Laparoscopic cholecystectomy is an effective surgical approach for the treatment of gallbladder disorders such as cholecystitis, gallbladder stones or gallbladder polyps. Although the surgical technique for the treatment of cholecystitis with laparoscope shows some gains compared to open surgery, postoperative complications such as abdominal incision pain, nausea and vomiting, or other complications are still challenging issues.
Thus, there is a need to study and evaluate new non-opioid pain medications after laparoscopic cholecystectomy as part of an opioid reduction strategy.the aim of the study is To compare the effectiveness and safety of opioid-free anesthesia versus opioid-based anesthesia in patients undergoing laparoscopic cholecystectomy, focusing on pain management, postoperative recovery, and incidence of adverse effects.

Start Date01 Jan 2025

Sponsor / Collaborator

Assiut University

100 Clinical Results associated with Nalbuphine Hydrochloride

100 Translational Medicine associated with Nalbuphine Hydrochloride

100 Patents (Medical) associated with Nalbuphine Hydrochloride

1,208

Literatures (Medical) associated with Nalbuphine Hydrochloride

15 Jan 2025·The Journal of Maternal-Fetal & Neonatal MedicineQ4 · MEDICINE

Nalbuphine: a candidate for treatment of women overwhelmed with sudden, intense labor pain?

Q4 · MEDICINE

Article

Author: Spiess, Deborah ; Schoppmann, Seraina ; Müller, Daniel ; Zimmermann, Roland ; Burch, Andrea ; Simões-Wüst, Ana Paula

AIMOn very rare occasions, women are overwhelmed with sudden, intense labor pain in the context of ultra-rapid late second stage of labor, especially when the head is crowning. The consequences may comprise serious pelvic floor damage for the mother and hypoxia for the fetus. Drugs like nalbuphine for immediate maternal analgesia and sedation would be helpful. This mixed opioid agonist-antagonist, that was used in obstetric anesthesia in the 1980s, acts quickly while side effects for the mother are minor. To better estimate possible complications for the fetus of a use shortly before birth, it is important to find out how quickly i.v. administered nalbuphine reaches fetal circulation. Therefore, we characterized the transplacental transfer of nalbuphine using an ex vivo model.METHODSPlacentas were obtained from cesarean sections after mothers gave their informed consent. Upon cannulation of one cotyledon, nalbuphine was added to the maternal circuit (calculated final concentration 100 ng/mL) and the ex vivo placenta perfusions were performed. To determine nalbuphine transfer from maternal to fetal circuit in the successful perfusions (n = 5), samples were collected at different time points.RESULTSAt perfusion start, the measured initial nalbuphine concentrations in the maternal and fetal circuits are 93.1 and <0.1 ng/mL, respectively. After 5 min of placenta perfusion, 2.5 ng/mL nalbuphine (i.e. 3% of the initial nalbuphine concentration in the maternal circuit) is reached in the fetal circuit; after 15 and 30 min, 9.7 and 15.8 ng/mL (approximately 10 and 16% of initial maternal, respectively).CONCLUSIONSOnly a small amount of nalbuphine is likely to reach the fetus during the first minutes after (i.v.) maternal administration. Nalbuphine might be a valuable candidate for clinical use in the i.v. analgesia and sedation of women overwhelmed with sudden labor pain in the context of ultra-rapid second stage of labor.

02 Jan 2025·Journal of Drug Targeting

Exploring nalbuphine loaded chitosan nanoparticles for effective pain management through intranasal administration: a comparative study

Article

Author: Rajagopal, Mogana ; Janakiraman, Ashok Kumar ; Sharma, Nitin ; Ram Mani, Ravishankar ; Nishad, Dhruv Kumar ; Goel, Bhawna ; Karwasra, Ritu ; Tayyab, Saad ; Khanna, Kushagra ; Kumar, Abhishek

