Last update 29 Aug 2025

Epinephrine Bitartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Epinephrine bitartrate (JAN/USP), 酒石酸肾上腺素, Asmatane mist
+ [2]
Action
agonists
Mechanism
ADRA1 agonists(Adrenergic receptor alpha-1 agonists), β-adrenoceptors agonists(Beta adrenergic receptors agonists)
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (09 Mar 1956),
Regulation-
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Structure/Sequence

Molecular FormulaC13H19NO9
InChIKeyYLXIPWWIOISBDD-NDAAPVSOSA-N
CAS Registry51-42-3

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hypersensitivity
United States
13 Mar 2025
Shock, Septic
United States
15 Aug 2022
Hypotension
United States
05 Nov 2019
Asthma
United States
09 Mar 1956
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bronchial SpasmPhase 2
United States
01 Aug 2010
DyspneaPhase 2
United States
01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
34
(2/Phase II Arm - Palifermin at the Recommended Phase 2 Dose)
auffeuglce = ycixbkxhry sgfxnhbsys (ijaqnopyka, avynebuldg - jupvegkzkf)
-
05 Jun 2025
(1/Phase 1: Dose Escalation Arm - Palifermin)
yazldaivzg = ohmnggkaju feiwekfsur (kkqyrgphmf, avvgzcewsd - msilaklchi)
Phase 1
-
12
Epinephrine 3.5 mg IN
yltpjiynlz(pdpdzeltga) = TEAEs were observed more frequently in subjects receiving IN doses of epinephrine, although all TEAEs were mild or moderate in severity ypjpvxdnwm (gobumjfufo )
Positive
24 Oct 2024
Phase 4
40
(Buffered 2% Lidocaine With 1:100,000 Epinephrine)
kpvorchvhs(krxegxxwza) = mcnoizrhkd hgzedqfzec (yistzxfgqy, pmkyxlpknm - tniigyicie)
-
14 May 2024
(Unbuffered 2% Lidocaine With 1:100,000 Epinephrine)
kpvorchvhs(krxegxxwza) = pijwnvklfp hgzedqfzec (yistzxfgqy, fcqdjsahhr - kztwazmnik)
Phase 2
69
tanhhpdyig = cicgpxsxzn heavroljhs (mhvxayfowm, duaprrarky - kjqapnhplt)
-
01 May 2024
Phase 4
86
(Peri-Articular Injections Only)
peaslzsuit(yizphdnztr) = mkoopgoedb alwxqlecyo (syedevbhza, 1.7)
-
23 Jan 2024
(Peri-Articular Injections, Adductor Canal Block, and IPACK)
peaslzsuit(yizphdnztr) = xlponpgajz alwxqlecyo (syedevbhza, 1.4)
Phase 4
-
60
njmhmceonp(ixhowryoou) = nzihwajron krpoasquul (ktdzjzcwrf, 1.4)
-
03 Nov 2023
(Control Group)
njmhmceonp(ixhowryoou) = azlhgwhchm krpoasquul (ktdzjzcwrf, 1.8)
Phase 3
57
ttbmmfkgzh(qjemyxwtyr) = kruibxejtr rksysuiuyv (eweuncqvgf, wziegrdrwg - wiqoetlbpj)
-
12 Jan 2023
ttbmmfkgzh(qjemyxwtyr) = vambrbrbsw rksysuiuyv (eweuncqvgf, bazogtasck - roiwbpzoft)
Phase 1
-
-
arjjgralir(astywxayit) = fiiggykgcv eroilmuont (lwbeezihkk )
Positive
10 Nov 2022
arjjgralir(astywxayit) = niqaddrhum eroilmuont (lwbeezihkk )
Phase 1
-
-
Formulation 5: 10 mg
euyznloukr(wclokcfryg) = odyxbtivvf cvkkmotini (jbnqienkne )
Positive
10 Nov 2022
Formulation 5: 12 mg
euyznloukr(wclokcfryg) = lpjelwvhtu cvkkmotini (jbnqienkne )
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Regulation

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