the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery: a Randomized, Double-blind, Positive-drug Parallel-controlled, Multi-center Clinical Study

The goal of this clinical trial is to learn if Oliceridine fumarate injection works to treat acute pain after abdominal surgery. It will also learn about the safety of Oliceridine fumarate injection. The main questions it aims to answer are:
1. Does Oliceridine fumarate injection works to treat acute pain after abdominal surgery?
2. Does Oliceridine fumarate injection lead to less adverse effect?
Researchers will compare Oliceridine fumarate injection to a positive-drug (Sufentanil Citrate) to see if Oliceridine fumarate injection not inferior to sufentanil in the efficacy and safety for acute pain after abdominal surgery.
Participants will:
1. Receive patient controlled analgesia treat using Oliceridine or sufentanil after surgery
2. Be followed up every 6 hours until 48 hours after surgery or before discharge

Start Date01 Aug 2024

Sponsor / Collaborator

Xiangya Hospital Central South University

NCT05957653 / Not yet recruitingPhase 4IIT

Lidocaine Combined With Sufentanil for Preventing Catheter-related Bladder Discomfort After Robot-assisted Radical Prostatectomy: a Randomized, Double-blind, Controlled Trial

The goal of this clinical trial is to evaluate the incidence and severity of postoperative catheter-related bladder discomfort after robot-assisted radical prostatectomy.
The main question it aims to answer is to evaluate incidence of CRBD immediately after extubation in resuscitation.
A total of 20ml of 2% lidocaine and 1μg/ml sufentanil or 20ml normal saline was injected into the bladder of the participants through the catheter. After drug injection, the catheter was clamped for 20 minutes, and then 100ml normal saline was injected into the bladder through the catheter to flush out.
Then, the incidence of CRBD was compared between the two groups.

Start Date07 Oct 2023

Sponsor / Collaborator

Shanghai Renji Hospital

NCT05384665 / TerminatedNot Applicable

Impact of Opioids on Heart Rate During Rapid Sequence Intubation: Double-blind Randomized Controlled Study

The patient is seen upstream by an anaesthetists resuscitator (MAR) in order to carry out his anesthesia consultation. If the patient meets the eligibility criteria he will be informed of the study and his signed consent will be obtained.
Patients will be divided into 3 parallel groups :
Group A (placebo +remifentanil)
Group B (sufentanil + placebo)
Group C (placebo + placebo)
Constants are taken at T0. A non-invasive continuous monitoring (Clearsight ©) will be used to collect data: blood pressure, heart rate, cardiac output.
To ensure double-blinding the nurse who prepares the syringes is not part of the anesthesia team. He/she numbers them in syringe n°1 and n°2 to indicate the order of injection to the MAR.
The MAR injects the drugs according to the standardized study plan (see below):
T1: the patient receives an intravenous bolus (IV) over 5 seconds of molecule n°1
3 minute delay
Patient receives Etomidate 0.3 mg/kg IV over 10 seconds
5 second delay
The patient receives an IV bolus over 30 seconds of molecule n°2
5 second delay
The patient receives Succinylcholine or Rocuronium IV over 5 seconds
T2: End of induction, oro-tracheal intubation (= T2)
The laryngoscopy is performed by an experienced MAR or nurse (IADE). The end of the intubation is defined by the fixation of the intubation tube (T3). Hemodynamic parameters are measured every minute for ten minutes after intubation (T4 to T13).
Maintenance of anesthesia is standardized with halogen gas (SEVOFLURANE) and an opioid (SUFENTANIL). Ten minutes after the patient's intubation (T13), the blind is lifted, allowing the addition of sufentanil in groups A and C before any surgical procedure.

