Drug Type Small molecule drug |
Synonyms 5-Fluorouracil ProTide, Fosifloxuridine nafalbenamide, FUDR-phosphoramidate + [2] |
Target |
Mechanism TYMS inhibitors(Thymidylate synthase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC29H29FN3O9P |
InChIKeyBIOWRMNRHMERIO-ZVAHOJSLSA-N |
CAS Registry1332837-31-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Adenocarcinoma of large intestine | Phase 2 | US | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | FR | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | DE | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | IT | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | ES | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | GB | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | US | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | FR | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | DE | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | IT | 18 Apr 2023 |
Phase 1 | - | gzlgvvhead(fkwdhihxgk) = pmfkemuivb tvqwbwyosv (tlcriimxgv ) View more | Positive | 02 Apr 2024 | |||
Phase 1/2 | Colorectal Cancer Second line | 46 | rovywqsosn(minrqevkdf) = Data presented also indicate that NUFOX and NUFIRI have favorable safety profiles when compared to historical data for the 5-FU-containing regimens FOLFOX and FOLFIRI, with lower rates of toxicities such as neutropenia and gastrointestinal disturbances that limit their clinical utility wrdejdhnrf (kmuhtdstsi ) | Positive | 12 Sep 2022 | ||
Phase 2 | 38 | NUFOX | tkvyfeobun(xmjxixtcob) = NUFOX: ALT elevation, nausea; 2 patients each (11%)
NUFIRI: ALT elevation; 2 patients (11%) qrkglwyrkk (nnsuljpcvx ) | - | 10 Sep 2022 | ||
NUFIRI | |||||||
Phase 1 | 38 | ivhaqygkyc(vdnkbtzzas) = ttvdfywklf iduwtsthjc (jcyakmzhrm ) | Positive | 16 Sep 2021 | |||
Phase 1 | 62 | NUC 3373 | bikgiiyqbl(evoilocsaf) = 2500mg/m2 D1,8,15 and 28, Q4 weekly sieezwtxhd (jkpqcrwovt ) View more | Positive | 16 Sep 2021 | ||
Phase 1/2 | 37 | abzljcfcbh(babwmtqczy) = vjudtltqmp slpdkfainr (hcswousnkw ) | - | 01 Jul 2021 | |||
Phase 1/2 | 36 | lzjohleyzg(ijnxjocrvm) = ofcgreuzmp brvancoaup (gcjrxaaxgv ) View more | - | 22 Jan 2021 |