A Phase 1 and Pharmacokinetic Study of Uproleselan (GMI-1271, NSC #801708) in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome or Mixed Phenotype Acute Leukemia That Expresses E-selectin Ligand on the Cell Membrane and is in Second or Greater Relapse or That is Refractory to Relapse Therapy

This phase I trial tests the safety, side effects, and best dose of uproleselan in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia, myelodysplastic syndrome or mixed phenotype acute leukemia that has come back (relapsed) or does not respond to treatment (refractory) and that expresses E-selectin ligand on the cell membrane. Uproleselan binds to E-selectin expressed on endothelial cells of the bone marrow and prevents their interaction with selectin-E ligand-expressing cancer cells. This may prevent leukemia cells from being sequestered in the bone marrow niche and escaping the effect of chemotherapy. Chemotherapy drugs, such as fludarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving uproleselan in combination with fludarabine and cytarabine may enhance their activity.

Start Date10 Oct 2023

Sponsor / Collaborator

National Cancer Institute

[+1]

NCT05569512 / TerminatedPhase 1IIT

A Phase 1/2 Trial of Uproleselan Combined With High Dose Busulfan Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for Patients With Chemotherapy Resistant Acute Myeloid Leukemia

This research study is studying a new drug, uproleselan, to see if it is safe and effective in decreasing relapse after stem cell transplant and improving leukemia-free survival in pediatric patients with acute myeloid leukemia (AML).
The name of the study drugs involved in this study are:
* Uproleselan
* Busulfan
* Clofarabine
* Fludarabine
* Tacrolimus
* Methotrexate
* Mycophenolate Mofetil

Start Date06 Oct 2022

Sponsor / Collaborator

Dana-Farber Cancer Institute, Inc.

[+1]

NCT05057221 / TerminatedPhase 1/2IIT

A Pilot Study to Assess the Safety, Tolerability and Efficacy of Selectin Inhibitor Uproleselan (GMI-1271) in Patients With COVID-19 Pneumonia

The purpose of this study is to find out whether the drug uproleselan can help patients with severe COVID-19 pneumonia. Investigators will study both the side effects of the drug and assess if the drug will help patients recover more quickly and slow down the progression of acute respiratory failure.

Start Date12 Nov 2021

Sponsor / Collaborator

University of Michigan

[+1]

100 Clinical Results associated with Uproleselan

100 Translational Medicine associated with Uproleselan

100 Patents (Medical) associated with Uproleselan

Literatures (Medical) associated with Uproleselan

01 Jun 2024·British journal of haematology

Combining 5‐azacitidine with the E‐selectin antagonist uproleselan is an effective strategy to augment responses in myelodysplasia and acute myeloid leukaemia

Article

Author: Magnani, John L. ; Lincz, Lisa F. ; Enjeti, Anoop K. ; Bond, Danielle R. ; Smith, Theodore A. G. ; Fogler, William E.

Summary:

The interaction of acute myeloid leukaemic (AML) blasts with the bone marrow (BM) microenvironment is a major determinant governing disease progression and resistance to treatment. The constitutive expression of E‐selectin in the vascular compartment of BM, a key endothelial cell factor, directly mediates chemoresistance via E‐selectin ligand/receptors. Despite the success of hypomethylating agent (HMA)‐containing regimens to induce remissions in older AML patients, the development of primary or secondary resistance is common. We report that following treatment with 5‐azacitidine, promoter regions regulating the biosynthesis of the E‐selectin ligands, sialyl Lewis X, become further hypomethylated. The resultant upregulation of these gene products, in particular α(1,3)‐fucosyltransferase VII (FUT7) and α(2,3)‐sialyltransferase IV (ST3GAL4), likely causes functional E‐selectin binding. When combined with the E‐selectin antagonist uproleselan, the adhesion to E‐selectin is reversed and the survival of mice transplanted with AML cells is prolonged. Finally, we present clinical evidence showing that BM myeloid cells from higher risk MDS and AML patients have the potential to bind E‐selectin, and these cells are more abundant in 5‐azacitidine‐non‐responsive patients. The collective data provide a strong rationale to evaluate 5‐azacitidine in combination with the E‐selectin antagonist, uproleselan, in this patient population.

01 May 2024·Blood reviews

Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?

