Last update 21 Nov 2024

Dexrazoxane Hydrochloride

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Topotect, Totect, dexrazoxane

+ [11]

Target

Top II

Mechanism

Top II inhibitors(Topoisomerase II inhibitors)

Therapeutic Areas

Other Diseases

Active Indication

Extravasation of Diagnostic and Therapeutic MaterialsCytoprotective Agent

Inactive Indication

BronchitisCardiomyopathiesHemorrhage+ [1]

Originator Organization

Clinigen Ltd.

Active Organization

Kissei Pharmaceutical Co., Ltd.

CNX Therapeutics Ltd.

Nanjing Hairun Pharmaceutical Co Ltd.

Inactive Organization

Valerio Therapeutics SA

Pfizer Inc.

Clinigen Ltd.

Drug Highest PhaseApproved

First Approval Date

US (26 May 1995),

CardiomyopathiesMetastatic breast cancer

RegulationOrphan Drug (US), Accelerated Approval (US)

Structure

Molecular FormulaC11H17ClN4O4

InChIKeyBIFMNMPSIYHKDN-FJXQXJEOSA-N

CAS Registry149003-01-0

View All Structures (2)

Clinical Trials associated with Dexrazoxane Hydrochloride

NCT06647953 / Not yet recruitingPhase 3IIT

Prospective Treatment of Types I, II and III Pleuropulmonary Blastoma (PPB)

This phase III trial tests how well surgery plus chemotherapy compared to surgery alone works in treating patients with type I pleuropulmonary blastoma (PPB), and tests how well surgery plus standard chemotherapy with the addition of topotecan works compared to surgery plus standard chemotherapy alone in treating patients with type II and III PPB.
Historically, most children with type I PPB had surgery and approximately 40% of children with type I PPB received chemotherapy following their surgery, usually for 22-42 weeks. There has not been a consistent standard for which children with type I PPB receive chemotherapy after surgery. For patients whose tumor has been removed completely with surgery, observation without chemotherapy may work as well as giving chemotherapy after surgery in preventing a return of the PPB tumor.
The standard chemotherapy for patients with types II or III PPB in the United States is four cycles of IVADo (ifosfamide, vincristine, dactinomycin, and doxorubicin) followed by 8 cycles of IVA (ifosfamide, vincristine and dactinomycin). Ifosfamide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of tumor cells in the body. Vincristine is in a class of medications called vinca alkaloids. It works by stopping tumor cells from growing and dividing and may kill them. Dactinomycin is a type of antibiotic that is only used in cancer chemotherapy (antineoplastic antibiotic). It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill tumor cells. Doxorubicin is in a class of medications called anthracyclines. Doxorubicin damages the cell's DNA and may kill tumor cells. It also blocks a certain enzyme needed for cell division and DNA repair. Topotecan is in a class of medications called topoisomerase I inhibitors. It works by interfering with tumor cell DNA which kills them. Giving topotecan in addition to standard IVADo and IVA chemotherapy regimens may shrink the cancer as well as or better than the standard therapy or could decrease the chance the tumor spreads while causing fewer side effects.

Start Date17 Dec 2024

Sponsor / Collaborator

The Children's Oncology Group Foundation, Inc.

NCT06220032 / RecruitingPhase 3IIT

ANTICIPATE: Prevention of ANThracycline-Induced Cardiac Dysfunction by Dexrazoxane In PATients With diffusE Large B-cell Lymphoma: a Phase III National Multicenter Prospective Randomized Open-label Trial

Patients treated for DLBCL are at high risk of developing AICD. This adverse event is characterized by irreversible damage to the heart muscle with a loss of cardiomyocytes and subsequent decline in cardiac pumping capacity. Thereby patients treated for this malignancy are at double the risk of developing symptomatic heart failure / cardiomyopathy when compared to the general population. This corresponds to a cumulative incidence of 5-10% within 5-years after receiving R-CHOP. In the elderly, an incidence of 26% has been reported after 8-years of follow-up. Among patients who die in complete remission, heart failure has been described to be one of the most important causes of death. ANTICIPATE aims to evaluate if dexrazoxane can prevent AICD in DLBCL patients and identify those at highest risk of AICD. Of all patients treated with anthracyclines in a first-line setting, DLBCL patients were chosen for this trial for two primary reasons. Firstly, these patients have a favourable oncological prognosis with a 5-year relative survival in the Netherlands of 64-78% in those aged 18-74 years increasing the importance of preventing long-term toxicity. Secondly, the cumulative anthracycline dose used for the treatment of DLBCL is higher than the dose used in breast cancer. The cumulative anthracycline dose is the most important risk factor for AICD known.

