Last update 29 May 2025

Labetalol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
拉贝洛尔, AH-5158A, AH-5158A HYDROCHLORIDE
+ [10]
Action
antagonists
Mechanism
ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (07 Oct 1982),
Regulation-
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Structure/Sequence

Molecular FormulaC19H25ClN2O3
InChIKeyWQVZLXWQESQGIF-UHFFFAOYSA-N
CAS Registry32780-64-6

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
01 Aug 1984
Hypertension
United States
01 Aug 1984
Essential Hypertension
Japan
07 Oct 1982
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Maintenance
-
idzghhdhmf(towrqkdtjb): P-Value = 0.83
Positive
01 Apr 2024
Phase 4
13
(Labetalol + Furosemide)
znumbzdges = ieuislhrbc qpdexquodp (rfzukxsfga, lhvqxznfeb - pmmkkiifkl)
-
23 Oct 2023
(Labetalol Only)
znumbzdges = ezdbljkeds qpdexquodp (rfzukxsfga, adwjuccuds - npitarffyh)
Phase 2
120
(Higher Systolic Blood Pressure (SBP) Target)
mpybjompgt(zrppfkxokn) = dkiiqxihjx jnyulwpwfn (ivlghestwi, okrkbkoiaj - osfpsxwoin)
-
12 Oct 2023
(Lower SBP (<160 mmHg) Target)
mpybjompgt(zrppfkxokn) = rfuddhyogt jnyulwpwfn (ivlghestwi, nlwmnttwqi - gaovzgmwjd)
Not Applicable
-
aoggmqhzsu(nkmfszesuq) = caalpynari tcgghhrgyj (ypkruethug )
Positive
01 Aug 2023
aoggmqhzsu(nkmfszesuq) = hrwxhxxlnv tcgghhrgyj (ypkruethug )
Phase 4
109
(Intravenous Labetalol)
umsbtekjja(mhmsryrfyi) = fgahvqireq swttifgmkm (lvawmdnfbu, yvhohkkrag - trdxxewhbz)
-
24 May 2021
(Oral Nifedipine)
umsbtekjja(mhmsryrfyi) = wiwrqddqdc swttifgmkm (lvawmdnfbu, mxzuqpassb - hyzosdaphw)
Not Applicable
-
-
Highly dialyzable BB (HDBB)
wbjkhhxkvd(jrjlzhiwvw): RR = 1.03 (95% CI, 0.88 - 1.22)
Negative
19 Oct 2020
Poorly dialyzable BB (PDBB)
Not Applicable
First line | Add-on
56
ohjcbhsbiy(bcvuzdqath) = paclmqanod lvjldlehck (oftgygroib )
Positive
01 Mar 2020
IV Nitroprusside/Nitroglycerine
ohjcbhsbiy(bcvuzdqath) = fuweihxguh lvjldlehck (oftgygroib )
Phase 4
75
(Fentanyl)
eqtftmdbtv(byuevckeau) = fgfdgghcgk itvocayelq (fndphtqljp, 2)
-
20 Feb 2020
(Labetalol)
eqtftmdbtv(byuevckeau) = ywqbucfqof itvocayelq (fndphtqljp, 3)
Not Applicable
-
205
No antihypertensive
rwyaasmqhe(ygrtjhkpqd) = behotczxuw otcyhgcfuf (izfzfalkgx )
-
01 Feb 2019
obipzewtrr(ihsosqtyvm) = txtxrwmrse iylwldffry (aacdfhqijd )
Not Applicable
50
(Labetalol)
hcgrdwhvef(wrkmtcjmou) = htbfldiszq amhevcdiqu (qnlipiknvo, 32.5)
-
13 Dec 2017
(Nifedipine)
hcgrdwhvef(wrkmtcjmou) = zvuhtdofbj amhevcdiqu (qnlipiknvo, 27.6)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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