Review

Author: Magnani, John L ; Lazarus, Hillard M ; Uy, Geoffrey L ; Lozier, Jay N ; Becker, Pamela S ; Jonas, Brian A ; DeAngelo, Daniel J ; Winkler, Ingrid G ; Fisher, Dennis M

E-selectin, a cytoadhesive glycoprotein, is expressed on venular endothelial cells and mediates leukocyte localization to inflamed endothelium, the first step in inflammatory cell extravasation into tissue. Constitutive marrow endothelial E-selectin expression also supports bone marrow hematopoiesis via NF-κB-mediated signaling. Correspondingly, E-selectin interaction with E-selectin ligand (sialyl Lewis^x) on acute myeloid leukemia (AML) cells leads to chemotherapy resistance in vivo. Uproleselan (GMI-1271) is a carbohydrate analog of sialyl Lewis^x that blocks E-selectin binding. A Phase 2 trial of MEC chemotherapy combined with uproleselan for relapsed/refractory AML showed a median overall survival of 8.8 months and low (2%) rates of severe oral mucositis. Clinical trials seek to confirm activity in AML and mitigation of neutrophil-mediated adverse events (mucositis and diarrhea) after intensive chemotherapy. In this review we summarize E-selectin biology and the rationale for uproleselan in combination with other therapies for hematologic malignancies. We also describe uproleselan pharmacology and ongoing clinical trials.

01 Mar 2022·XenotransplantationQ3 · MEDICINE

Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood

Q3 · MEDICINE

Article

Author: Ayares, David ; Karavi, Kasinath ; Azimzadeh, Agnes ; Phelps, Carol ; Connolly, Margaret ; Burdorf, Lars ; Sorrells, Lori ; Pierson, Richard N. ; Habibabady, Zahra A. ; Eyestone, Will ; Pollok, Franziska ; Miura, Shuhei ; Pratts, Shannon ; Dandro, Amy

Abstract:

Background:

Loss of barrier function when GalTKO.hCD46 porcine lungs are perfused with human blood is associated with coagulation pathway dysregulation, innate immune system activation, and rapid sequestration of human formed blood elements. Here, we evaluate whether genetic expression of human tissue factor pathway inhibitor (hTFPI) and human CD47 (hCD47), alone or with combined selectin and integrin adhesion pathway inhibitors, delays GalTKO.hCD46 porcine lung injury or modulates neutrophil and platelet sequestration.

Methods:

In a well‐established paired ex vivo lung perfusion model, GalTKO.hCD46.hTFPI.hCD47 transgenic porcine lungs (hTFPI.hCD47, n = 7) were compared to GalTKO.hCD46 lungs (reference, n = 5). All lung donor pigs were treated with a thromboxane synthase inhibitor, anti‐histamine, and anti‐GPIb integrin‐blocking Fab, and were pre‐treated with Desmopressin. In both genotypes, one lung of each pair was additionally treated with PSGL‐1 and GMI‐1271 (P‐ and E‐selectin) and IB4 (CD11b/18 integrin) adhesion inhibitors (n = 6 hTFPI.hCD47, n = 3 reference).

Results:

All except for two reference lungs did not fail within 480 min when experiments were electively terminated. Selectin and integrin adhesion inhibitors moderately attenuated initial pulmonary vascular resistance (PVR) elevation in hTFPI.hCD47 lungs. Neutrophil sequestration was significantly delayed during the early time points following reperfusion and terminal platelet activation was attenuated in association with lungs expressing hTFPI.hCD47, but additional adhesion pathway inhibitors did not show further effects with either lung genotype.

Conclusion:

Expression of hTFPI.hCD47 on porcine lung may be useful as part of an integrated strategy to prevent neutrophil adhesion and platelet activation that are associated with xenograft injury. Additionally, targeting canonical selectin and integrin adhesion pathways reduced PVR elevation associated with hTFPI.hCD47 expression, but did not significantly attenuate neutrophil or platelet sequestration. We conclude that other adhesive mechanisms mediate the residual sequestration of human formed blood elements to pig endothelium that occurs even in the context of the multiple genetic modifications and drug treatments tested here.

