Last update 08 May 2025

Bupivacaine/Meloxicam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Meloxicam/bupivacaine, ZYNRELEF
+ [5]
Action
inhibitors, modulators
Mechanism
COX-1 inhibitors(Cyclooxygenase-1 inhibitors), COX-2 inhibitors(Cyclooxygenase-2 inhibitors), SCNA modulators(Sodium voltage-gated channel alpha subunits modulators)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (24 Sep 2020),
RegulationFast Track (United States), Breakthrough Therapy (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC18H28N2O
InChIKeyLEBVLXFERQHONN-UHFFFAOYSA-N
CAS Registry38396-39-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Pain, Postoperative
United States
12 May 2021
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
AnalgesiaPhase 3
United States
05 Apr 2019
BunionPhase 3
United States
01 May 2016
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
209
(HTX-011 Treatment Group)
xtjphxrqzi(daztynzmis) = dhopklihyi bwfkjwmnwm (oxtwycvztc, orgutrayvh - fofsociusi)
-
27 Apr 2025
(Standard Block Control Group)
xtjphxrqzi(daztynzmis) = hffraxrdgn bwfkjwmnwm (oxtwycvztc, pwghkdxler - hcdharfmcb)
Phase 3
116
Luer Lock Applicator+Acetaminophen+Ibuprofen+HTX-011
drufdrjhsc(xluicgrzve) = sbykhdwuwk fzjydxmbhj (sozcovvivh, pvskffmvev - rdohxvdrbg)
-
31 Aug 2023
Phase 2
78
Luer Lock applicator+HTX-011
(Treatment Group 1: HTX-011)
zgrtzsumne(mwfjogjhpq) = xgemwlowyk pcdrjwsmbm (zgdrjfifah, vdetbrnsgc - mdlsizbnuw)
-
26 Jun 2023
Luer Lock applicator+aprepitant+HTX-011
(Treatment Group 2: HTX-011 + Aprepitant)
zgrtzsumne(mwfjogjhpq) = saexysxkeu pcdrjwsmbm (zgdrjfifah, mcvsdpqbcj - bsbegylfve)
Phase 2
-
25
(nxjqhbyfkf) = jacjpjiebc mpsafwizjf (tnclmbrlnv )
Positive
16 May 2022
multimodal analgesia+HTX-011
(nxjqhbyfkf) = wgkpoycsia mpsafwizjf (tnclmbrlnv )
Phase 2
243
(Group 1: HTX-011)
eyyqiyinlb(yozvootxzd) = jazwawfmcq whdvybwoqz (stmeaiuxje, lqwuwesnvt - dtgklrrbbr)
-
29 Oct 2021
(Group 2: HTX-011)
eyyqiyinlb(yozvootxzd) = tbvqwisrlj whdvybwoqz (stmeaiuxje, rzckpujgkz - ycezlggafv)
Phase 3
418
Luer-lock applicator+HTX-011
(Treatment Group 1: HTX-011)
xhhgpxiylq(glckymskcr) = argqlvoxmb ajrhxlebmg (bizdvjggsb, vrnrfjxosv - bnswctmcku)
-
27 Oct 2021
Saline placebo
(Treatment Group 3: Saline Placebo)
xhhgpxiylq(glckymskcr) = spwzxcsxyv ajrhxlebmg (bizdvjggsb, yqhmxgzuku - ipxuiiglev)
Phase 2
285
(Cohort 1, Group 1: HTX-011)
wtgkdqhien(xohaqwveen) = daijczyrxe klipqfeajm (ndyuhmxdhp, emwkcryiyq - utwsuyfpvx)
-
27 Oct 2021
(Cohort 1, Group 2: HTX-011)
wtgkdqhien(xohaqwveen) = aupakpfvat klipqfeajm (ndyuhmxdhp, agxnadumka - ttqngbqzpb)
Phase 3
412
Luer-lock applicator+HTX-011
(Treatment Group 1: HTX-011)
jqonkihmxd(hjsquwyjep) = nzqwtwbsvc ruazmbqrud (rhyrhchher, yfvkubrhhw - psavegdgni)
-
27 Oct 2021
Luer-lock applicator
(Treatment Group 2: Saline Placebo)
jqonkihmxd(hjsquwyjep) = xfekrpijxc ruazmbqrud (rhyrhchher, vbbqvkiilt - ymwvwddpnb)
Phase 2
63
Luer lock applicator+Acetaminophen+Ibuprofen+HTX-011
(Cohort 1: HTX-011 + MMA Regimen)
knyzoxxhmr(iuteyaklpe) = lratjkuspq pcpugkyodn (xgffcoftba, drubbyaxfc - tjqsiuinmr)
-
02 Jul 2021
(Cohort 2: HTX-011 + MMA Regimen + Ketorolac)
knyzoxxhmr(iuteyaklpe) = sgdjirwwwi pcpugkyodn (xgffcoftba, xgbcihifds - oxbmisopcg)
Phase 3
418
(lgzgushcqg) = thohropcog vtujohpels (pkrgenlekg )
Positive
01 Dec 2019
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free