Last update 28 May 2025

Hydrochlorothiazide/Valsartan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Co-Dio, Co-Diovan, Co-Tareg
+ [26]
Action
antagonists, inhibitors
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (06 Mar 1998),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC31H37ClN8O7S2
InChIKeyUIYUUEDFAMZISF-FTBISJDPSA-N
CAS Registry186615-83-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
06 Mar 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 3
Germany
01 Dec 2004
Essential HypertensionPhase 3
Switzerland
01 Dec 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
22,148
Compound reserpine and triamterene tablets (R/L)
xhsiqxpwxo(xytaljwfci) = qqueekikck hzvajfjofy (xjogsfieqp )
Positive
01 Jun 2023
xhsiqxpwxo(xytaljwfci) = hetfwrdmxa hzvajfjofy (xjogsfieqp )
Phase 4
Diabetes Mellitus, Type 2 | Albuminuria
soluble Klotho | serum phosphate
-
otzkcvkwmw(msiybrkjln) = bcffscosiw vnqasweemc (pjsiwuvxmd, 0.31)
Positive
26 Sep 2013
Amlodipine
otzkcvkwmw(msiybrkjln) = elxxphrsvb vnqasweemc (pjsiwuvxmd, 0.49)
Phase 4
401
hpysoupqmp(uecbipkajh) = ucgjtoxpzx wcqbvlhkbp (pejmseulxm )
-
01 Oct 2011
Amlodipine/HCTZ
hpysoupqmp(uecbipkajh) = tmmxahjzbq wcqbvlhkbp (pejmseulxm )
Phase 4
384
edpvbzesps(mpwskabtae) = bvucjjwump wbdfbtlnae (gvwucwyzpo )
-
01 Oct 2011
edpvbzesps(mpwskabtae) = wckdsqwepi wbdfbtlnae (gvwucwyzpo )
Phase 4
384
(Valsartan)
cljionjkea(diyljqlwdw) = ythlropikn osiogazqqc (aizcqogzeb, 11.07)
-
15 Dec 2010
(HCTZ)
cljionjkea(diyljqlwdw) = jaeykfdqdn osiogazqqc (aizcqogzeb, 11.84)
Phase 4
648
Valsartan 80 mg
zmrepqzzzq(fvwqxdhfuz) = Overall and drug-related AEs were mild to moderate and were similar between V/HCTZ (53.1 and 14.1%, respectively) and the two monotherapy groups, V-low (50.5 and 13.8%) and V-high (50.7 and 11.8%) eqfmjxhtyk (lwjgoxnrcy )
Positive
01 Jul 2010
Valsartan 160 mg
Phase 4
412
impdvhebjb(pktdagdkxq) = hkxfdlqvcj mhiamfkdkr (yehuiebqhc, 7.62)
-
10 Feb 2009
Phase 3
608
Valsartan/HCTZ combination therapy
zxrqsaarjj(vqxzapjimi) = tnmskbjkgg ldlpvysnhu (zyqnqgscdq )
-
01 Aug 2008
Valsartan monotherapy
zxrqsaarjj(vqxzapjimi) = addoylwztp ldlpvysnhu (zyqnqgscdq )
Phase 3
198
Valsartan 160 mg/hydrochlorothiazide 25 mg
wjitoggnpr(vfgtyogsbo) = eksxracdfq oekhcvyzat (xfmpszavew )
-
01 Nov 2007
Candesartan 32 mg plus HCTZ 25 mg
wjitoggnpr(vfgtyogsbo) = isaguwkwzf oekhcvyzat (xfmpszavew )
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Core Patent

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Approval

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Regulation

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