News (Medical) associated with Uproleselan

06 Nov 2024

·www.businesswire.com

GlycoMimetics Announces New Uproleselan Clinical Data Will Be Presented at ASH Annual Meeting

ROCKVILLE, Md.--( BUSINESS WIRE )--GlycoMimetics, Inc. (Nasdaq: GLYC) today announced that data from multiple clinical trials studying uproleselan in patients with acute myeloid leukemia (AML) have been accepted for presentation at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition taking place in San Diego, California, on December 7-10, 2024. ASH Annual Meeting abstracts may be accessed online at www.hematology.org . Details of GlycoMimetics presentations are as follows (all times PT): Publication Number: 733 Type: Oral Title: Efficacy and Safety of Uproleselan Combined with Chemotherapy Vs. Chemotherapy Alone in Relapsed/Refractory Acute Myeloid Leukemia: Findings from an International Phase 3 Trial Presenter: Daniel DeAngelo, M.D., Ph.D. Session Name: 616. Acute Myeloid Leukemias: Investigational Drug and Cellular Therapies: New Treatment Approaches for AML Session Date/ Presentation Time: Monday, December 9, 2024, 10:30 AM – 12:00 PM Publication Number: 1503 Type: Poster Title: Updated Results of a Phase I Study of Uproleselan Combined with Azacitidine and Venetoclax for the Treatment of Older or Unfit Patients with Treatment Naive Acute Myeloid Leukemia Presenter: Brian Jonas, M.D., Ph.D. Session Name: 616. Acute Myeloid Leukemias: Investigational Drug and Cellular Therapies: Poster I Session Date/ Presentation Time: Saturday, December 7, 2024, 5:30 PM - 7:30 PM Publication Number: 4262 Type: Poster Title: Final Results of a Phase II Study of Uproleselan Combined with Cladribine and Low-Dose Cytarabine for Patients with Treated Secondary Acute Myeloid Leukemia (ts-AML) Presenter: Caitlin Rausch, PharmD. Session Name: 616. Acute Myeloid Leukemias: Investigational Drug and Cellular Therapies: Poster III Session Date/Presentation Time: Monday, December 9, 2024, 6:00 – 8:00 PM About GlycoMimetics, Inc. GlycoMimetics is a late clinical-stage biotechnology company discovering and developing glycobiology-based therapies for cancers, including AML, and for inflammatory diseases. The company’s scientific approach is based on an understanding of the role that carbohydrates play in cell recognition. Its specialized chemistry platform can be used to discover small molecule drugs, known as glycomimetics, that alter carbohydrate-mediated recognition in diverse disease states, including cancers and inflammation. The company’s goal is to develop transformative therapies for diseases with high unmet medical need. GlycoMimetics is headquartered in Rockville, MD in the BioHealth Capital Region. Learn more at www.glycomimetics.com . Forward-Looking Statements To the extent that statements contained herein are not descriptions of historical facts, they are forward-looking statements reflecting the current beliefs and expectations of the management of GlycoMimetics, Inc. (“GlycoMimetics,” “we,” “us,” or “our”). Forward-looking statements include, but are not limited to, the expected presentation of clinical data for uproleselan, and any other statement containing terminology such as “may,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “potential,” “intends,” or “continue,” or the negative of these terms or other comparable terminology. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry’s actual results, levels of activity, performance, or achievements to be materially different from those discussed, implied or otherwise anticipated by such statements. You are cautioned not to place undue reliance on such forward-looking statements, which are current only as of the date of this presentation. For a further description of the risks associated with forward-looking statements, as well as other risks facing GlycoMimetics, please see the risk factors described in the Company’s Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission on March 27, 2024 and the Company’s Quarterly Reports on Form 10-Q filed with the SEC on May 9, 2024 and August 8, 2024, as well as other reports we file with the U.S. Securities and Exchange Commission from time to time, including those factors discussed under the caption “Risk Factors” in such filings. Forward-looking statements speak only as of the date of this presentation, and GlycoMimetics undertakes no obligation to update or revise these statements, except as may be required by law.

Phase 2Phase 1ASHClinical ResultPhase 3

29 Oct 2024

·medcitynews.com

Going In Reverse Is Faster Way Forward for Crescent Bio’s Cancer Immunotherapy - MedCity News