BACKGROUNDIntranasal drug delivery shows potential for brain access via olfactory and trigeminal routes.PURPOSEThis work aimed to ensure brain availability of nalbuphine via the nasal route.METHODChitosan based nanoparticles loaded with nalbuphine were successfully prepared using ionic gelation method and characterised.RESULTSEM results revealed that the nanoparticles were spherical in shape, with an average size of 192.4 ± 11.6 nm. Zeta potential and entrapment efficiency was found 32.8 mV and 88.43 ± 7.75%, respectively. The X-ray diffractometry and DSC results unravel a profound understanding on the physical and thermal characteristics. The in-vitro release of nalbuphine from the nanoparticles was biphasic, with an initial burst release followed by a slow-release profile. In-vitro cell study on HEK-293 cells and microscopic images of brain tissue confirmed the safety profile of formulation. In-vivo efficacy studies on animal confirmed the effectiveness of developed intranasal formulation as compared to the standard therapy. The in-vivo pharmacokinetic studies showed that the prepared nanoparticles were able to efficiently deliver nalbuphine to the brain in comparison to the other body organs. Gamma scintigraphy images showed retention of the drug in the brain. Furthermore, the efficacy studies confirmed that the nanoparticles were found significantly more effective than the marketed formulation in pain management.

01 Jan 2025·The Journal of Clinical Pharmacology

Efficacy of Low‐Dose Scopolamine and Palonosetron in Reducing Immediate Post‐Gastrointestinal Endoscopy Nausea and Vomiting: A Prospective, Randomized, Controlled Study

Article

Author: Lin, Jianghuai ; Gu, Yu ; Cai, Zhiming ; Lin, Yingzi ; Wu, Huanghui

AbstractThis study aimed to assess the incidence of post‐discharge nausea and vomiting (PDNV) following sedation with nalbuphine and etomidate and to evaluate the prophylactic effects of scopolamine in reducing PDNV. A two‐stage prospective clinical trial was conducted. The first part involved an observational study of 77 subjects to assess the PDNV incidence post‐sedation with nalbuphine, etomidate, and propofol. The second part compared the effectiveness of palonosetron 0.075 mg (P group), scopolamine 0.1 mg (S group), and their combination (PS group) in reducing PDNV. The primary endpoint was the incidence of PDNV within 8 h post‐sedation. Secondary outcomes included PDNV frequency and severity at 8–24, 0–24, and 24–48 h and side effects of medications. The incidence of PDNV within 8 h post‐sedation was 37.66% (29/77). The PS group showed a significantly lower PDNV rate of 2.56% within 8 h, compared to the P group (35.71%, P < .001), S group (19.64%, P < .001), and control group (38.39%, P < .001), respectively. The S group (19.64%) also had a lower rate than the P group (35.71%, P = .007) and the control group (38.39%, P = .002). Subgroup analysis suggested a potential differential effect of palonosetron in reducing vomiting among male patients undergoing gastrointestinal procedures. The combination therapy was also associated with fewer cases of mild or no nausea and vomiting. In summary, the incidence of PDNV following sedation with nalbuphine and etomidate was notably high. The combination of scopolamine and palonosetron was more effective in preventing PDNV, with implications for improved post‐sedation care.

News (Medical) associated with Nalbuphine Hydrochloride

08 Jan 2025

·ir.trevitherapeutics.com

Trevi Therapeutics Announces Company Updates Ahead of 14th Annual LifeSci Partners Corporate Access Event Held During the J.P. Morgan Healthcare Conference

