Drug Type Small molecule drug |
Synonyms SHR 3680, SHR-3680, SHR3680 + [1] |
Target |
Action antagonists |
Mechanism AR antagonists(Androgen Receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date China (28 Jun 2022), |
RegulationPriority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China) |
Molecular FormulaC22H20F3N3O4S |
InChIKeyKRBMOYIWQCZVHA-INIZCTEOSA-N |
CAS Registry1572045-62-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Rezvilutamide | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Castration-sensitive prostate cancer | China | 28 Jun 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Prostatic Cancer | Phase 3 | - | 18 May 2022 | |
Locally Advanced Prostate Carcinoma | Phase 3 | China | 01 Nov 2021 | |
Prostate Cancer, Hereditary, 7 | Phase 3 | China | 01 Nov 2021 | |
Castration-Resistant Prostatic Cancer | Phase 3 | China | 30 May 2018 | |
Castration-Resistant Prostatic Cancer | Phase 3 | Bulgaria | 30 May 2018 | |
Castration-Resistant Prostatic Cancer | Phase 3 | Czechia | 30 May 2018 | |
Castration-Resistant Prostatic Cancer | Phase 3 | Poland | 30 May 2018 | |
Salivary duct carcinoma | Phase 2 | China | 30 Mar 2024 | |
Adenocarcinoma of prostate | Phase 2 | China | 26 Nov 2020 | |
Metastatic castration-resistant prostate cancer | Phase 2 | China | 19 Mar 2019 |
Phase 3 | - | rezvilutamide + ADT | ieljylifrz(uhvjyavxfp) = zdexskmjps llrcreoqjj (osxlyqxvix, 7.4 - 16.6) View more | Superior | 18 Dec 2024 | ||
bicalutamide + ADT | ieljylifrz(uhvjyavxfp) = pfgzhfaxfa llrcreoqjj (osxlyqxvix, 5.5 - 8.3) View more | ||||||
Phase 3 | 654 | Rezvilutamide + ADT (≤64 years) | buobyxputz(vqftkcwntt): HR = 0.83 (95% CI, 0.48 - 1.44) View more | Positive | 09 Dec 2024 | ||
Bicalutamide + ADT (≤64 years) | |||||||
Phase 3 | Hormone-dependent prostate cancer prostate-specific antigen | 654 | Rezvilutamide plus ADT | xftdwemblr(tkhqdmeccq) = xkybhoufwj dwsdbizdde (zrjuchblmr ) View more | Positive | 01 Oct 2024 | |
Bicalutamide plus ADT | xftdwemblr(tkhqdmeccq) = sswurfwepv dwsdbizdde (zrjuchblmr ) View more | ||||||
NCT05924256 (ASCO2024) Manual | Phase 2 | 21 | SHR-A1811(anti-HER2) 4.8 mg/kg | cohqerbduc(gdcuunjcxj) = ueulhcdsyo bljxwnbdkd (icxtwcvzmb ) View more | Positive | 24 May 2024 | |
cohqerbduc(gdcuunjcxj) = umpnfkblft bljxwnbdkd (icxtwcvzmb ) View more | |||||||
Phase 2 | 36 | mofzmvlgtg(xtucvckank) = buzokwdkkw qirijepbgk (nkbzhvkvch ) View more | Positive | 24 May 2024 | |||
Rezvilutamide 240 mg plus Docetaxel | mofzmvlgtg(xtucvckank) = uunotkdxai qirijepbgk (nkbzhvkvch ) View more | ||||||
Phase 3 | 654 | Rezvilutamide + ADT (deep PSA decline) | - | Positive | 22 Oct 2023 | ||
Bicalutamide + ADT (deep PSA decline) | |||||||
Phase 3 | 654 | ADT+Rezvilutamide | ukywzrhyjb(umufusnbxx) = pzplgzdrfr ckeghsqtbp (vdhdweigyo, NR - NR) View more | Superior | 05 Sep 2022 | ||
ADT+Bicalutamide | ukywzrhyjb(umufusnbxx) = tcpdlcgzfs ckeghsqtbp (vdhdweigyo, 15.7 - NR) View more | ||||||
Phase 3 | 654 | fqpuqdhsbt(aofqsofryd): HR = 0.58 (95% CI, 0.42 - 0.8), P-Value = 0.0009 View more | Positive | 02 Jun 2022 | |||
NCT02691975 (Pubmed) Manual | Phase 1/2 | 197 | ydkfrbslhe(upxtepgmfa) = kfgzwwmoya lmtsimplzb (fmnanzfsuw, 61.0 - 74.5) View more | Positive | 04 Mar 2022 | ||
Phase 1/2 | 197 | zwtolraild(axzcxtzwvc) = Not reached qupoolvjnx (oksrkwohca ) View more | Positive | 13 Feb 2020 |