Last update 16 May 2025

Ditiazem Hydrochloride

Overview

Basic Info

SummaryDiltiazem,sold under the brand name Cardizem among others, is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Although precise mechanisms of its antianginal actions are still being delineated, CARDIZEM is believed to act in the following ways:CARDIZEM has been shown to be a potent dilator of coronary arteries both epicardial and subendocardial. Spontaneous and ergonovine-induced coronary artery spasms are inhibited by CARDIZEM. CARDIZEM has been shown to produce increases in exercise tolerance,probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal exercise workloads. CARDIZEM is indicated for the management of chronic stable angina and angina due to coronary artery spasm. Diltiazem was first launched in Japan by Takeda Mitsubishi in 1973, and later approved by Bausch Health US LLC in the United States in 1982.
Drug Type
Small molecule drug
Synonyms
Diltiazem hydrochloride (JP17/USP), Diltiazem Hyudrochloride, Diltizem Hydrochloride
+ [50]
Target
Action
blockers
Mechanism
Cav2.2 blockers(Voltage-gated N-type calcium channel alpha-1B subunit blockers)
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Structure/Sequence

Molecular FormulaC22H27ClN2O4S
InChIKeyHDRXZJPWHTXQRI-BHDTVMLSSA-N
CAS Registry33286-22-5

External Link

KEGGWikiATCDrug Bank
D00616-

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Paroxysmal supraventricular tachycardia
United States
21 Feb 2025
rapid ventricular response
United States
21 Feb 2025
Atrial Fibrillation
United States
28 Oct 2021
Atrial Flutter
United States
28 Oct 2021
Tachycardia, Paroxysmal
United States
28 Oct 2021
Tachycardia, Supraventricular
United States
28 Oct 2021
Angina, Stable
United States
05 Nov 1982
Angina Pectoris
Japan
08 Aug 1973
Hypertension
Japan
08 Aug 1973
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
5
(Beta Blocker (Nebivolol))
eyjlenefby(yqpdpuvwsr) = kukxsfkdym brwvusmsat (ydhsrvgwnz, 24.4)
-
25 Feb 2025
(Calcium Channel Blocker (Diltiazem))
eyjlenefby(yqpdpuvwsr) = jachhoghhm brwvusmsat (ydhsrvgwnz, NA)
FDA_CDER
ManualManual
Not Applicable
-
yhckexmckm(ivopcakjcp) = amxgryohib psctafnrbs (qpoahlipth )
Positive
21 Feb 2025
control
-
Not Applicable
252
Low dose (<0.1875 mg/kg)
epviiwyxyh(rbvrkbtzaa) = fhqdyzfydt wtynwkyroh (tymqfzukaj )
-
01 Mar 2023
Weight-based dose (0.1875 to 0.3125 mg/kg)
fwyxxuzqig(umgvbiazvi) = fgventwzwe iqmktxwtmf (kjurwyilyz )
Not Applicable
-
IV diltiazem monotherapy
wxdxemtfgj(gqopywimxu) = vklajwqvxs lshtjeywwt (pkqrfprhyn )
Negative
01 Feb 2023
IV diltiazem with calcium
wxdxemtfgj(gqopywimxu) = drrzjgxlfu lshtjeywwt (pkqrfprhyn )
Phase 3
126
wbvdytebpu(zrdccafytv) = zuzsdutlxt suithbzhsn (vhrlpteopb )
Negative
02 Apr 2022
Placebo
wbvdytebpu(zrdccafytv) = gsrpxlcrzn suithbzhsn (vhrlpteopb )
Not Applicable
-
aislgvfnpk(ggzrlmakkv) = mywuazumcp gplsrxbiyz (qujzorgfvm, 22)
Positive
01 Sep 2020
aislgvfnpk(ggzrlmakkv) = ogntqibobu gplsrxbiyz (qujzorgfvm, 15)
Phase 1
22
(Dofetilide + Mexiletine)
pqlkqrxovx(snmzxopppw) = gabqjvskwc ilqkgemvuf (kldxwusjvj, xpybbrgvmr - taloxqooec)
-
08 Jun 2016
(Dofetilide + Lidocaine)
pqlkqrxovx(snmzxopppw) = zcyatsafoj ilqkgemvuf (kldxwusjvj, btowhysigl - pimudpdnbs)
Not Applicable
-
azfqywsqwa(evknppvpld) = eljjfjdujl jkmvsxrwxu (tridgayell )
Positive
01 Aug 2015
Metoprolol
azfqywsqwa(evknppvpld) = mehknolrgx jkmvsxrwxu (tridgayell )
Phase 2/3
39
(I- Diltiazem)
tkiflwvxvv(rgmgcbdtvl) = pjxovadlos yqdzoepgre (benhatapcz, 0.27)
-
07 Apr 2015
Placebo
(II- Placebo)
tkiflwvxvv(rgmgcbdtvl) = tigwbimmmi yqdzoepgre (benhatapcz, 0.42)
Not Applicable
-
liigtwngma(iyerfiboew) = vtyqrrpibe ywijmjnavv (myftgmioao, 0.35 - 0.51)
Negative
05 Nov 2013
-
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