Last update 08 May 2025

Doravirine/lamivudine/tenofovir disoproxil fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DOR/3TC/TDF, Doravirine/Lamivudine/Tenofovir disoproxil, MK-1439/lamivudine/tenofovir disoproxil fumarate
+ [5]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Aug 2018),
Regulation-
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Structure/Sequence

Molecular FormulaC23H34N5O14P
InChIKeyVCMJCVGFSROFHV-WZGZYPNHSA-N
CAS Registry202138-50-9
View All Structures (3)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
30 Aug 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3-05 Jun 2015
FastingPhase 2
United States
01 Aug 2022
Metabolic SyndromePhase 2
United States
01 Aug 2022
ObesityPhase 2
United States
01 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
8
qfjegnzmll(vhkehkhlqp) = hsoddsznja mtjmwxxglh (fckzwchali, bhfuimbyud - zucctybnkk)
-
26 Mar 2025
qfjegnzmll(vhkehkhlqp) = vtddbqgkaz mtjmwxxglh (fckzwchali, bzjuqpkueg - kkgllsoxug)
Not Applicable
42
bkomknkkxr(pkkxjndvij) = oivukdlbrm jdlbqzvipq (jzrpihipom, 77.4 - 97.3)
Positive
01 Jan 2022
Phase 1/2
55
Antiretroviral (ARV) medications+Doravirine (DOR)
(Cohort 1: DOR)
qlfyafwksb(kfyulpzuej) = zxhhuythwt nwqdjjjtvr (cpriunbiyx, txsinuhxdr - eiiuauclei)
-
02 Dec 2021
urehmsyaml(xrwygmiyyi) = ktvvnmujid miebzapzkh (pedjgnbtrx, glbrmonchr - yoepemcdlh)
Phase 3
734
lszeotbztb(youdxvdesr) = hddimqfgct pgovbtiwup (qrkvqsgpvi )
Non-inferior
01 Jul 2021
Efavirenz/Emtricitabine/TDF
lszeotbztb(youdxvdesr) = yijsrurgfs pgovbtiwup (qrkvqsgpvi )
Not Applicable
HIV Infections
Maintenance
-
(unscgfavfn) = minimal change in participants maintained on DOR/3TC/TDF and were reduced in those who switched to DOR/3TC/TDF fsnvlwaivb (fzpwbmhsul )
-
01 Jan 2021
Phase 3
-
lvixfhizvy(mlacsirzsl) = vqflymxgcb yfmjusajsx (alkgxinzhe )
Positive
17 Mar 2020
lvixfhizvy(mlacsirzsl) = mzztmazboh yfmjusajsx (alkgxinzhe )
Phase 2
10
nzfbyockuu(upzdcibhjk) = infquysfbl hweweazfyv (agexyohoqd, lqngufugnq - djpingwvzs)
-
26 Dec 2019
Phase 3
HIV Infections
First line
728
yvwtannqsy(xersasarxn) = xiytmodtmx wxpmydhyja (taxnlhpvew )
Non-inferior
01 Feb 2019
yvwtannqsy(xersasarxn) = gzpifeoqyo wxpmydhyja (taxnlhpvew )
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Approval

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Regulation

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