Start Date16 May 2023

Sponsor / Collaborator

Centre Hospitalier Sud Francilien

100 Clinical Results associated with Sufentanil Citrate

100 Translational Medicine associated with Sufentanil Citrate

100 Patents (Medical) associated with Sufentanil Citrate

Literatures (Medical) associated with Sufentanil Citrate

10 Apr 2024·Videosurgery and Other Miniinvasive Techniques

Comparison of low and standard pneumoperitoneum pressure in laparoscopic pediatric inguinal hernia repair

Article

Author: Lyu, Yunxiao ; Chen, Liang

IntroductionThe effectiveness and safety of low pneumoperitoneum in laparoscopic pediatric inguinal hernia repair is unclear and required to explore.AimTo evaluate the benefits of low (LPP) vs. standard pneumoperitoneum pressure (SPP) in laparoscopic pediatric inguinal hernia repair.Material and methodsWe performed a retrospective cohort analysis of patients with pediatric inguinal hernia. The patients were divided into LPP and SPP groups. Anesthesia and postoperative characteristics were analyzed.ResultsWe enrolled 169 eligible patients in this study. Anesthesia and postanesthesia care unit times in the LPP group were lower than those in the SPP group (p = 0.00, p = 0.01, respectively). The LPP group had lower values for peak partial pressure of end-tidal carbon dioxide (P_ETCO₂; mm Hg) (33.37 ±4.09 vs. 36.56 ±4.08), trough P_ETCO₂ (38.33 ±5.04 vs. 40.46 ±4.14), and P_ETCO₂ at the end of surgery (35.29 ±4.59 vs. 38.76 ±4.22). The LPP group required less sufentanil citrate (8.76 ±4.07 ml vs. 18.03 ±16.04 ml) and midazolam (1.56 ±0.45 ml vs 1.79 ±0.59 ml) vs. the SPP group, respectively. There was no significant difference between the groups regarding postoperative complications.ConclusionsLPP was associated with shorter anesthesia and postanesthesia care unit times, and lower P_ETCO₂ values compared with SPP. Compared with the SPP group, the LPP group had comparable operation times and postoperative complications. However, long-term outcome studies are needed.

12 Jan 2024·Zhongguo zhen jiu = Chinese acupuncture & moxibustion

Effect of acupuncture at Shuitong and Shuijin points on sufentanil-induced cough in general anesthesia induction: a randomized controlled trial.

Article

Author: Ji, Jiafu ; Li, Peng ; Xu, Jiping ; Su, Fan ; Hu, Lihua

OBJECTIVESTo observe the therapeutic effect of acupuncture at Shuitong and Shuijin points on preventing sufentanil-induced cough and its influence on hemodynamics in general anesthesia induction.METHODSA total of 80 patients scheduled for elective surgery undergoing general anesthesia were randomly divided into an observation group (40 cases) and a control group (39 cases,1 case eliminated). In the control group, the routine anesthesia was performed,with intravenous injection of 1% sufentanil citrate 0.5 μg/kg, 1% propofol (total amount was calculated according to 2 mg/kg) and cisatracurium besilate 0.2 mg/kg. In the observation group, before routine anesthesia induction, acupuncture was applied to Shuitong and Shuijin points on the right and the needles were retained for 30 min. During anesthesia induction, the complications i.e. cough and chest wall stiffness were observed, and the systolic blood pressure (SBP), heart rate (HR) and pulse oxygen saturation (SpO₂) were monitored 5 min after the patients entered the operation room (T₀),at the moment of intravenous injection of sufentanil (T₁) and 2 min after sufentanil injection (T₂) , 1 min before and after endotracheal intubation (T₃,T₄) of the two groups, respectively.RESULTSDuring anesthesia induction,the condition of mild, moderate and severe cough in the observation group was superior to that of the control group (P<0.05), the total cases of cough and its total incidence were lower than those of the control group (P<0.05). Two cases of chest wall stiffness were present in each group, but without statistical difference between the two groups (P>0.05). In comparison of SBP, HR and SpO₂ at T₀, T₁, T₂, T₃ and T₄, the differences were not significant statistically between the two groups (P>0.05). SBP and HR increased at T₂ when compared with those at T₁ in the control group (P<0.05), but there was no statistical difference in SpO₂ (P>0.05); while, the differences in SBP, HR and SpO₂ were not significant at T₂ when compared with those at T₁ in the observation group (P>0.05).CONCLUSIONSAcupuncture at Shuitong and Shuijin points can effectively prevent from sufentanil-induced cough, reduce the severity of cough and stabilize the hemodynamic indicators.

