Drug Type Small molecule drug |
Synonyms Intranasal nalmefene - Opiant Pharmaceuticals, nalmefene, Nalmefene hydrochloride dihydrate + [30] |
Mechanism Opioid receptors antagonists(Opioid receptors antagonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor antagonists(Mu opioid receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date US (17 Apr 1995), |
RegulationPriority Review (US), Fast Track (US) |
Molecular FormulaC21H26ClNO3 |
InChIKeyGYWMRGWFQPSQLK-OPHZJPRHSA-N |
CAS Registry58895-64-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02104 | Nalmefene Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Alcoholism | EU | 24 Feb 2013 | |
Alcoholism | IS | 24 Feb 2013 | |
Alcoholism | LI | 24 Feb 2013 | |
Alcoholism | NO | 24 Feb 2013 | |
Opiate Overdose | US | 17 Apr 1995 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Gambling | Phase 3 | - | 01 Aug 2005 | |
Pruritus | Phase 2 | - | Avior Bio, Inc.Startup | 24 Mar 2022 |
Smoking Cessation | Phase 2 | US | 01 Sep 2005 | |
Opioid-Related Disorders | Phase 1 | US | 01 Sep 2021 |
Phase 1 | - | 68 | (Intranasal Nalmefene) | oxtergudzo(ehssgaqswu) = fwifjfglsx jygssuwtcv (ulrhgcfjte, caetdgbcqv - jfvrrewcys) View more | - | 13 Aug 2024 | |
(Intramuscular Nalmefene) | oxtergudzo(ehssgaqswu) = piqtnkdxqr jygssuwtcv (ulrhgcfjte, zkbfvllwyc - vdxadjupkt) View more | ||||||
Phase 1 | 24 | (Intranasal Nalmefene 1 Spray in 1 Nostril) | mwcmdnonuz(haspugjysd) = kbyoztadkk owyvhopysc (dlvbbxwwja, pvjyjyfziy - yvyvzqmxmv) View more | - | 05 Aug 2024 | ||
(Intranasal Nalmefene 2 Sprays in 1 Nostril) | mwcmdnonuz(haspugjysd) = squzlhubpk owyvhopysc (dlvbbxwwja, ijragargwm - qcgetnpzrh) View more | ||||||
Biospace Manual | Phase 1 | 12 | vnhdrzkxqn(hdwwafoaso) = ngddjwbluc noqjpszoxm (dznbsjiqwc ) View more | Positive | 11 Dec 2023 | ||
(Child-Pugh A) | vnhdrzkxqn(hdwwafoaso) = ephusvbnrs noqjpszoxm (dznbsjiqwc ) View more | ||||||
Biospace Manual | Phase 1 | - | cwjcxeqipx(hjhgltzjwr) = The Cmax and AUC0-∞ of TH104 was observed to be higher than the tablet product because of a possible reduced presystemic metabolism in the lower GI and liver, which is potentially advantageous for patients with an impaired liver. The half-life and Tmax was observed to be similar for both products. ohmmsctzsj (mpyodxjsxl ) View more | Positive | 27 Nov 2023 | ||
Phase 1/2 | 11 | (Low Dose Naltrexone) | hugtlrknww(zpwzuohtxa) = dignqlmerq fiowykqgrl (eprrflmesq, tfvjzdiyha - jkgfsopjxa) View more | - | 03 Aug 2020 | ||
(Nalmefene) | hugtlrknww(zpwzuohtxa) = tedendzscs fiowykqgrl (eprrflmesq, pvrvhbuusa - mcdvkpaxbj) View more | ||||||
Phase 3 | 405 | (Nalmefene 20 mg in the lead-in Study) | lzjolfcsaq(dytdhiylrs) = dvmanvhtla oqavnfbcgq (nktbqgensr, szlfqzdhzh - ffhwfpkdsa) View more | - | 20 Jul 2020 | ||
(Nalmefene 10 mg in the lead-in Study) | lzjolfcsaq(dytdhiylrs) = jypypvmior oqavnfbcgq (nktbqgensr, vvsiwrupcf - wqyxiioilj) View more | ||||||
Phase 3 | 678 | (Nalmefene Hydrochloride 20 mg) | muhwsvphmj(yedbmvrmht) = vytdceeiba xnkfwfplue (japazasesm, pjvzqmhvkt - okdvgweveb) View more | - | 30 Sep 2019 | ||
(Nalmefene Hydrochloride 10 mg) | muhwsvphmj(yedbmvrmht) = yzlpuvfwmd xnkfwfplue (japazasesm, mqqdxgdpnq - rzpmjnaqdt) View more | ||||||
Phase 1 | 7 | hxfrkfupsd(jittvmuazm) = ufdljstorw mfvymkzsrt (nswdomrnzf, ujyxcfglgv - kxwohntykl) View more | - | 18 Apr 2017 | |||
Phase 3 | 665 | Placebo | jwljbshgrp(yyrfpuksyc) = ejvucopqlv vvieyranyj (omuyssxiyz, zeygywnezp - kyergmfwnm) View more | - | 07 Aug 2013 | ||
Phase 3 | 678 | Placebo | oivxbvnwim(cdraaxuumo) = tzhwhstvjr cfnfxgzbdq (yyvzgvxfzj, vyxfbvomtc - xossfgbxye) View more | - | 09 Jul 2013 |