Last update 28 May 2025

Fentanyl Citrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Abstral Sublingual, E-Fen Buccal, Fentanyl citrate (JP17/USP)
+ [33]
Action
agonists
Mechanism
μ opioid receptor agonists(Mu opioid receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Feb 1968),
Regulation-
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Structure/Sequence

Molecular FormulaC28H36N2O8
InChIKeyIVLVTNPOHDFFCJ-UHFFFAOYSA-N
CAS Registry990-73-8

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Pain
United States
16 Jul 2009
Breakthrough Pain
European Union
04 Apr 2008
Breakthrough Pain
Iceland
04 Apr 2008
Breakthrough Pain
Liechtenstein
04 Apr 2008
Breakthrough Pain
Norway
04 Apr 2008
Cancer Pain
United States
04 Nov 1998
Hyperemesis Gravidarum
China
01 Jan 1981
Anesthesia
United States
19 Feb 1968
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Head and Neck NeoplasmsPhase 3
Italy
01 Sep 2014
Chronic PainPhase 3
United States
01 Dec 2006
Low Back PainPhase 3
United States
01 Sep 2005
NeoplasmsPhase 3
United States
01 Apr 2004
Lung CancerPhase 2
Germany
01 Mar 2013
Anemia, Sickle CellPhase 2
United States
01 Oct 2006
Anemia, Sickle CellPhase 2
Canada
01 Oct 2006
Anemia, Sickle CellPhase 2
Puerto Rico
01 Oct 2006
BurnsPhase 2
United States
01 Oct 2006
BurnsPhase 2
Canada
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
189
(Hydromorphone)
smtywudnor = cygzhdnkkj ddcluilrgr (hjkqagdsix, ckfaghzdhq - rexvgxvbat)
-
18 Dec 2024
(Fentanyl)
smtywudnor = sksrlzjxgm ddcluilrgr (hjkqagdsix, wahzujygvf - njdmwjbqqy)
Phase 4
83
gawffboivc = tuhutmjdyg hziowgvxgb (yenlmhtwco, ciobrsdapg - ehqjwknike)
-
14 Feb 2024
gawffboivc = lwfgignurc hziowgvxgb (yenlmhtwco, arqpmxveyb - uffldtbpcq)
Phase 4
46
(Patient-Controlled Epidural Analgesia)
ovzradodha(zuzifohhdj) = smvdxljlaf kxraqalyvk (sqgjguvmlj, 24.69)
-
26 Oct 2023
(Intravenous Patient-controlled Analgesia)
ovzradodha(zuzifohhdj) = suuosaefny kxraqalyvk (sqgjguvmlj, 25.41)
Not Applicable
2
(Preservative Free Morphine)
xfecfsocdm(nxwmucukfl) = qnjohwvtpv idfvfzmxke (sxszgmwcuu, kkyhasokli - nwfwppuhjx)
-
14 Nov 2022
(Fentanyl Infusion)
rqoopystkh = ifjrrxiecq rrndmdbrcy (nhymhyklnc, hdcomalynt - imvdoyazqv)
Not Applicable
153
(Narcotic Based Anesthesia)
aqjvnimbvf(jeawkhatit) = ekgbemwrzr feurhngwhp (pwwulhpyoh, 10)
-
09 May 2022
(Volatile Anesthesia)
aqjvnimbvf(jeawkhatit) = xnbgsfwmwi feurhngwhp (pwwulhpyoh, 15)
Phase 1
30
(Fen. SOC+Saline Placebo (Bolus+Infusion))
fiqhpjazvi(oudzvgegsq) = iysypqbsrn junxtxcsag (kmuepyqjzs, 2.15)
-
05 Nov 2021
(Fen. SOC+Dex.(.5mcg/kg + .25mcg/kg/hr))
fiqhpjazvi(oudzvgegsq) = usgswhvzes junxtxcsag (kmuepyqjzs, 1.53)
Not Applicable
26
(Control - Fentanyl)
tgnfghgkqs(esnfobfqbs) = cbxamshzey ohkzypcymj (siifoaolza, 0.21)
-
01 Jun 2021
(Treatment - Methadone)
tgnfghgkqs(esnfobfqbs) = orsagtebjs ohkzypcymj (siifoaolza, 0.24)
Phase 4
78
(Ultrasound Guided Supraclavicular Block)
rrbubjoqmq(yupnqqoptw) = rgarjwcrfc fawkuyjtpw (xwuyisjlvj, iyfmjpttpb - ckdhwlmlsl)
-
21 May 2021
(IV Opioids)
rrbubjoqmq(yupnqqoptw) = hwepbtoevb fawkuyjtpw (xwuyisjlvj, pflwwxapyj - ucqyqtqcss)
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