It’s hard for preclinical biotech companies to go public these days as investors look for human data that can reduce investment risk. Crescent Biopharma is more than a year away from the clinic, but joining the public markets now enables the biotech to capitalize on a recent groundbreaking cancer drug development still fresh in investors’ minds. Crescent is going public in a reverse merger with GlycoMimetics, the companies announced Tuesday. When the transaction is complete, the merged entity will operate under the Crescent Biopharma name. It will be led by Jonathan Violin, Crescent’s current CEO, who is expected to become interim CEO of the combined company. Crescent will also be capitalized with $200 million from agreements with a select group of investors that have pledged to purchase the combined company’s securities. Those purchases will happen immediately after the merger closes in the second quarter of 2025. Crescent’s lead program is CR-001, a bispecific antibody in development for cancer. Most companies trying to build an investment case talk about how their drugs are differentiated from rivals. Crescent’s executives are doing the opposite, touting similarities to another drug: Summit Therapeutics’ ivonescimab. Last month, that drug posted data showing it topped the blockbuster Merck immunotherapy Keytruda in a head-to-head Phase 3 test. In patients with advanced cases of non-small cell lung cancer, treatment with ivonescimab led to a 49% reduction in the risk of disease progression or death compared to treatment with Keytruda, Summit said. Sponsored Post The Funding Model for Cancer Innovation is Broken — We Can Fix It Closing cancer health equity gaps require medical breakthroughs made possible by new funding approaches. By Eve McDavid - CEO of Mission-Driven Tech Keytruda is an antibody designed to block a particular checkpoint protein, which in turn enables immune cells to recognize and go after cancer cells. Ivonescimab, discovered by Summit’s China-based partner Akeso, is a bispecific antibody that blocks two targets: PD-1, the same receptor targeted by Keytruda, and the cancer-driving protein VEGF. Crescent’s CR-001 is also a bispecific antibody designed to block both of those targets. Speaking during a Tuesday conference call, Violin said his company’s drug replicates the properties of ivonescimab. Like Summit’s drug, Crescent’s bispecific antibody works by cooperative binding, meaning it is most active in the presence of both VEGF and PD-1. “This enables the molecule to deliver benefits to patients that are more than the sum of its parts, and to do so safely,” Violin said. “This novel format enables VEGF to create ‘daisy chains’ of drug molecule, linking them together and increasing the potency for PD-1 blockade. This unique design also may enable localization of drug to the tumor microenvironment, which may help reduce systemic toxicity.” CR-001 is undergoing the preclinical research that could support an investigational new drug application, which is expected in the fourth quarter of next year or early 2026. Assuming the application is cleared, preliminary clinical data could come in the second half of 2026, Violin said. Because CR-001 replicates the properties of Summit’s drug, Crescent believes data from a few dozen patients can “connect the dots” back to data from hundreds of ivonescimab-treated patients. “We know the ivonescimab data has catalyzed massive interest in advancing next-generation checkpoint inhibitor therapy — the PD1/PDL1 class is currently a $50 billion market and growing, so when something beats the leader of such a large and important drug class, we expect competition,” Violin said. “We anticipate this will be similar to what we have seen recently in the obesity field — and we believe we have the advantage of strategic design. CR-001 was crafted specifically to thread the same immunotherapy needle as ivonescimab, putting us in a strong competitive position.” presented by Health IT Accelerating Claim Processing: Strategies to Shorten the Life of a Claim These strategies and practices can significantly shorten the life cycle of claims, leading to quicker resolutions and improved financial outcomes. By Greenway Health Competition includes BioNTech and Instil Bio, both of which struck alliances in the past year with China-based companies for rights to bispecific antibodies that target both PD-1 and VEGF. Both programs are in clinical development in China. Crescent is the fifth company to emerge from Paragon Therapeutics, a firm that conducts biotechnology research and forms new companies around that science. The first Paragon spinout was Apogee Therapeutics, which emerged in late 2022 with a lead drug candidate in development for atopic dermatitis. Last year, Apogee raised more than $300 million in a traditional IPO that came ahead of the start of Phase 1 testing. Crescent’s pipeline of drugs from Paragon includes two preclinical antibody drug conjugates, CR-002 and CR-003. The company isn’t disclosing much detail about either program, but Violin said CR-002 “targets a highly compelling pathway” and the drug offers “the chance to be first in class.” GlycoMimetics was focused on developing treatments for cancer and inflammatory diseases with small molecules that inhibit carbohydrate interactions on the surface of cells. In July, FDA told the company its lead drug candidate, uproleselan, a potential treatment for advanced cases of acute myeloid leukemia, needed an additional clinical trial. Subsequently, the company laid off staff announced it would explore strategic alternatives. Crescent said it intends to determine potential paths forward for uproleselan. The private investment in the newly merged Crescent will be led by Fairmount, Venrock Healthcare Capital Partners, BVF Partners, and an unnamed “large investment management firm.” Other participants include Paradigm BioCapital, RTW Investments, Blackstone Multi-Asset Investing, Frazier Life Sciences, Commodore Capital, Perceptive Advisers, Deep Track Capital, Boxer Capital Management, Soleus, Logos Capital, Driehaus Capital Management, Braidwell LP, and Wellington Management. When the business combination closes, Crescent’s stockholders will own about 96.9% of the company; GlycoMimetics stockholders will own about 3.1%. Crescent believes its capital will be sufficient to last into 2027. By then, Crescent and its peers should have more data demonstrating how their respective bispecific antibody cancer drugs are working in patients. Photo by Flickr user Lengyal Mark via a Creative Commons license

