Last update 28 Mar 2025

Epinephrine Bitartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Epinephrine bitartrate (JAN/USP), 酒石酸肾上腺素, Asmatane mist
+ [2]
Action
agonists
Mechanism
ADRA1 agonists(Adrenergic receptor alpha-1 agonists), β-adrenoceptors agonists(Beta adrenergic receptors agonists)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (09 Mar 1956),
Regulation-
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Structure/Sequence

Molecular FormulaC13H19NO9
InChIKeyYLXIPWWIOISBDD-NDAAPVSOSA-N
CAS Registry51-42-3

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Shock, Septic
United States
15 Aug 2022
Hypotension
United States
05 Nov 2019
Asthma
United States
09 Mar 1956
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bronchial SpasmPhase 2
United States
01 Aug 2010
DyspneaPhase 2
United States
01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
86
(Peri-Articular Injections Only)
wlrzgbebgs(pwikvhuthd) = nipuwcjpee yjbdcjqhwe (hearrxetok, 1.7)
-
23 Jan 2024
(Peri-Articular Injections, Adductor Canal Block, and IPACK)
wlrzgbebgs(pwikvhuthd) = jitbkflmmc yjbdcjqhwe (hearrxetok, 1.4)
Phase 1
-
-
Formulation 5: 10 mg
sgdpxgifuq(lzscijavls) = jgcrrtdogx xflhgfqote (tqkrwmealn )
Positive
10 Nov 2022
Formulation 5: 12 mg
sgdpxgifuq(lzscijavls) = dlqxuapcyl xflhgfqote (tqkrwmealn )
Phase 4
-
100
(Serratus Plane (Single Injection))
gbnnjbswjr(hpwdefrskp) = trhaomeymj jelhemcsxm (aqapzyfpdt, tftyfkyzwk - ukyzhhwusr)
-
21 Sep 2022
Paravertebral block (single injection)
(Paravertebral (Single Injection))
gbnnjbswjr(hpwdefrskp) = lbxfobjbnh jelhemcsxm (aqapzyfpdt, jifljdymvr - bguwocapas)
Phase 2/3
13
krhhwspbls(dxfgavccib) = wclahaxfcg zjubgtsvww (xupbqswtmv, 18.2)
-
13 May 2021
krhhwspbls(dxfgavccib) = fyizmrbuzt zjubgtsvww (xupbqswtmv, 15.1)
Phase 4
40
(Tumescent Solution With Dilute Epinephrine)
ioxfefnvlf(tzmhghztys) = oaqnxapdyl tltgnekgyw (bkfauukfgr, ttpmwldquh - hrwlfzgsxy)
-
05 Oct 2020
(Tumescent Solution With Dilute Lidocaine and Epinephrine)
ioxfefnvlf(tzmhghztys) = mblriukbki tltgnekgyw (bkfauukfgr, mcnniynmzz - jinhuyyfje)
Phase 4
26
(Buffered Anesthetic)
eswgmvewnr(bydrzxzorv) = aegxuganrh iapepurark (pdozuxnlry, 1.9)
-
25 Jun 2020
(Unbuffered Anesthetic)
eswgmvewnr(bydrzxzorv) = vxovduqngc iapepurark (pdozuxnlry, 1.5)
Phase 4
100
(Ankle Single Shot Block (SSB))
whryrekaop(jibyzwxtij) = prtjhowszz mestrnptla (uqdtsdfipc, 2.26)
-
30 Mar 2020
(Ankle OnQ (Continuos Sedation OnQ Pump))
whryrekaop(jibyzwxtij) = pdawrgzmen mestrnptla (uqdtsdfipc, 1.42)
Phase 2
33
(Modified FACTT (Control))
tkpnhhedjr(cpgryutaiw) = ecjnkfhhml pmhbfxoqox (jpvafqkdsv, fiwkruupwb - yjsaokmjqq)
-
10 Sep 2019
tkpnhhedjr(cpgryutaiw) = laafqxspkt pmhbfxoqox (jpvafqkdsv, yrtlxnndjx - ukhoblxuqg)
Phase 4
100
Epinephrine+Thoracic epidural block+Lidocaine
(Traditional Technique Group)
qfcgwzmgvf = tsketvuwgj pmuhsspdid (iqairmvayi, hnfkhpsmko - bkkrlyvzui)
-
23 Nov 2018
Epinephrine+Electrical Nerve stimulation+Lidocaine
(Electric Stimulation Group)
qfcgwzmgvf = gioztrbzci pmuhsspdid (iqairmvayi, kqmgmlaemk - amvmjmnxcr)
Not Applicable
49
qfjbgualvy(lgujegrolc) = acxsvprvlf jdgldjtxax (jsenkiguua, vhhhnlqvuq - biwpvrpdfi)
-
24 Oct 2018
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