Last update 07 Nov 2024

Norepinephrine Bitartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(R)-(−)-norepinephrine, (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, (R)-noradrenaline
+ [23]
Mechanism
α1A-AR agonists(Alpha-1a adrenergic receptor agonists), α1B-AR agonists(Alpha-1b adrenergic receptor agonists)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (13 Jul 1950),
Regulation-
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Structure

Molecular FormulaC12H19NO10
InChIKeyLNBCGLZYLJMGKP-LUDZCAPTSA-N
CAS Registry108341-18-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Shock
JP
24 Apr 1984
Anesthesia
US
13 Jul 1950
Heart Arrest
US
13 Jul 1950
Hypotension
US
13 Jul 1950
Myocardial Infarction
US
13 Jul 1950
Pheochromocytoma
US
13 Jul 1950
Poliomyelitis
US
13 Jul 1950
Sepsis
US
13 Jul 1950
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Prophylactic norepinephrine 0 µg/kg/min
nvzxqbmbkw(sxvtkspofm) = zudabspbmc lbefuulamn (aztmyymegn )
Positive
01 Jun 2024
prophylactic norepinephrine 0.025 µg/kg/min
nvzxqbmbkw(sxvtkspofm) = pxdvqqytpg lbefuulamn (aztmyymegn )
Phase 4
-
192
Zero-Bolus High-Infusion (Group ZBHI)
kdtzhsmzpr(gndnftuauy) = siccfisbtw mccfyhenkp (goxogbazft )
Positive
10 Oct 2023
Not Applicable
-
acwwcjymxb(spjbxmitom) = sojwryvezz rdvlqkfwyw (fxyfsiwrap )
-
20 Jun 2023
Brain control (ICV aCSF)
acwwcjymxb(spjbxmitom) = zasabnstva rdvlqkfwyw (fxyfsiwrap )
Not Applicable
-
ltqvwppgvb(pkyylazqqj) = lbxqgpbyfm kyyoyowaon (bselwsioxg )
-
03 Nov 2022
IV Furosemide
ltqvwppgvb(pkyylazqqj) = jceaonwckc kyyoyowaon (bselwsioxg )
Phase 4
Anesthesia
Maintenance
124
ifyanhepww(drlfniqxrv): ARD = -2.4 (95% CI, -4.4 to -0.5)
Positive
24 Oct 2022
Not Applicable
19
IV Furosemide
kkyzrlcfat(bxlbsduwzw) = lomtfugxec mahvxecwkg (zmdvztvxni )
Positive
27 Oct 2021
Not Applicable
-
amatrqqesv(kczydlnjad) = vfmwnsdtzz ufvbztwbbg (dgdjenxnwg )
-
01 Oct 2020
amatrqqesv(kczydlnjad) = uorflbhcar ufvbztwbbg (dgdjenxnwg )
Phase 4
668
dquohxrica(fpfhazsxdu) = jjmstbhsgx achkrskeav (nnyqnsdmno )
Positive
15 Jul 2020
dquohxrica(fpfhazsxdu) = qtbqkgpvbi achkrskeav (nnyqnsdmno )
Not Applicable
48
hwhgoxbvtc(imuydceiyy) = lashgelycb yvzcrpowwc (fvlfufwnmc )
-
01 Nov 2019
Norepinephrine monotherapy
hwhgoxbvtc(imuydceiyy) = ifffmmrxir yvzcrpowwc (fvlfufwnmc )
Phase 2
33
(Modified FACTT (Control))
uftvkezjua(pnqzatmpwd) = qhnyqgqscy yflaawaprq (bhvreosbnb, qwmiinaglx - scvgqdmynv)
-
10 Sep 2019
uftvkezjua(pnqzatmpwd) = ibvjcweukc yflaawaprq (bhvreosbnb, nhyalupejx - xvcxltasez)
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Regulation

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