ImmunotherapyPhase 3IPOAcquisitionPhase 1

04 Sep 2024

·www.biospace.com

Apollomics to Present at the H.C. Wainwright 26th Annual Global Investment Conference

FOSTER CITY, Calif., Sept. 04, 2024 (GLOBE NEWSWIRE) -- Apollomics Inc. (Nasdaq: APLM ) (“Apollomics” or the “Company”), a late-stage clinical biopharmaceutical company developing multiple oncology drug candidates to address difficult-to-treat and treatment-resistant cancers, today announced Company management will be presenting at the H.C. Wainwright 26th Annual Global Investment Conference taking place on September 9-11, 2024 virtually and in person at the Lotte New York Palace Hotel in New York, NY. H.C. Wainwright 26th Annual Global Investment Conference Format: Company presentation Presentation Date & Time: Available on demand as of September 9, 2024 at 7:00 am ET Presenters: Guo-Liang Yu, PhD, Chairman and Chief Executive Officer and Matthew Plunkett, PhD, Chief Financial Officer Webcast: Click here Management will be available for virtual one-on-one meetings during the conference. Interested investors should contact their H.C. Wainwright representative to request meetings. The Company’s current presentation may be accessed on the Company website on the Events page under the Investors section. About Apollomics Inc. Apollomics Inc. is an innovative clinical-stage biopharmaceutical company focused on the discovery and development of oncology therapies with the potential to be combined with other treatment options to harness the immune system and target specific molecular pathways to inhibit cancer. Apollomics’ programs include its lead product candidate, vebreltinib, a potent, selective c-Met inhibitor for the treatment of non-small cell lung cancer and other advanced tumors with c-Met alterations, which is currently in a Phase 2 multicohort global clinical trial, and uproleselan, a specific E-Selectin antagonist that has the potential to be used adjunctively with standard chemotherapy to treat acute myeloid leukemia and other hematologic cancers, which is currently in a Phase 3 clinical trial in China. For more information, please visit . Investor Contact: Eric Ribner LifeSci Advisors, LLC (646) 751-4363 eric@lifesciadvisors.com

Phase 2Phase 3

100 Deals associated with Uproleselan

External Link

KEGG	Wiki	ATC	Drug Bank
D11332	-	-	DB14829

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Adult Acute Myeloblastic Leukemia	Phase 3	CN	Apollomics (Hong Kong) Limited	27 Oct 2021
Adult Acute Myeloblastic Leukemia	Phase 3	CN	Zhejiang Crownmab Biotech Co. Ltd.	27 Oct 2021
Refractory acute myeloid leukemia	Phase 3	CN	Apollomics, Inc. (United States)	18 Oct 2021
Acute Myeloid Leukemia	Phase 3	US	National Cancer Institute	28 Mar 2019
Relapsing acute myeloid leukemia	Phase 3	US	GlycoMimetics, Inc.	15 Oct 2018
Relapsing acute myeloid leukemia	Phase 3	AU	GlycoMimetics, Inc.	15 Oct 2018
Relapsing acute myeloid leukemia	Phase 3	CA	GlycoMimetics, Inc.	15 Oct 2018
Relapsing acute myeloid leukemia	Phase 3	FR	GlycoMimetics, Inc.	15 Oct 2018
Relapsing acute myeloid leukemia	Phase 3	IE	GlycoMimetics, Inc.	15 Oct 2018
Relapsing acute myeloid leukemia	Phase 3	IT	GlycoMimetics, Inc.	15 Oct 2018