Last patient completed the Phase 2a RIVER trial in refractory chronic cough (RCC) in early January and topline results continue to be expected in the first quarter of 2025 Approximately 80% of enrollment complete in the Phase 2b CORAL trial in idiopathic pulmonary fibrosis (IPF) patients with chronic cough and topline results continue to be expected in the first half of 2025 NEW HAVEN, Conn., Jan. 8, 2025 /PRNewswire/ -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of patients with chronic cough in idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC), today announced business updates ahead of its participation in the 14th Annual LifeSci Partners Corporate Access Event taking place in San Francisco, CA, from January 13-15, 2025. This event takes place during the week of the annual J.P. Morgan Healthcare Conference. "We look forward to important readouts on our IPF chronic cough and RCC trials in the first half of the year, which follow our strong execution in 2024," said Jennifer Good, President and CEO of Trevi Therapeutics. "We ended last year with positive outcomes in both the sample size re-estimation (SSRE) analysis of the Phase 2b CORAL trial in IPF patients with chronic cough and in our Human Abuse Potential study. These trials were key milestones for our IPF clinical trial and overall development program. This clinical development progress brings us closer to potentially providing a differentiated therapy to patients who suffer from chronic cough and have no approved therapies available to them in the U.S." Key Company Highlights The last patient completed their final visit in the Phase 2a RIVER trial in RCC, which was designed to enroll approximately 60 patients, at the beginning of January 2025. Topline results for the trial continue to be expected in the first quarter of 2025. The positive outcome for the sample size re-estimation analysis for the Phase 2b CORAL trial in IPF patients with chronic cough was announced in December 2024, reaffirming the original sample size for the trial (N=160). The trial is now approximately 80% enrolled and topline results continue to be expected in the first half of 2025. The Company estimates its cash, cash equivalents, and marketable securities were $107.6 million as of December 31, 2024, providing an expected cash runway into the second half of 2026. The Company's estimate of its cash, cash equivalents, and marketable securities as of December 31, 2024, included in this press release is a preliminary estimate based on information available as of January 8, 2025, and its actual cash, cash equivalents, and marketable securities may be different from this preliminary estimate. In addition, the Company's independent registered public accounting firm has not audited or reviewed this preliminary estimate. About Trevi Therapeutics, Inc. Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC). Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), which are opioid receptors that play a key role in controlling cough hypersensitivity. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency.   Chronic cough is a highly prevalent disease in IPF patients, impacting up to 85% of the IPF population. There are ~140,000 U.S. IPF patients and the impact of chronic cough is significant with patients coughing up to 1,500 times per day. This consistent cough and associated damage may lead to worsening disease, a higher risk of progression, death, or need for lung transplant. Chronic cough also often leads to a decline in patients' social, physical, and psychological quality of life. There are no approved therapies for the treatment of chronic cough in IPF and current off-label treatment options provide minimal benefit to patients.  Refractory chronic cough affects approximately 2-3 million adults in the U.S. and is caused by cough reflex hypersensitivity in both the central and peripheral nerves. It is highly disruptive and accompanied by a wide range of complications, ranging from urinary incontinence in females to sleep disruption and social embarrassment that causes significant social and economic burdens for patients and those around them. Haduvio is being developed for the treatment of moderate to severe RCC. There are also no approved therapies for RCC in the U.S.   Trevi intends to propose Haduvio as the trade name for oral nalbuphine ER. Its safety and efficacy have not been evaluated by any regulatory authority.   For more information, visit www.TreviTherapeutics.com and follow Trevi on X (formerly Twitter) and LinkedIn. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are subject to risks and uncertainties and actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding Trevi's business plans and objectives, including future plans or expectations for Haduvio and plans and timing with respect to clinical trials and clinical data, and statements regarding Trevi's expected cash runway and other statements containing the words "believes," "anticipates," "plans," "expects," and similar expressions. Risks that contribute to the uncertain nature of the forward-looking statements include: uncertainties regarding the success, cost and timing of Trevi's product candidate development activities and ongoing and planned clinical trials; the risk that positive data from a clinical trial may not necessarily be predictive of the results of later clinical trials in the same or a different indication; uncertainties regarding Trevi's ability to execute on its strategy; uncertainties with respect to regulatory authorities' views as to the data from Trevi's clinical trials and next steps in the development path for Haduvio in the United States and foreign countries; uncertainties inherent in estimating Trevi's cash runway, future expenses and other financial results, including Trevi's ability to fund future operations, including clinical trials, as well as other risks and uncertainties set forth in Trevi's quarterly report on Form 10-Q for the quarter ended September 30, 2024 filed with the Securities and Exchange Commission and in subsequent filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Trevi undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Investor Contact Jonathan Carlson Trevi Therapeutics, Inc. (203) 654 3286 carlsonj@trevitherapeutics.com Media Contact Rosalia Scampoli 914-815-1465 rscampoli@marketcompr.com SOURCE Trevi Therapeutics, Inc.