01 May 2023·Applied Spectroscopy

Quantitative Raman Cross-Sections and Band Assignments for Fentanyl and Fentanyl Analogs

Article

Author: Wilcox, Phillip G ; Pardoe, Ian J ; Kline, Neal D ; Guicheteau, Jason A ; Emmons, Erik D

Raman cross sections and spectra were measured for five synthetic opioid fentanyl analogs: fentanyl citrate, sufentanil citrate, alfentanil HCl, carfentanil oxalate, and remifentanil HCl. The measurements were performed with excitation wavelengths in the visible (532 nm) and near infrared (785 nm). In addition, density functional theory (DFT) calculations were employed to generate simulated spectra of the compounds and aid in identification of the observed spectral modes. These cross-section measurements and calculations were also used to assess results from a series of measurements of fentanyls cut with other powdered materials. These measurements are valuable for assessment of field-deployable Raman chemical sensors for detection of fentanyl and fentanyl analogs, including when mixed with other materials.

News (Medical) associated with Sufentanil Citrate

08 Aug 2024

·www.echemi.com

Humanwell Healthcare Reports 3.86% Revenue Growth in H1 2024

The latest release shows that Humanwell Healthcare has delivered remarkable results in the first half of 2024, demonstrating excellent market performance. Specifically, the company managed to achieve solid growth in total operating revenue, totaling RMB12.861 billion, an increase of 3.86% over the same period last year, marking the fourth consecutive year of good growth for Humanwell Healthcare. Despite some fluctuations in net profit, Humanwell Healthcare's core subsidiary, Yichang Humanwell, maintained strong growth momentum and achieved double-digit growth rates, providing strong support for the company's overall performance. As a leading pharmaceutical company in China, Humanwell Healthcare has been committed to the research and development, production and sales of pharmaceutical products since its establishment in 1993. Headquartered in Wuhan, Hubei Province, Humanwell Healthcare is a key player in China's pharmaceutical industry. Humanwell Healthcare's product line is rich and diverse, including many star products. Compound Cloloterol propionate tablet, as one of the company's core products, is an oral drug for type 2 diabetes, which has the effect of significantly reducing blood sugar and protecting islet function, and enjoys a high reputation in the field of diabetes treatment in China. Gastrodine capsule is a Chinese medicine preparation for the treatment of ischemic stroke sequelae, which can significantly improve the blood supply to the brain and promote the repair of nerve function, and is an important representative of the company in the field of Chinese medicine. In addition, as the company's main product in the field of respiratory treatment, trimebutin tablets can effectively improve the respiratory function of patients with chronic obstructive pulmonary disease (COPD), and occupy an important position in the domestic COPD treatment market. Humanwell Healthcare continues to consolidate and expand its market leadership in the key area of neurological medicine. The company's two star narcotic products - remifentanil hydrochloride for injection and sufentanil citrate injection, the performance of the national hospital market in 2023 is particularly eye-catching. The combined sales of these two products reached 6.778 billion yuan, accounting for more than 40% of the market share. Among them, remifentanil hydrochloride for injection is as high as 90.28% of the market share, sitting firmly on the throne of "anesthesia first", its market position is rock-solid. Humanwell Healthcare will continue to uphold the philosophy of continuous innovation and excellence to further consolidate its leading position in the field of anesthetics. At the same time, the company will also accelerate the research and development process of new product pipelines, actively expand other therapeutic areas, and continuously improve its overall competitive strength with a diversified product portfolio and strong research and development strength. We firmly believe that with the joint efforts of all employees, Humanwell Healthcare will be able to create even more brilliant results and bring even greater returns to shareholders.