Start Date15 Aug 2024

Sponsor / Collaborator

Hemato-Oncologie voor Volwassenen Nederland

NCT06262438 / RecruitingPhase 2IIT

A Phase II, Single Arm, Open Label, Study on the Safety, Efficacy, Pharmacokinetics & Pharmacodynamics of Quizartinib + Chemotherapy and as Single-agent After High Dose Therapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients

The CHIP-AML22 Master protocol has the overall aim of increasing the cure rate in newly diagnosed pediatric de novo AML patients, while avoiding unnecessary toxicity. The linked Quizartinib trial (CHIP-AML22/Quizartinib) is a phase II, single arm, open label, study on the safety, efficacy, pharmacokinetics and pharmacodynamics of quizartinib in combination with chemotherapy and as single-agent after high dose therapy in newly diagnosed pediatric AML patients with a FLT3-ITD mutation and NPM1 wild-type.

Start Date06 Feb 2024

Sponsor / Collaborator

Princess Maxima Centre For Pediatric Oncology

[+1]

100 Clinical Results associated with Dexrazoxane Hydrochloride

100 Translational Medicine associated with Dexrazoxane Hydrochloride

100 Patents (Medical) associated with Dexrazoxane Hydrochloride

844

Literatures (Medical) associated with Dexrazoxane Hydrochloride

01 Dec 2024·Toxicology

Knock-down of FOXO3, GATA2, NFE2L2 and AHR promotes doxorubicin-induced cardiotoxicity in human cardiomyocytes

Article

Author: Faber, J G ; Asensio, J Ochoteco ; Caiment, F ; van den Beucken, T

Recent advances in cancer therapy have substantially increased survival rates among patients, yet the prolonged effect of current treatment regimens with anthracyclines (ACs) often include severe long-term complications, notably in the form of anthracycline-induced cardiotoxicity (AIC). Despite known associations between AC treatment and AIC, a comprehensive understanding of the underlying molecular pathways remains elusive. This gap is highlighted by the scarcity of reliable therapeutic interventions, with dexrazoxane being the sole FDA-approved drug to mitigate AIC risks. This study aims at elucidating the transcriptional response of human cardiomyocytes (hCMs) to AC exposure by analyzing a previously generated RNA-sequencing dataset of cardiac spheroids subjected to clinically relevant doses of ACs. The analysis revealed a robust transcriptional response identified across various time points. We aimed at identifying important transcription factors (TFs) mediating AIC by employing predictive algorithms to highlight key TFs for further experimental validation. Using shRNA constructs, we further assessed the impact of these TFs on hCM response to doxorubicin (DOX) and revealed that these TFs had a notable impact on hCM survival upon DOX exposure. TFs FOXO3, GATA2, AHR and NFE2L2 were further investigated for their role in AIC including cell viability, DOX uptake, DNA damage repair and induction of apoptosis through Cleaved-Caspase 3. Our study demonstrated that eliminating FOXO3 and GATA2 made hCMs more vulnerable to DOX and the lack of GATA2, NFE2L2 and AHR led to significantly higher intracellular levels of DOX. Additionally, FOXO3 played a role in the repair of hCM DNA damage as we observed markedly enhanced levels of CDKN1A. We also noted significant increases in DNA damage through COMET-assays when FOXO3, GATA2, NFE2L2 and AHR were absent. Furthermore, we investigated the clinical relevance by comparing our results with those from a study based on hiPSC-CMs derived from patients with doxorubicin-induced cardiotoxicity, identifying overlapping TFs and their regulatory roles in critical cellular processes like the cell cycle and DNA repair. This approach not only advances the understanding of the molecular mechanisms behind AIC but also opens possible windows for new therapeutic approaches to mitigate the negative side-effects from patient AC treatment.