Phase 2Financial Statement

12 Dec 2024

·www.prnewswire.com

Trevi Therapeutics Announces Positive Outcome from Sample Size Re-estimation Resulting in No Change to the Current Sample Size for the Phase 2b CORAL Trial in Idiopathic Pulmonary Fibrosis Patients with Chronic Cough

Independent Data Monitoring Statistician reaffirmed current sample size to remain at N=160 The trial has reached 75% of the targeted enrollment, and topline results continue to be expected in the first half of 2025 NEW HAVEN, Conn., Dec. 12, 2024 /PRNewswire/ -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of patients with chronic cough in idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC), today announced the positive outcome from the planned sample size re-estimation (SSRE) for the ongoing Phase 2b CORAL trial in IPF patients with chronic cough, which requires no change to the current sample size for the trial (N=160). The trial has reached 75% of the targeted enrollment, and topline results from the full trial continue to be expected in the first half of 2025. The SSRE analysis was conducted on the highest dose (108mg twice daily) in the trial after 50% of the initial targeted trial enrollment, or 80 patients, completed the six weeks of treatment. Based on the SSRE analysis, it was recommended that the CORAL trial should continue as planned to maintain the pre-specified conditional power of 80% or greater. The other two potential pre-specified outcomes of the SSRE analysis were an increase in the sample size or futility. "We are pleased that the SSRE outcome supports the continued execution of the CORAL trial with the total number of patients as originally planned," said Jennifer Good, President and CEO of Trevi Therapeutics. "This positive SSRE outcome is reassuring and confirms the key powering assumptions of the trial design. We believe this is additional confirmation of the strong efficacy observed in the Phase 2a CANAL trial in IPF cough and is an important milestone reaffirming our belief in Haduvio's best-in-class and first-in-class potential for patients with IPF chronic cough where there are no approved therapies." Phase 2b IPF Chronic Cough Trial Design (CORAL): The CORAL trial is a double-blind, randomized, placebo-controlled, parallel-arm trial evaluating three doses of Haduvio (27mg, 54mg, and 108mg twice daily) compared to placebo in IPF patients with chronic cough. Approximately 160 IPF patients with chronic cough will be randomized 1:1:1:1 to one of three Haduvio doses or placebo for a period of 6 weeks. This includes an initial 2-week titration period to the target dose followed by 4 weeks of fixed dosing. The primary efficacy endpoint for the trial is the relative change in 24-hour cough frequency at the end of Week 6 versus baseline for Haduvio compared to placebo, as measured with an objective cough monitor (VitaloJAK®). The trial will also explore secondary endpoints, including patient reported outcome measures for cough. About Trevi Therapeutics, Inc. Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC). Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), which are opioid receptors that play a key role in controlling cough hypersensitivity. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency. Chronic cough is a highly prevalent disease in IPF patients, impacting up to 85% of the IPF population. There are ~140,000 U.S. IPF patients and the impact of chronic cough is significant with patients coughing up to 1,500 times per day. This consistent cough and associated damage may lead to worsening disease, a higher risk of progression, death, or need for lung transplant. Chronic cough also often leads to a decline in patients' social, physical, and psychological quality of life. There are no approved therapies for the treatment of chronic cough in IPF and current off-label treatment options provide minimal benefit to patients. Refractory chronic cough affects approximately 2-3 million adults in the U.S. and is caused by cough reflex hypersensitivity in both the central and peripheral nerves. It is highly disruptive and accompanied by a wide range of complications, ranging from urinary incontinence in females to sleep disruption and social embarrassment that causes significant social and economic burdens for patients and those around them. Haduvio is being developed for the treatment of moderate to severe RCC. There are also no approved therapies for RCC in the U.S. Trevi intends to propose Haduvio as the trade name for oral nalbuphine ER. Its safety and efficacy have not been evaluated by any regulatory authority. For more information, visit and follow Trevi on X (formerly Twitter) and LinkedIn. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are subject to risks and uncertainties and actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding Trevi's business plans and objectives, including future plans or expectations for Haduvio and plans and timing with respect to clinical trials and clinical data, and other statements containing the words "believes," "anticipates," "plans," "expects," and similar expressions. Risks that contribute to the uncertain nature of the forward-looking statements include: uncertainties regarding the success, cost and timing of Trevi's product candidate development activities and ongoing clinical trials; the risk that positive data from a clinical trial, or from the sample size re-estimation analysis announced in this press release, may not necessarily be predictive of the results of later clinical trials in the same or a different indication; uncertainties regarding Trevi's ability to execute on its strategy; uncertainties with respect to regulatory authorities' views as to the data from Trevi's clinical trials and next steps in the development path for Haduvio in the United States and foreign countries, as well as other risks and uncertainties set forth in Trevi's quarterly report on Form 10-Q for the quarter ended September 30, 2024 filed with the Securities and Exchange Commission and in subsequent filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Trevi undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Investor Contact Katie Barrett Trevi Therapeutics, Inc. 203-304-2499 [email protected] Media Contact Rosalia Scampoli 914-815-1465 [email protected] SOURCE Trevi Therapeutics, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Phase 2Clinical Result

