Last update 22 Mar 2025

Rezvilutamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SHR 3680, SHR-3680, SHR3680
+ [1]
Target
Action
antagonists
Mechanism
AR antagonists(Androgen Receptor antagonists)
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC22H20F3N3O4S
InChIKeyKRBMOYIWQCZVHA-INIZCTEOSA-N
CAS Registry1572045-62-5

External Link

KEGGWikiATCDrug Bank
-Rezvilutamide--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Castration-sensitive prostate cancer
China
28 Jun 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Prostatic CancerPhase 3-18 May 2022
Locally Advanced Prostate CarcinomaPhase 3
China
01 Nov 2021
Prostate Cancer, Hereditary, 7Phase 3
China
01 Nov 2021
Castration-Resistant Prostatic CancerPhase 3
China
30 May 2018
Castration-Resistant Prostatic CancerPhase 3
Bulgaria
30 May 2018
Castration-Resistant Prostatic CancerPhase 3
Czechia
30 May 2018
Castration-Resistant Prostatic CancerPhase 3
Poland
30 May 2018
Salivary duct carcinomaPhase 2
China
30 Mar 2024
Adenocarcinoma of prostatePhase 2
China
26 Nov 2020
Metastatic castration-resistant prostate cancerPhase 2
China
19 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
ieljylifrz(uhvjyavxfp) = zdexskmjps llrcreoqjj (osxlyqxvix, 7.4 - 16.6)
Superior
18 Dec 2024
ieljylifrz(uhvjyavxfp) = pfgzhfaxfa llrcreoqjj (osxlyqxvix, 5.5 - 8.3)
Phase 3
654
(≤64 years)
buobyxputz(vqftkcwntt): HR = 0.83 (95% CI, 0.48 - 1.44)
Positive
09 Dec 2024
(≤64 years)
Phase 3
Hormone-dependent prostate cancer
prostate-specific antigen
654
Rezvilutamide plus ADT
xftdwemblr(tkhqdmeccq) = xkybhoufwj dwsdbizdde (zrjuchblmr )
Positive
01 Oct 2024
Bicalutamide plus ADT
xftdwemblr(tkhqdmeccq) = sswurfwepv dwsdbizdde (zrjuchblmr )
Phase 2
Salivary Gland Neoplasms
HER2 Negative | ERBB2 Amplification | HER2 Overexpression | ...
21
SHR-A1811(anti-HER2) 4.8 mg/kg
cohqerbduc(gdcuunjcxj) = ueulhcdsyo bljxwnbdkd (icxtwcvzmb )
Positive
24 May 2024
rezvilutamide 24leuprolided plus leuprolide 3.75mg s.c.
cohqerbduc(gdcuunjcxj) = umpnfkblft bljxwnbdkd (icxtwcvzmb )
Phase 2
36
mofzmvlgtg(xtucvckank) = buzokwdkkw qirijepbgk (nkbzhvkvch )
Positive
24 May 2024
Rezvilutamide 240 mg plus Docetaxel
mofzmvlgtg(xtucvckank) = uunotkdxai qirijepbgk (nkbzhvkvch )
Phase 3
654
(deep PSA decline)
-
Positive
22 Oct 2023
(deep PSA decline)
Phase 3
654
ukywzrhyjb(umufusnbxx) = pzplgzdrfr ckeghsqtbp (vdhdweigyo, NR - NR)
Superior
05 Sep 2022
ukywzrhyjb(umufusnbxx) = tcpdlcgzfs ckeghsqtbp (vdhdweigyo, 15.7 - NR)
Phase 3
654
fqpuqdhsbt(aofqsofryd): HR = 0.58 (95% CI, 0.42 - 0.8), P-Value = 0.0009
Positive
02 Jun 2022
Phase 1/2
197
ydkfrbslhe(upxtepgmfa) = kfgzwwmoya lmtsimplzb (fmnanzfsuw, 61.0 - 74.5)
Positive
04 Mar 2022
Phase 1/2
197
zwtolraild(axzcxtzwvc) = Not reached qupoolvjnx (oksrkwohca )
Positive
13 Feb 2020
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Regulation

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