01 Nov 2024·Biomedicine & Pharmacotherapy

Metformin-mediated protection against doxorubicin-induced cardiotoxicity

Article

Author: Li, Pu ; Dong, Jun-Min ; Zhen, Jie ; Chen, Wei ; Zhang, Chao ; Liu, Chen ; Sun, Ming-Li

BACKGROUNDA phase II clinical trial of metformin (MET) for the treatment of doxorubicin (DOX)-induced cardiotoxicity (NCT02472353) failed.OBJECTIVESThe aims of this study were to confirm MET-mediated protection against DOX-induced cardiotoxicity and its mechanism using H9C2 cells, and to establish a Wistar rat model of DOX-induced cardiotoxicity. Subsequently, Wistar rats were utilized to identify clinically relevant indicators for evaluating MET-mediated protection against DOX-induced cardiotoxicity, thereby facilitating early transition towards successful clinical trials.METHODSMET-mediated protection was assessed using cell viability and cytotoxicity experiments. Additionally, intramitochondrial reactive oxygen species (ROS) levels were measured using an ROS fluorescent probe (dihydroethidium) to confirm the oxidative stress mechanism. Eighteen Wistar rats were randomly allocated to the control, DOX, and DOX+MET groups; and the body weight, adverse drug reactions (ADRs), myocardial injury, cardiac function, oxidative stress, and histopathology of heart tissues were compared between groups.RESULTSH9C2 cells treated with MET/Dexrazoxane demonstrated dose-dependent protection against DOX-induced cardiotoxicity. The fluorescence intensity of H9C2 cells suggested DOX-induced cardiomyocyte toxicity and MET-mediated protection against DOX-induced cardiotoxicity. In vivo experiments confirmed that a rat model of DOX-induced cardiotoxicity was successfully established, but MET-mediated protection against DOX-induced cardiotoxicity was not demonstrated. This was attributed to insufficient energy intake because of ADRs, such as vomiting.CONCLUSIONSWe confirmed the MET-mediated protection against DOX-induced cardiomyocyte toxicity and its mechanism involving the inhibition of oxidative stress in vitro experiments. It is imperative to investigate the optimal conditions for MET-mediated protection against DOX-induced cardiotoxicity in vivo or clinical trials.

10 Sep 2024·Molecules (Basel, Switzerland)

Rational Design, Synthesis, Molecular Docking, and Biological Evaluations of New Phenylpiperazine Derivatives of 1,2-Benzothiazine as Potential Anticancer Agents.

Article

Author: Czyżnikowska, Żaneta ; Zaręba, Natalia ; Janek, Tomasz ; Kepinska, Marta ; Szczęśniak-Sięga, Berenika M

The aim of this study was to obtain new, safe, and effective compounds with anticancer activity since cancer is still the leading cause of mortality worldwide. The rational design of new compounds was based on the introduction of differentially substituted phenylpiperazines into the 1,2-benzothiazine scaffold as a reference for the structures of recent topoisomerase II (Topo II) inhibitors such as dexrazoxane and XK-469. The newly designed group of 1,2-benzothiazine derivatives was synthesized and tested on healthy (MCF10A) and cancer (MCF7) cell lines, alone and in combination with doxorubicin (DOX). In addition, molecular docking studies were performed both to the DNA-Topo II complex and to the minor groove of DNA. Most of the tested compounds showed cytotoxic activity comparable to doxorubicin, a well-known anticancer drug. The compound BS230 (3-(4-chlorobenzoyl)-2-{2-[4-(3,4-dichlorophenyl)-1-piperazinyl]-2-oxoethyl}-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide) showed the best antitumor activity with lower cytotoxicity towards healthy cells and at the same time stronger cytotoxicity towards cancer cells than DOX. Moreover, molecular docking studies showed that BS230 has the ability to bind to both the DNA-Topo II complex and the minor groove of DNA. Binding of the minor groove to DNA was also proven by fluorescence spectroscopy.

