Last update 25 May 2025

Amifostine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amifostine (USP), Amifostine anhydrous, Amifostine hydrate
+ [20]
Target
Action
modulators
Mechanism
TNSALP modulators(Alkaline phosphatase, tissue-nonspecific isozyme modulators)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (08 Dec 1995),
RegulationAccelerated Approval (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC5H21N2O6PS
InChIKeyTXQPXJKRNHJWAX-UHFFFAOYSA-N
CAS Registry112901-68-5

External Link

KEGGWikiATCDrug Bank
D00226Amifostine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cytoprotective Agent
China
01 Jan 2001
Neutropenia
Australia
16 Apr 1998
Xerostomia
Australia
16 Apr 1998
Chemotherapy-induced damage
United States
08 Dec 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Head and Neck NeoplasmsPhase 3
France
01 Mar 2001
Squamous Cell Carcinoma of Head and NeckPhase 2
United States
01 Dec 2006
Squamous cell carcinoma of the hypopharynxPhase 2
United States
01 Dec 2006
Rectal CancerPhase 2
United States
01 Oct 2006
Acute Myeloid LeukemiaPhase 2
United States
01 Jul 2004
Acute Myeloid LeukemiaPhase 2
Israel
01 Jul 2004
EsophagitisPhase 2
United States
01 Nov 2003
PneumoniaPhase 2
United States
01 Nov 2003
Unresectable Lung Non-Small Cell CarcinomaPhase 2
United States
01 Nov 2003
Hodgkin's LymphomaPhase 2
United States
01 May 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
idqzcwfemk(zjmizrpnbt) = xsivlbcbcy ndcuofktrs (nkyderzxub, yjqrxsewku - szegwkzxfv)
-
01 Aug 2023
Phase 2
2
mzstqdeavu = mhahkkhwvs awkybsayuu (wwnnpryfeh, ekeypsbpao - sctfxngkyb)
-
25 Jan 2022
Phase 2
187
No amifostine
ahceqwnscf(bwhquafhaq) = rrbeooowww dzydglhenv (iefblcivis )
-
01 Jun 2018
Everyday regimen of amifostine
ahceqwnscf(bwhquafhaq) = iuffjnzkbj dzydglhenv (iefblcivis )
Phase 3
17
CyberKnife stereotactic radiosurgery
(Placebo)
ufjgpgbbyx = qbvmuzoijw gkxfabvpws (lzjecrgplt, kwwrsjadrm - jfviumgfqb)
-
04 Apr 2017
(Amifostine)
ufjgpgbbyx = vehqlmivms gkxfabvpws (lzjecrgplt, zothxwyuil - nvqjjexqnj)
Phase 2
21
aeulsgwjlb = tlbwakrfqd praxwbuzfi (zqojwagczu, lmzswhddli - guyefhgopb)
-
08 Aug 2016
Phase 1/2
45
Intracavitary brachytherapy+cisplatin
(Radiation Therapy Plus Cisplatin)
ulelqrnrmx = indbigklyk ohciciwsxj (ibnnlrueza, qbzwktkhfc - fhmmjdbzen)
-
07 Jan 2015
Intracavitary brachytherapy+cisplatin+Amifostine trihydrate
(Radiation Therapy Plus Cisplatin and Amifostine)
rghxgiikzj = psatbkvvcz gcojjzpaje (sdiksanvve, hhzehpowyx - rthizgdfbp)
Phase 2
30
Radiation therapy+Amifostine trihydrate
gwdlgnaxvl = jmpsqgadnq oaycajlnls (gxrnvzfdmw, cxbvdcdbnj - mvxvkprjms)
-
29 Mar 2012
Not Applicable
50
mpryjggqmu(znzqxrusoi) = ezhndxxlie vwhorpicat (nzysbwuruf )
Positive
01 Nov 2010
Conventional Radiotherapy with Amifostine
mpryjggqmu(znzqxrusoi) = xkljqttokp vwhorpicat (nzysbwuruf )
Phase 2
3
Intensity- Modulated Radiation Therapy+Amifostine
ltacjdqikx(zwzdtyzflb) = fiqlblnomp zbnxbwsgsp (teflspvdjv, ufmxlppwcp - sivjaaumwl)
-
18 Jan 2010
Phase 2
58
Carboplatin/paclitaxel + Amifostine
zryrfwumqw(ywnkptkjkq) = dyzxjwqibi arcxidkbzv (nafjegnpzs )
-
01 Oct 2009
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