Drug Approval

20 Jun 2024

·www.globenewswire.com

XOMA Declares Quarterly Preferred Stock Dividends

EMERYVILLE, Calif., June 20, 2024 (GLOBE NEWSWIRE) -- XOMA Corporation (Nasdaq: XOMA) (“XOMA” or the “Company”) today announced its Board of Directors has authorized the following cash dividends to holders of XOMA’s Series A and Series B Cumulative Preferred Stock: Holders of the 8.625% Series A Cumulative Perpetual Preferred Stock (Nasdaq: XOMAP) shall receive a cash dividend equal to $0.53906 per share. Holders of depositary shares, each representing 1/1000 of a share of XOMA’s 8.375% Series B Cumulative Perpetual Preferred Stock (Nasdaq: XOMAO), shall receive a cash dividend equal to $0.52344 per depositary share. The preferred dividends will be paid on or about July 15, 2024, to respective holders of record at the close of business on July 3, 2024. About XOMA CorporationXOMA is a biotechnology royalty aggregator playing a distinctive role in helping biotech companies achieve their goal of improving human health. XOMA acquires the potential future economics associated with pre-commercial therapeutic candidates that have been licensed to pharmaceutical or biotechnology companies. When XOMA acquires the future economics, the seller receives non-dilutive, non-recourse funding they can use to advance their internal drug candidate(s) or for general corporate purposes. The Company has an extensive and growing portfolio of assets (asset defined as the right to receive potential future economics associated with the advancement of an underlying therapeutic candidate). For more information about the Company and its portfolio, please visit www.xoma.com or follow the Company on LinkedIn. Forward-Looking Statements/Explanatory NotesCertain statements contained in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify such forward-looking statements by terminology such as “will” or “shall”, the negative of these terms or similar expressions. These forward-looking statements are not a guarantee of XOMA’s performance, and you should not place undue reliance on such statements. These statements are based on assumptions that may not prove accurate, and actual results could differ materially from those anticipated due to certain risks inherent in the biotechnology industry, including those related to the fact that our product candidates subject to out-license agreements are still being developed, and our licensees may require substantial funds to continue development which may not be available; we do not know whether there will be, or will continue to be, a viable market for the products in which we have an ownership or royalty interest; and if the therapeutic product candidates to which we have a royalty interest do not receive regulatory approval, our third-party licensees will not be able to market them. Other potential risks to XOMA meeting these expectations are described in more detail in XOMA's most recent filing on Form 10-Q and in other SEC filings. Consider such risks carefully when considering XOMA's prospects. Any forward-looking statement in this press release represents XOMA's beliefs and assumptions only as of the date of this press release and should not be relied upon as representing its views as of any subsequent date. XOMA disclaims any obligation to update any forward-looking statement, except as required by applicable law. EXPLANATORY NOTE: Any references to “portfolio” in this press release refer strictly to milestone and/or royalty rights associated with a basket of drug products in development. Any references to “assets” in this press release refer strictly to milestone and/or royalty rights associated with individual drug products in development. As of the date of this press release, the commercial assets in XOMA’s milestone and royalty portfolio are VABYSMO® (faricimab-svoa), OJEMDA™ (tovorafenib), XACIATO™ (clindamycin phosphate) vaginal gel 2%, IXINITY® [coagulation factor IX (recombinant)], and DSUVIA® (sufentanil sublingual tablet). All other assets in the milestone and royalty portfolio are investigational compounds. Efficacy and safety have not been established. There is no guarantee that any of the investigational compounds will become commercially available. Investor contact:Juliane SnowdenXOMA+1-646-438-9754juliane.snowden@xoma.com Media contact:Kathy VincentKV Consulting & Management+1-310-403-8951kathy@kathyvincent.com