News (Medical) associated with Dexrazoxane Hydrochloride

11 Aug 2023

·www.pharmaceutical-technology.com

Clinigen clears out cancer therapies in line with latest growth strategy

Akosua Mireku @AkosuaMireku1 This action follows Clinigen’s January 2023 sale of its kidney cancer treatment Proleukin (aldesleukin) to Iovance Biotherapeutics. Credit: Volodymyr Maksymchuk via Shutterstock. UK-headquartered Clinigen announced the divestment of global rights for four of its cancer therapies from its portfolio, as per a 10 August press release. Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. 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Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address. Thank you. Please check your email to download the Report. The company gave away the rights of Cardioxane, Savene, Totect and Ethyol (amifostine), as Clinigen shifts its pharmaceutical strategy. The first three drugs use dexrazoxane to treat cardiotoxicity caused by cancer drugs while Ethyol is used to correct the effects of cancer treatment with cisplatin or radiation. Recommended Reports Reports Global Hematological Cancer (Blood Cancer) Therapy Market to 2027 - Comprehensive Overview of Mar... GlobalData Reports Hypopharyngeal Cancer Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Pla... GlobalData View all Companies Intelligence Iovance Biotherapeutics Inc Clinigen Inc CNX Therapeutics Ltd Drug Safety Navigator, LLC Lamda Laboratories SA View all Clinigen announced that the four drugs will join CNX Therapeutics’ pharmaceutical portfolio. Based in the UK, CNX Therapeutics commercialises and distributes pharmaceuticals in 40 countries globally. According to its website, the biotech is “seeking to expand its product portfolio in Europe and selected global markets.” This action follows Clinigen’s January 2023 sale of its kidney cancer treatment Proleukin (aldesleukin) to Iovance Biotherapeutics . This deal included an upfront payment of £166.7m ($211.8m), a milestone-based payment of £41.7m ($53m) upon first approval of lifileucel in advanced melanoma, and double-digit Proleukin global sales royalties from Iovance to Clinigen. Proleukin uses interleukin-2 to induce T cell-mediated tumour regression in advanced melanoma. CNX is developing lifileucel as a cell therapy for various cancers. The US Food and Drug Administration accepted a biologics licence application (BLA) for lifileucel in May 2023. In a press release , Clinigen CEO Jerome Charton said: “These medicines have been integral to Clinigen, but as we refocus our efforts, it is crucial to align our offerings with our core strategy and I’m delighted that CNX Therapeutics will be acquiring these brands.” Clinigen’s recent divestments follow others to strengthen its existing capabilities. Last year, the company acquired Drug Safety Navigator to improve its pharmacovigilance capabilities. It also expanded its US site due to reported growth in demand for its clinical supplies management services. This included the opening of new satellite sites in North Dakota and Pennsylvania. This year, Clinigen also sold its innovative contract development business Lamda Laboratories to Germany-based Adragos Pharma. Before this divestment, Lamda acted as Clinigen’s sole development centre. Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. 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Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address. Thank you. Please check your email to download the Report.

AcquisitionLicense out/in

10 Aug 2023

·www.biospace.com

Clinigen divests global rights to four cancer support therapies to CNX Therapeutics

Clinigendivests global rights to four cancer support therapies to CNX Therapeutics Clinigen Limited (‘Clinigen’), the global pharmaceutical services company, has completed the divestment of four cancer supportive care products from its established brands portfolio to CNX Therapeutics, a speciality pharmaceutical company with a focus on improving access to medicines that are critical to the well-being of patients. Under the terms of the agreement, (the financial terms for which are not being disclosed), Clinigen will divest four medicines; Cardioxane®, Savene®, Totect® and Ethyol®, all of which help mitigate the side effects patients may experience when treated with other cancer therapies. Cardioxane®, used in adults with advanced or metastatic breast cancer to prevent long-term harmful effects on the heart caused by treatment with certain anthracyclines. Savene®, used to treat anthracycline extravasation in adults, a rare condition that can impact cancer patients. Totect®, used for the treatment of anthracycline extravasation as well as for preventing cardiomyopathy associated with doxorubicin in women with metastatic breast cancer. Ethyol®, used to reduce the cumulative renal toxicity of cisplatin in patients with advanced ovarian cancer and for reduction of the toxic effects of radiation on normal oral tissues in patients with head and neck cancer. The divestment is the next step for Clinigen in its strategy of increasing focus on those areas of the pharmaceutical services market where it has a growing and sustainable competitive advantage, increasing its exposure to high value, niche services and divesting units and products which no longer support that goal. Earlier this year Clinigen agreed the sale of Proleukin® to Iovance Biotherapeutics, and later divested Lamda Laboratories SA, its European-based innovative contract development business, to Adragos Pharma GmbH. In late 2022, Clinigen acquired Drug Safety Navigator (‘DSN’), a specialist pharmacovigilance service provider based in the US, adding vital pharmacovigilance capabilities to its pharmaceutical services offering. Jerome Charton,Chief Executive Officer at Clinigen commented, “This divestment marks another milestone in Clinigen’s continued strategic evolution towards providing high-value services to the pharmaceutical and biotech sectors. These medicines have been integral to Clinigen, but as we refocus our efforts, it is crucial to align our offerings with our core strategy and I’m delighted that CNX Therapeutics will be acquiring these brands.” CNX Therapeutics’ CEO, Guy Clark said, “The addition of these products to the CNX portfolio strengthens our position as a provider of critically-important hospital injectable products, and demonstrates our commitment to improving the lives of patients by ensuring the supply of essential medicines. We recognise the great value of these products to prescribers and patients, and are very pleased to partner with Clinigen to transition this important portfolio of products and to ensure ongoing continuity of supply.” Greenhill & Co are acting as financial advisor to Clinigen. – Ends – Contact details: Consilium Strategic Communications Jessica Hodgson / Susan Stuart / Melissa Gardiner Tel: +44 (0) 20 3709 5700Clinigen@consilium-comms.com Notes to Editors About Clinigen Clinigen is a global, specialist pharmaceutical services company focused on providing ethical access to medicines. Its mission is to deliver the right medicine to the right patient at the right time. The Group supports pharmaceutical and biotech companies across the medical product lifecycle, from clinical through to commercial and operates from sites in North America, Europe, Africa and the Asia Pacific. Clinigen has more than 1,200 employees across five continents in 15 countries, and provides access in more than 120 countries every year. For more information on Clinigen, please visit: About CNX Therapeutics CNX Therapeutics is a speciality pharmaceutical company committed to improving the lives of patients by providing access to essential medicines. They commercialise and distribute a portfolio of pharmaceuticals for neurological, psychiatric and hospital emergencies in 40 countries worldwide, both directly and through strategic partnerships. CNX Therapeutics’ vision is to become a recognised partner of choice through their commercial excellence, patient focus and presence across Europe. They aim to have a pioneering and industry-leading approach to their Environment, Social and Governance (ESG) goals, which forms a key element of the organisation’s mission and objectives. For more information on CNX Therapeutics, please visit:

