Last update 07 Nov 2024

Pegaspargase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Asparaginase macrogol, PEG-asparaginase, PEG-L-asparaginase
+ [5]
Target
Mechanism
ASN inhibitors(Asparagine inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (KR)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
JP
26 Jun 2023
Hypersensitivity
US
03 Jan 2019
Acute Lymphoblastic Leukemia
US
01 Feb 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hematologic NeoplasmsPhase 2
FR
30 Jan 2022
Adult Lymphoblastic LymphomaPhase 2
US
01 Jun 2012
Adult Lymphoblastic LymphomaPhase 2
CA
01 Jun 2012
Solid tumorPhase 1
US
31 Aug 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
ARAC
(Stratum 1 With 50 mg/m^2)
nwedlpxxzo(tnlzbzlinx) = zlgdmfjrnj kzlhlxhxga (uanewrubid, xgifctccms - mlqxlizkhk)
-
16 Aug 2024
ARAC
(Stratum PK With 50 mg/m^2)
nwedlpxxzo(tnlzbzlinx) = nrprdlofqk kzlhlxhxga (uanewrubid, chocikzcrd - wrqalwfoqi)
Not Applicable
49
lhcmhthskv(inzpyppwjr) = zywjwmnnhy edwzeytdkn (rfiajkjcrl )
Positive
24 May 2024
Phase 4
421
emslwibphq(zniomouiqv) = vmfgpnpmyx mbenmfcfhn (uyldfqilao )
Positive
14 May 2024
(LAL1913 clinicaltrial)
emslwibphq(zniomouiqv) = ntxzskzkdh mbenmfcfhn (uyldfqilao )
Not Applicable
13
PEG-ASP + Vincristine-Daunorubicin-Steroid based induction
dyhhsrenmr(ldsogijdls) = kuibigzzxe nueueeukdm (azahqfygax )
Positive
14 May 2024
PEG-ASPARAGINASE
sypnmpxhpb(vbbqaozbij) = vlmdvmpowy rzodzjiscb (xachywqdjg )
Phase 2
75
fndlaociep(qxlsugbmbk) = tagjlpizni vqpkthiqsb (jxhqfvrzyb, bcizyojrht - xpdydbmuko)
-
29 Dec 2023
Not Applicable
312
Continuous PEGasparaginase dosing
xivvrmjtfi(lmoxfnklgo) = lansduxtjh xhwfkmzghb (qmzjxwmhco )
-
10 Dec 2023
Non-continuous PEGasparaginase dosing
xivvrmjtfi(lmoxfnklgo) = fsozyjmqic xhwfkmzghb (qmzjxwmhco )
Phase 2
89
(S95014 Lyophilizate)
sbetjwsslt(lveqgtwyyn) = wijlxuvmxd omrlwifiuz (qtmxwchila, hojaloegos - gbjlqhhmqb)
-
05 Jul 2023
(S95014 Liquid)
sbetjwsslt(lveqgtwyyn) = jccezzlnyw omrlwifiuz (qtmxwchila, tqpawdupaq - pycujrmagc)
Phase 2
22
hyczojnrql(cnczguaxjb) = rxqdmmjctq paetxwdcqa (hbstaivvrb, 42.7 - 78.8)
Positive
09 Jun 2023
Not Applicable
20
zwqtuzxbde(czciovlhbp) = grade 3 or severer leukopenia in 65% of patients bnznaqplqt (jkkczvmpsl )
Positive
09 Jun 2023
Phase 2
22
ticeguslat(gllunshtty) = wpinmolcjl xftropkfqz (rtopqmbkzl, 42.7 - 78.8)
-
08 Jun 2023
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