04 Dec 2024

·endpts.com

AstraZeneca's new EVP of international amid China investigation; Janux’s $300M offering

Plus, news about Arrakis, Eli Lilly, Everest Medicines, Teva, Rondo Therapeutics, Trevi Therapeutics, Foresee Pharmaceuticals and Revolution Medicines: AstraZeneca taps new leader to run China business: The drugmaker named Iskra Reic as EVP of international, putting her in charge of its China business after Leon Wang was placed on leave while under investigation there. Wang was EVP of international and president of China. Reic, who launched the company’s vaccines and immune therapies unit, has been with AstraZeneca since 2001. — Jaimy Lee Janux’s $300M offering: The biotech is raising money after its stock soared on Tuesday thanks to early prostate cancer data . It’s been reported as a takeover target in the past. — Kyle LaHucik Arrakis shares first look at preclinical myotonic dystrophy type 1 data: Earlier this year, the RNA-targeted small molecule biotech helmed by industry veteran Michael Gilman shifted its focus from a lead cancer program to DM1, Endpoints News reported in March. “While there have been serendipitous discoveries of small molecule drugs that bind to RNA, we believe this is one of the clearest examples of a rationally designed small molecule that has been purpose-built to address an RNA disease target,” Gilman said in a Wednesday release. — Kyle LaHucik Lilly joins hot T cell engager space: The pharma giant, mostly in the news for its obesity medicines, has inked a cancer deal. It’s paying an undisclosed amount to California startup Rondo Therapeutics for a CD28-co-stimulatory bispecific antibody for an undisclosed cancer target. Multiple large pharmas have done T cell engager deals in recent months. — Kyle LaHucik Everest Medicines details early data for BTK inhibitor: In the ongoing Phase 1b/2a trial in China for patients with primary membranous nephropathy, 9 out of 11 (81.8%) patients taking the lowest dose achieved overall clinical remission after 36 weeks, and 10 out of 11 (91%) achieved immunological complete remission. In patients on the highest dose, 6 out of 7 (85.7%) patients achieved overall clinical remission. — Katherine Lewin Teva’s Ajovy bests placebo in pediatric migraine trial: Over 12 weeks, Ajovy “significantly” reduced monthly migraine days and monthly headache days compared to placebo in patients between six and 17 years old. The full data are set to be presented at the European Headache Congress in the Netherlands this week. — Katherine Lewin Trevi’s topline data for chronic cough drug: The human abuse potential study , which enrolled patients who are recreational drug users, showed a statistically significant lower “drug liking” for two doses of Trevi’s nalbuphine compared to butorphanol, a narcotic for pain with a high risk for addiction. But its stock $TRVI was down about 4% on Wednesday morning. — Katherine Lewin Foresee’s $42M raise: The Taipei and US biotech, which markets the prostate cancer drug Camcevi, secured the money by selling 18 million shares. — Kyle LaHucik Revolution Medicines upsized its public offering to $750 million, up from the $600 million it initially planned to raise . — Jaimy Lee

Clinical ResultImmunotherapy

100 Deals associated with Nalbuphine Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D00843	Nalbuphine Hydrochloride	N02AF02	DB00844

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Pain	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	27 Nov 2013

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Analgesia	Phase 3	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	09 Oct 2023
prurigo nodularis	Phase 3	PL	Trevi Therapeutics, Inc.	01 Mar 2015
prurigo nodularis	Phase 3	DE	Trevi Therapeutics, Inc.	01 Mar 2015
prurigo nodularis	Phase 3	US	Trevi Therapeutics, Inc.	01 Mar 2015
Pruritus	Phase 3	DE	Trevi Therapeutics, Inc.	01 Mar 2015
Uremic pruritus	Discovery	US	Trevi Therapeutics, Inc.	01 Jun 2014
Uremic pruritus	Discovery	PL	Trevi Therapeutics, Inc.	01 Jun 2014
Uremic pruritus	Discovery	RO	Trevi Therapeutics, Inc.	01 Jun 2014