Clinical Result

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Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03616470 (Phase 3 Trial, ASH2024)	Phase 3	Relapsing acute myeloid leukemia	388	Uproleselan + Chemotherapy	yksyirucxr(sjqxonughx) = wqretmcagl zpopyapcbt (egqviqabwy ) View more	Positive	09 Dec 2024
NCT03616470 (Phase 3 Trial, ASH2024)	Phase 3	Relapsing acute myeloid leukemia	388	Chemotherapy Alone	yksyirucxr(sjqxonughx) = qdnujcaran zpopyapcbt (egqviqabwy ) View more	Positive	09 Dec 2024
NCT04848974 (Phase II Study of Uproleselan Combined with Cladribine and Low-Dose Cytarabine, ASH2024)	Phase 2	Consolidation	37	Uproleselan 800 mg IV	pfkmxqzdkv(fzjnwvmxej) = cphpidflsl dsjbvgufnq (qdhxvdwqyt ) View more	Positive	09 Dec 2024
NCT03616470 (Biospace) Manual	Phase 3	Acute Myeloid Leukemia	388	Uproleselan	dogvdbjpwo(caxfpvaoeb) = rfrfcokxjd urampsjqof (qpqqjjnqtn ) View more	Positive	04 Jun 2024
NCT03616470 (Biospace) Manual	Phase 3	Acute Myeloid Leukemia	388	Placebo	dogvdbjpwo(caxfpvaoeb) = cdwtystoqf urampsjqof (qpqqjjnqtn ) View more	Positive	04 Jun 2024
NCT03616470 (Company_Website) Manual	Phase 3	Acute Myeloid Leukemia	388	Uproleselan	lktcddsdfr(htqwmybfzn) = nfwuncbnhe pcrinhfcdh (awzlhxtdou ) Not Met	Negative	06 May 2024
NCT03616470 (Company_Website) Manual	Phase 3	Acute Myeloid Leukemia	388	placebo	lktcddsdfr(htqwmybfzn) = kzlgbolymj pcrinhfcdh (awzlhxtdou ) Not Met	Negative	06 May 2024
NCT04682405 (CTgov)	Phase 2	Multiple Myeloma	51	melphalan+Uproleselan (Uproleselan + Standard of Care Melphalan)	xfyvbwnbhk(dhrmjwyukv) = teeeosmebs ducgbrjbvv (xupmapjngw, ysiajjnbca - orwdrtsqtd) View more	-	15 Dec 2023
NCT04682405 (CTgov)	Phase 2	Multiple Myeloma	51	Placebo+melphalan (Placebo + Standard of Care Melphalan)	xfyvbwnbhk(dhrmjwyukv) = tmmdsjdwoj ducgbrjbvv (xupmapjngw, pwubazfkvo - qvpskdqiiq) View more	-	15 Dec 2023
NCT04848974 (ASH2023)	Phase 1/2	Acute Myeloid Leukemia	20	Uproleselan + Cladribine + LDAC	tbeuijtmcv(jlodnkvums) = uffahkehds ukdtrpxbrl (fbyzjemksu ) View more	-	10 Dec 2023
NCT05057221 (CTgov)	Phase 1/2	COVID-19	6	Uproleselan	bcojuslzwe(bppnecmkoa) = viahtfjmrl fgolfwagma (glmzaacrwq, jsdtcwpiiy - ioirjpytsc) View more	-	10 Jul 2023
NCT04964505 (ASH2022) Manual	Phase 1	Acute Myeloid Leukemia First line	8	Azacitidine+Venetoclax+Uproleselan	ugbhicyqlu(bhqdwicdqg) = rqzncqddme uqqyfnrtwj (rqssbxzobk ) View more	Positive	15 Nov 2022
NCT04848974 (ASH2022) Manual	Phase 1/2	Relapsing acute myeloid leukemia	10	Cladribine+Cytarabine+Uproleselan	ugbsuqsyee(tmljetatez) = The most common SAEs were ≥ grade 3 neutropenic fever (70%), (including 2 grade 5 events), grade 3 bleeding (10%), and grade 2 thrombosis (5%) cadkyaaitw (igsgkuykus )	Positive	15 Nov 2022
NCT02306291 (Pubmed \| Circulation) Manual	Phase 1/2	Acute Myeloid Leukemia	-	Chemotherapy+Uproleselan	efdrpcwwno(viwbcvwksv) = 10 mg/kg twice daily rfdhayktgl (wfysrojldy )	Positive	20 Sep 2021

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