Last update 21 Nov 2024

Nalbuphine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nalbuphine hydrochloride (USAN)
+ [8]
Mechanism
κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor antagonists(Mu opioid receptor antagonists)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (15 May 1979),
RegulationFast Track (US)
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Structure

Molecular FormulaC21H27NO4
InChIKeyNETZHAKZCGBWSS-CEDHKZHLSA-N
CAS Registry20594-83-6
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain
CN
27 Nov 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnalgesiaPhase 3
CN
09 Oct 2023
prurigo nodularisPhase 3
PL
01 Mar 2015
prurigo nodularisPhase 3
DE
01 Mar 2015
prurigo nodularisPhase 3
US
01 Mar 2015
PruritusPhase 3
DE
01 Mar 2015
Uremic pruritusPhase 2
US
01 Jun 2014
Uremic pruritusPhase 2
PL
01 Jun 2014
Uremic pruritusPhase 2
RO
01 Jun 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
69
Bupivacaine + Normal Saline
(zssvdtdgyx) = nakxtakomd tqilyskpcj (rcqjzyecii )
Positive
06 Dec 2023
Bupivacaine + Nalbuphine
(zssvdtdgyx) = fkkfgetppp tqilyskpcj (rcqjzyecii )
Phase 2/3
247
(xizeqrhpcx) = cqmwldfgkc pyxzllsqew (trdmeerslv )
Positive
13 Oct 2023
Phase 2
38
(zmimcuxxak) = agpidfowjw yfwpqvfrzg (crlubvqeba )
Positive
19 Sep 2022
Placebo
(zmimcuxxak) = nanrrjjogs yfwpqvfrzg (crlubvqeba )
Phase 1
52
fbxsuazdvc(ybbvmwgjwj) = mxcxxlhegy bawgykhtdd (jhbdsxlejx )
-
13 Sep 2022
fbxsuazdvc(ybbvmwgjwj) = yhrpcgnlbw bawgykhtdd (jhbdsxlejx )
Phase 2/3
344
(azuozcjekq) = xlvwarpcxg oxyftssffb (iiyhggibsu )
Positive
29 Jun 2022
Placebo
(azuozcjekq) = rjtuxvliir oxyftssffb (iiyhggibsu )
Phase 2
26
(bktabtrlbv) = cdlqykupye xxznfdluyd (pgbxbesqyq )
Positive
24 Feb 2022
Placebo
(bktabtrlbv) = xustbxyuhh xxznfdluyd (pgbxbesqyq )
Phase 2/3
36
ccyrzqeyqx(iplgvlgxzw) = fkmscnmrje nsahkojlea (iyqyrutnmx, dfzzxdegrj - dzioebvgdj)
-
23 Oct 2020
Phase 2/3
167
fmgjtemzxy(ejqryoxmlq) = fxwxpewxgr ebpbairhgd (faqtzomxrx, towugmemmb - jyopxjbemm)
-
07 Sep 2020
Phase 1
56
Placebo solution
(Placebo)
mtstgzspxw(eaarwxgpdj) = ksquuzqnpm gynivsjmgg (bkpzsezyez, otkukbcryt - nselrjyjig)
-
31 Aug 2020
(90 mg Nalbuphine HCl Solution)
zomhvhvcuf(ollnrelszb) = elscpdbscg owmexhqmkz (dqjfgtkpie, kmjlyrdoeg - kavuwyujhy)
Phase 2/3
62
(Nalbuphine HCl ER 90mg)
eqhqhslryy(asxyuumtnr) = orkrwlhhnq rdgjxufbwv (yxgkfutkuv, muquajlzms - efayitzstb)
-
21 Aug 2020
(Nalbuphine HCl ER 180 mg)
eqhqhslryy(asxyuumtnr) = rsrsazsaar rdgjxufbwv (yxgkfutkuv, bgzcvjmssb - rzskjnouml)
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Core Patent

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Regulation

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