AcquisitionRadiation Therapy

100 Deals associated with Dexrazoxane Hydrochloride

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KEGG	Wiki	ATC	Drug Bank
D07807	Dexrazoxane Hydrochloride	V03AF02	DB00380

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Extravasation of Diagnostic and Therapeutic Materials	NO	CNX Therapeutics Ltd.	27 Jul 2006
Extravasation of Diagnostic and Therapeutic Materials	EU	CNX Therapeutics Ltd.	27 Jul 2006
Extravasation of Diagnostic and Therapeutic Materials	LI	CNX Therapeutics Ltd.	27 Jul 2006
Extravasation of Diagnostic and Therapeutic Materials	IS	CNX Therapeutics Ltd.	27 Jul 2006
Cytoprotective Agent	CN	Nanjing Hairun Pharmaceutical Co Ltd.	29 May 2006

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Extravasation of Diagnostic and Therapeutic Materials	Discovery	US	Clinigen Ltd.	06 Sep 2007
Hemorrhage	Discovery	IT	Valerio Therapeutics SA	01 Apr 2002
Hemorrhage	Discovery	PL	Valerio Therapeutics SA	01 Apr 2002
Hemorrhage	Discovery	NL	Valerio Therapeutics SA	01 Apr 2002
Hemorrhage	Discovery	DK	Valerio Therapeutics SA	01 Apr 2002
Hemorrhage	Discovery	DE	Valerio Therapeutics SA	01 Apr 2002
Bronchitis	Discovery	DK	Valerio Therapeutics SA	01 Jun 2001