20 Jun 2024

·www.biospace.com

XOMA Declares Quarterly Preferred Stock Dividends - June 20, 2024

EMERYVILLE, Calif., June 20, 2024 (GLOBE NEWSWIRE) -- XOMA Corporation (Nasdaq: XOMA) (“XOMA” or the “Company”) today announced its Board of Directors has authorized the following cash dividends to holders of XOMA’s Series A and Series B Cumulative Preferred Stock: Holders of the 8.625% Series A Cumulative Perpetual Preferred Stock (Nasdaq: XOMAP) shall receive a cash dividend equal to $0.53906 per share. Holders of depositary shares, each representing 1/1000 of a share of XOMA’s 8.375% Series B Cumulative Perpetual Preferred Stock (Nasdaq: XOMAO), shall receive a cash dividend equal to $0.52344 per depositary share. The preferred dividends will be paid on or about July 15, 2024, to respective holders of record at the close of business on July 3, 2024. About XOMA Corporation XOMA is a biotechnology royalty aggregator playing a distinctive role in helping biotech companies achieve their goal of improving human health. XOMA acquires the potential future economics associated with pre-commercial therapeutic candidates that have been licensed to pharmaceutical or biotechnology companies. When XOMA acquires the future economics, the seller receives non-dilutive, non-recourse funding they can use to advance their internal drug candidate(s) or for general corporate purposes. The Company has an extensive and growing portfolio of assets (asset defined as the right to receive potential future economics associated with the advancement of an underlying therapeutic candidate). For more information about the Company and its portfolio, please visit or follow the Company on LinkedIn. Forward-Looking Statements/Explanatory Notes Certain statements contained in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify such forward-looking statements by terminology such as “will” or “shall”, the negative of these terms or similar expressions. These forward-looking statements are not a guarantee of XOMA’s performance, and you should not place undue reliance on such statements. These statements are based on assumptions that may not prove accurate, and actual results could differ materially from those anticipated due to certain risks inherent in the biotechnology industry, including those related to the fact that our product candidates subject to out-license agreements are still being developed, and our licensees may require substantial funds to continue development which may not be available; we do not know whether there will be, or will continue to be, a viable market for the products in which we have an ownership or royalty interest; and if the therapeutic product candidates to which we have a royalty interest do not receive regulatory approval, our third-party licensees will not be able to market them. Other potential risks to XOMA meeting these expectations are described in more detail in XOMA's most recent filing on Form 10-Q and in other SEC filings. Consider such risks carefully when considering XOMA's prospects. Any forward-looking statement in this press release represents XOMA's beliefs and assumptions only as of the date of this press release and should not be relied upon as representing its views as of any subsequent date. XOMA disclaims any obligation to update any forward-looking statement, except as required by applicable law. EXPLANATORY NOTE: Any references to “portfolio” in this press release refer strictly to milestone and/or royalty rights associated with a basket of drug products in development. Any references to “assets” in this press release refer strictly to milestone and/or royalty rights associated with individual drug products in development. As of the date of this press release, the commercial assets in XOMA’s milestone and royalty portfolio are VABYSMO® (faricimab-svoa), OJEMDA™ (tovorafenib), XACIATO™ (clindamycin phosphate) vaginal gel 2%, IXINITY® [coagulation factor IX (recombinant)], and DSUVIA® (sufentanil sublingual tablet). All other assets in the milestone and royalty portfolio are investigational compounds. Efficacy and safety have not been established. There is no guarantee that any of the investigational compounds will become commercially available. Investor contact: Juliane Snowden XOMA +1-646-438-9754 juliane.snowden@xoma.com Media contact: Kathy Vincent KV Consulting & Management +1-310-403-8951 kathy@kathyvincent.com

100 Deals associated with Sufentanil Citrate

External Link

KEGG	Wiki	ATC	Drug Bank
D00845	Sufentanil Citrate	N01AH03	DB00708

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Acute Pain	US	Vertical Pharmaceuticals LLC	02 Nov 2018
Pain	NO	Laboratoire Aguettant SAS	25 Jun 2018
Pain	LI	Laboratoire Aguettant SAS	25 Jun 2018
Pain	EU	Laboratoire Aguettant SAS	25 Jun 2018
Pain	IS	Laboratoire Aguettant SAS	25 Jun 2018
Anesthesia	US	Rising Pharmaceuticals, Inc.Startup	04 May 1984
Vaginal delivery procedure	US	Rising Pharmaceuticals, Inc.Startup	04 May 1984

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Chronic Pain	Phase 1	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	08 Mar 2023

