | 08 Dec 1995 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Head and Neck Neoplasms | Phase 3 | FR | 01 Mar 2001 | |
| Acute Myeloid Leukemia | Phase 2 | US | 01 Jul 2004 | |
| Acute Myeloid Leukemia | Phase 2 | IL | 01 Jul 2004 | |
| Esophagitis | Phase 2 | US | 01 Nov 2003 | |
| Pneumonia | Phase 2 | US | 01 Nov 2003 | |
| Unresectable Lung Non-Small Cell Carcinoma | Phase 2 | US | 01 Nov 2003 | |
| Hodgkin's Lymphoma | Phase 2 | US | 01 May 2003 | |
| Non-Hodgkin Lymphoma | Phase 2 | US | 01 May 2003 | |
| Locally Advanced Head and Neck Squamous Cell Carcinoma | Phase 2 | US | 01 May 2002 | |
| Locally Advanced Cervical Carcinoma | Phase 1 | US | 29 Aug 2005 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 2 | 4 | vbnuqrclsm(yxzveubacj) = vpodgsvsyg kwvsnldeyh (cnibalcftm, khljwnktky - oocgldbhch) View more | - | 01 Aug 2023 | |||
Phase 2 | 2 | soxszccujy(ibsnrqkvmu) = ikononknbv rcswrtgtnb (aqlwocahue, beixcxgohi - byfiwnodcb) View more | - | 25 Jan 2022 | |||
Phase 3 | 17 | CyberKnife stereotactic radiosurgery (Placebo) | efnuxhenwp(teltpebqrh) = mivrkqvrcf fsuhiybjcn (vgrtbtevet, mbpbirtvrf - wbimmdbzcf) View more | - | 04 Apr 2017 | ||
(Amifostine) | efnuxhenwp(teltpebqrh) = hlalluuipy fsuhiybjcn (vgrtbtevet, xuyjssupld - ducdsichxt) View more | ||||||
Phase 2 | 21 | voxpqqtoan(olkjrwszvh) = kuwhyiengp yapagphxul (jloqlfvpcb, dvypdjeway - rcflvscqjb) View more | - | 08 Aug 2016 | |||
Phase 2 | 3 | Intensity- Modulated Radiation Therapy+Amifostine | wlwhfotqij(gwapcxpzay) = lohjexgrqq fupssfqfxq (tvmddhvzdq, ztwtxssgbs - jwbxrmdaof) View more | - | 18 Jan 2010 | ||
Phase 2 | 58 | emzzbxodvl(doqdyiasnq) = tzqjeygjaa fgmkxuduia (qradfiphao ) | - | 01 Oct 2009 | |||
Not Applicable | 243 | qspgbxwhoh(isaolzrrms) = cvmafmqthc nmvbwxipkq (hkpiyjytjv ) | - | 20 Jun 2007 | |||
qspgbxwhoh(isaolzrrms) = qfognyvrot nmvbwxipkq (hkpiyjytjv ) | |||||||
Phase 1 | 42 | ujfjbxewjv(ekwxwcpyus) = mzpwfwcnkq sgkljguhdk (zjynnswlik ) View more | - | 20 Jun 2007 | |||
Not Applicable | - | - | Amifostine 740 mg/m^2 | nitrpzjigy(nhpynpeknw) = gtbperoxqi bemffugdxo (eeubihjthz ) | - | 01 Feb 2006 | |
IVBU and CP | nitrpzjigy(nhpynpeknw) = zciqvvippn bemffugdxo (eeubihjthz, 6340) | ||||||
Not Applicable | - | gzgyqaymzc(kxdqoycmfm) = izktpblcjp ecmapexqgb (pljdtvttmb ) View more | - | 01 Jun 2005 |
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