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASH2024	Not Applicable	Acute Myeloid Leukemia	-	Dexrazoxane	vwhcnapoui(nkvlzozgxa) = aivgrfchuq domxitdfkp (kuwdoqcmsb ) View more	-	07 Dec 2024
				Non-initiators of Dexrazoxane	vwhcnapoui(nkvlzozgxa) = ukqxnqfusz domxitdfkp (kuwdoqcmsb ) View more
ASCO2023	Not Applicable	Neoplasms	142	Anthracycline + Dexrazoxane	(xwsaxymzjm) = caooyxulcr pbtfayxhlm (ghlpxkfbuf )	Positive	31 May 2023
				Anthracycline only	(xwsaxymzjm) = fucxblluxs pbtfayxhlm (ghlpxkfbuf ) View more
NCT03786783 (ANBL17P1, CTgov)	Phase 2	High Risk Neuroblastoma \| Ganglioneuroblastoma	42	External Beam Radiation Therapy+Etoposide+Carboplatin+Doxorubicin+Isotretinoin+Sargramostim+Topotecan+Dexrazoxane+Dinutuximab+Cyclophosphamide+Melphalan+Cisplatin+Vincristine+Thiotepa	pehuezpvfd(ptqshurlez) = pezagigmog cszdckoygr (zxsojdnksu, iuanjhxjoj - kyijchqvzd) View more	-	14 Mar 2023
Pubmed	Not Applicable	-	195	Dexrazoxane	(znzthghjbn) = oakonovymi wwgdhpkooh (oxwybluubm )	-	20 Jan 2023
				Doxorubicin with Dexrazoxane	-
NCT00980460 (AHEP0731, CTgov)	Phase 3	Hepatoblastoma \| Liver Cancer	236	Therapeutic Conventional Surgery (Very Low-risk Group)	tcglikbpkp(nupgkaijzb) = iyxrvmqzuy suihywhdiq (bgsbfwlwbc, uwgjltusfs - auladaqyoe) View more	-	28 Dec 2021
				Therapeutic Conventional Surgery+Cisplatin+Vincristine Sulfate+Fluorouracil (Low-risk Group (Regimen T))	tcglikbpkp(nupgkaijzb) = agoyhsajhj suihywhdiq (bgsbfwlwbc, scxezbwoyu - homytvlcyu) View more
ESC2021	Not Applicable	acute leukemia	2,375	Dexrazoxane	jtgofqbbzl(fydijngupo): OR = 1.15 (95% CI, 0.57 - 2.31), P-Value = 0.7 View more	-	29 Jun 2021
				No drug or placebo
NCT01231906 (AEWS1031, CTgov)	Phase 3	Peripheral Primitive Neuroectodermal Tumors \| Ewing Sarcoma	642	Laboratory Biomarker Analysis+Dexrazoxane+Etoposide+Cyclophosphamide+Ifosfamide+doxorubicin hydrochloride+Vincristine Sulfate (Arm A (Combination Chemotherapy))	(ixemddcojs) = xdyysowsha vuibbqarbh (fvivcntjhk, epmkxmljhq - gsgbmaanqc) View more	-	04 May 2021
				Laboratory Biomarker Analysis+Dexrazoxane+Etoposide+Cyclophosphamide+Ifosfamide+doxorubicin hydrochloride+Topotecan Hydrochloride+Vincristine Sulfate (Arm B (Combination Chemotherapy, Topotecan Hydrochloride))	(ixemddcojs) = gndrfxbhty vuibbqarbh (fvivcntjhk, qdnbttrnpu - twmqgjgvli) View more
P9404, P9425, P9426, DFCI 95-01, P9754 (ASCO2020)	Not Applicable	Neoplasms	173	Dexrazoxane+Doxorubicin	(xipklrujvw) = nccjtcfhfq dioayolcyc (gtoxlccehz, 6.0 - 18.0) View more	Positive	25 May 2020
				Doxorubicin	(xipklrujvw) = hpxppbojix dioayolcyc (gtoxlccehz, 6.0 - 28.2) View more
NCT00038142 (CTgov)	Phase 2	Ewing Sarcoma	46	ImmTher+Dexrazoxane+cyclophosphamide+Doxorubicin+Vincristine (Arm A: VACdxr With ImmTher)	isbsjzcnyl(ficpsufaqa) = codwhjqbwg dxvycpjduh (quozcttvro, yfsflvppme - lfovaiunzv) View more	-	29 Jan 2020
				Dexrazoxane+cyclophosphamide+Doxorubicin+Vincristine (Arm B: VACdxr)	isbsjzcnyl(ficpsufaqa) = vhynsudaab dxvycpjduh (quozcttvro, hmsehycstt - uvpoabigtu) View more
NCT00928200 (CTgov)	Phase 1	Food Hypersensitivity \| Recurrent Adult Acute Lymphoblastic Leukemia \| refractory acute lymphoid leukemia in relapse	1	Dexrazoxane+doxorubicin+Hydrocortisone+Erwinase+dexamethasone+Methotrexate+Vincristine+Cytarabine	oyszgfyvyr(tmtfgvnjpn) = dsanorpzfw kaqueydyfv (ivymhnpekt, hfpblfsdyc - cqqczdaboj) View more	-	19 Feb 2019

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