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


PRNewswire Manual	Not Applicable	Chronic cough	-	Placebo	akfjucrsbv(iyqiufzzzo) = lsktgfyyoj yxqxrfvgki (jrdjihqxjv ) View more	Positive	03 Dec 2024
				IV Butorphanol 6mg	akfjucrsbv(iyqiufzzzo) = mytejuxgvp yxqxrfvgki (jrdjihqxjv ) View more
NCT02820051 (CTgov)	Not Applicable	Sedation	102	Transcutaneous CO2 monitor+Midazolam+Lidocaine+nalbuphine (Midazolam)	divdniunuh(fgiljbjjrt) = xeepxipanw qfkvybcksg (dhhpjypduc, tklafkdqpt - gkaizsoihq) View more	-	02 Dec 2024
				Transcutaneous CO2 monitor+Propofol+Lidocaine+nalbuphine (Propofol)	divdniunuh(fgiljbjjrt) = bxlwaewlxs qfkvybcksg (dhhpjypduc, jxzppsmhit - zckuhvjgfj) View more
NCT05041270 (ZU-IRB#:7045-15-8-2021, Pubmed \| BMC Anesthesiol)	Not Applicable	-	69	Bupivacaine + Normal Saline	(dhbtkedzkg) = vhzsbobtyw difsrrsknl (ygfdoqfaez ) View more	Positive	06 Dec 2023
				Bupivacaine + Nalbuphine	(dhbtkedzkg) = vtyvjiiwpu difsrrsknl (ygfdoqfaez ) View more
NCT03497975 (PRISM, EADV2023) Manual	Phase 2/3	prurigo nodularis	247	Haduvio	(gdzvhxxtwb) = qaaekmrywp ouhkoftnji (cqojmybyes ) View more	Positive	13 Oct 2023
NCT04030026 (CANAL, Corporate Publications) Manual	Phase 2	Idiopathic Pulmonary Fibrosis \| Chronic cough	38	Haduvio	(otmrfhpoct) = wxnmeogvpy jrzkjwlkus (posdocwveb ) View more	Positive	19 Sep 2022
				Placebo	(otmrfhpoct) = foevybufeh jrzkjwlkus (posdocwveb ) View more
NCT03059511 (Pubmed \| Arch Dis Child)	Phase 1	-	52	Intranasal nalbuphine	zpwiihfvpl(sijfqohheq) = qvqpqjhaee onbgpmlsna (ljgwvgbcwd )	-	13 Sep 2022
				Intravenous nalbuphine	zpwiihfvpl(sijfqohheq) = ujffpunczg onbgpmlsna (ljgwvgbcwd )
NCT03497975 (PRISM, Corporate Publications) Manual	Phase 2/3	prurigo nodularis	344	Haduvio	(csacixahkp) = qpijttqcjf cecvkysrsh (jskwpdppyj ) View more	Positive	29 Jun 2022
				Placebo	(csacixahkp) = kxlfzgofjw cecvkysrsh (jskwpdppyj ) View more
NCT04030026 (CANAL, Biospace) Manual	Phase 2	Idiopathic Pulmonary Fibrosis \| Chronic cough	26	Haduvio	(klqpeuvozi) = gddvhpecrx yyshzgxqnr (tpwpzcpyid )	Positive	24 Feb 2022
				Placebo	(klqpeuvozi) = rzmqpxchdm yyshzgxqnr (tpwpzcpyid )
NCT02174432 (CTgov)	Phase 2/3	prurigo nodularis	36	nalbuphine HCl ER	cxgiyewczz(nuftdazlqp) = jlvhrymihi dqfbjncvie (addogwkpdq, giitvmqdqx - ohttodwdwl) View more	-	23 Oct 2020
NCT02143648 (CTgov)	Phase 2/3	Uremic pruritus	373	nalbuphine HCl ER tablets 60 mg BID (Nalbuphine HCl ER 60mg)	huskmvztls(hixfldqffo) = oirtqlqwsn hzbxkzpotp (abrmzicptp, brrmekgvic - pbnogmphvz) View more	-	07 Sep 2020
				nalbuphine HCl ER tablets 120mg BID (Nalbuphine HCl ER 120mg)	huskmvztls(hixfldqffo) = tencoalkza hzbxkzpotp (abrmzicptp, eednrhhsdi - shkvwkdqio) View more

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