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04959812 (CTgov)	Phase 1/2	Hemorrhage	46	sufentanil (Sufentanil)	fripgkdzdw(vfkzmavzhp) = xgcpdyfftw knbvcpiacc (lcvggggiqc, mensdznauy - wceuctwztu) View more	-	11 Jul 2024
				Placebo (Placebo)	fripgkdzdw(vfkzmavzhp) = pabbzxyruz knbvcpiacc (lcvggggiqc, pggsvdocmp - uwdfocrqmm) View more
NCT04561375 (CTgov)	Phase 4	-	61	Sufentanil (Intervention Group)	fjarabhvmu(wkzbgdfekv): Proportional odds ratio = 0.37 (95.0% CI, 0.13 - 1.07), P-Value = 0.067 View more	-	13 Dec 2023
				Fentanyl (Control Group)
NCT02989597 (MAPS, CTgov)	Phase 4	Pain, Postoperative	10	Spinal Fusion Surgery+Sufentanil+Methadone Hydrochloride+Dexamethasone+ketamine+Remifentanil (Intra-operative Methadone Hydrochloride)	jnyjjdttnc(lfnlcgsfhp) = zhthjtufye palrczqkib (ckebtiruyu, ovkxrgohzn - uwpxrjqgco) View more	-	25 Apr 2023
				Spinal Fusion Surgery+Sufentanil+Dexamethasone+ketamine+Remifentanil (Control)	jnyjjdttnc(lfnlcgsfhp) = weccwpjjlo palrczqkib (ckebtiruyu, mznfrzcwyy - kdomdehngn) View more
NCT04226495 (CTgov)	Phase 4	Anesthesia	64	Sufentanil Bolus (Sufentanil Bolus)	(czwrzhngwt) = zutbhklhck jqmbzxsfns (morgvgrdht, idxxlcbzxj - jtmnfdhlph) View more	-	28 Feb 2023
				Sufentanil Infusion (Sufentanil Infusion)	(czwrzhngwt) = nugmhpphbb jqmbzxsfns (morgvgrdht, puokobsbea - hnmnvccirv) View more
NCT02573597 (CTgov)	Phase 4	Pregnancy \| Duration of labor \| Labor Pain	31	sufentanil+Bupivacaine (Part A Group 1)	afnffftilh(xujafpiyli) = nlnizhiscj pmkftlebpd (mwcqxjseij, mzzotwwtlr - cjictkabrd) View more	-	18 Oct 2022
				sufentanil+Bupivacaine (Part A Group 2)	afnffftilh(xujafpiyli) = zqhvdffilw pmkftlebpd (mwcqxjseij, hwtbrtejwc - umuafemmgg) View more
NCT04177862 (CTgov)	Phase 4	Anesthesia \| Acute Pain	75	Sublingual Sufentanil (Sublingual Sufentanil)	vcoskhqsid(yzcmiaxawa) = gdywervyum tworlhexba (guhhwvdtyt, ffvguqoqei - luutpsptbm) View more	-	02 Feb 2021
				IV Fentanyl (IV Fentanyl)	vcoskhqsid(yzcmiaxawa) = yopxksmkdy tworlhexba (guhhwvdtyt, uzyevzwlbx - xpmjvmazpl) View more
NCT02662764 (CTgov)	Phase 3	Acute Pain	320	Zalviso™ 15 mcg	wdxkmihabv(jlzcsqsgsa) = ssrpfezuty hssyvirmnw (ddxcqkrlra, omvelwrtcv - azcaysfpyj) View more	-	08 Aug 2018
NCT01012999 (CTgov)	Phase 1/2	Pain \| Limb injury	16	sufentanil	ieiqawdvkv(jrizsfyzbp) = frwfnqsjpc wgsyaqgxqo (kibnqiobik, femyhpewgw - npwqhwxefv) View more	-	22 Jun 2017
NCT02430090 (CTgov)	Phase 2	Anesthesia	45	Levobupivacaine (Levobupivacaine)	zgwxnzggod(nfmzxkkeku) = nibjdefxsx zihuzdstar (grbpzcqcgn, mhalzzlfsb - idgmfqvrev) View more	-	10 Jun 2015
				Levobupivacaine+fentanyl (Levobupivacaine + Fentanyl)	zgwxnzggod(nfmzxkkeku) = xphcmhpzlg zihuzdstar (grbpzcqcgn, iiirpfhanz - xufkgivkxq) View more
NCT01539642 (Pubmed \| Reg Anesth Pain Med) Manual	Phase 3	Pain, Postoperative	-	Sufentanil Citrate	naeducxuvh(twvpxvrmad) = yaneioeznp cclbdxcrps (qhvwnfdaya )	Positive	01 Jan 2015
				Placebo	naeducxuvh(twvpxvrmad) = cpktayylao cclbdxcrps (qhvwnfdaya )

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