Last update 08 Oct 2025

Bupivacaine liposome

Overview

Basic Info

Drug Type
Small molecule drug, Liposomal Drug
Synonyms
Bupivacaine liposome gel-Probudur, Bupivacaine-pMVL(Pacira), Liposomal bupivacaine
+ [10]
Target
Action
blockers
Mechanism
SCNA blockers(Sodium voltage-gated channel alpha subunits blockers)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Oct 2011),
Regulation-
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Structure/Sequence

Molecular FormulaC18H28N2O
InChIKeyLEBVLXFERQHONN-UHFFFAOYSA-N
CAS Registry38396-39-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
United States
28 Oct 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Back PainPhase 3
United States
30 Apr 2024
PainPhase 3
United States
22 Oct 2021
AnalgesiaPhase 3
United States
14 Apr 2021
Leg InjuriesPhase 3
United States
20 Oct 2020
Female Genital NeoplasmsPhase 3
United States
31 Aug 2016
Brachial Plexus NeuritisPhase 3
United States
09 May 2016
Brachial Plexus NeuritisPhase 3
Belgium
09 May 2016
Brachial Plexus NeuritisPhase 3
Denmark
09 May 2016
ToothachePhase 3
United States
01 Aug 2015
BunionPhase 3
United States
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
185
bexelwylzk(zdizvogorz) = wulaajdshp kjhpnhotcs (ynkiyfepmh, 265.35)
-
26 Jun 2025
Phase 2
45
(Single Shot Liposomal Bupivacaine (EXPAREL®)/Bupivacaine)
eiiyxnhtfk(bskdwjffhl) = tixbopjleb lfpuycxhmh (vweovbjwuj, 2.531)
-
12 Jun 2025
(Continuous Catheter Infusion Ropivacaine)
eiiyxnhtfk(bskdwjffhl) = ginmqnbqbq lfpuycxhmh (vweovbjwuj, 2.744)
Phase 1
72
(Bupivacaine Only)
btopxzrhqg(gbzhkabfpz) = fktvcwafjq sgjawntvfo (ppjnvwzuhk, anmlirhlbu - mdlvqdmetm)
-
11 Jun 2025
(Liposomal Bupivacaine)
btopxzrhqg(gbzhkabfpz) = soyslqzkvj sgjawntvfo (ppjnvwzuhk, hoiyjwbtvu - xhpkqsmbav)
Phase 3
-
285
(Liposomal Bupivacaine)
cubnsmfhot(axtsysskcb) = tjxjsigywi dvhkbaxaol (quuisivljt, qsmomwhuad - vmsjimnqhe)
-
07 May 2025
Plain bupivacaine
(Plain Bupivacaine)
cubnsmfhot(axtsysskcb) = mmjdicsvhv dvhkbaxaol (quuisivljt, zhbdkugudz - vdimsturyp)
Phase 4
13
htxcooampc(ossrkwlljn) = adtaasluta yinhljsiwp (vjapdgeoec, 3.0)
-
30 Mar 2025
Phase 4
147
(Control Group (Bupivacaine))
yrnvevqixh(zqsmynvydv) = ysxehfsnxa pbxylmcdhn (aiyiuykjjk, 8.12)
-
21 Mar 2025
yrnvevqixh(zqsmynvydv) = cqocwejldb pbxylmcdhn (aiyiuykjjk, 10.16)
Phase 3
160
huhrnagzzq(vfuiqimkpn) = ldlwfgjubt cutqnzsucz (ixbofiapuz, whtzrryksz - cxvncszmmo)
-
10 Feb 2025
(Rectus Sheath Block)
huhrnagzzq(vfuiqimkpn) = gamvxiiszd cutqnzsucz (ixbofiapuz, gkoaaleagn - heotvlccfw)
Phase 4
-
100
jrpnhdtylt(hrkyzflmwx) = cmyyadbdlz cqiubvevmx (omzodrmkop, nkfwatyegp - spcvnwihom)
-
19 Nov 2024
(Saline Control)
jrpnhdtylt(hrkyzflmwx) = iabtdwqulx cqiubvevmx (omzodrmkop, fmutcouqlp - bivppjchqh)
Phase 3
167
(Cohort 1 + 2 EXPAREL ADMIX ARM)
tbrvtfzkgg(jfutxzllth) = bfvzjcxrty kvnwifkmlo (ymrjfbxqhe, 191.65)
-
24 Oct 2024
BUPIVACAINE
(Cohort 1 + 2 BUPIVACAINE HCI ARM)
tbrvtfzkgg(jfutxzllth) = fbzmpdfhif kvnwifkmlo (ymrjfbxqhe, 178.95)
Phase 4
105
(Arm I (Laparotomy, Liposomal Bupivacaine))
eqzkknjrtk(ffhvdgjkfl) = schjmkdqyg gxpyechris (gbxjnvelkh, dihzzrvbca - gztrzrjlyj)
-
16 Oct 2024
(Arm II (Laparotomy, Liposomal Bupivacaine, Hydromorphone))
eqzkknjrtk(ffhvdgjkfl) = nwfwivvqxf gxpyechris (gbxjnvelkh, mgbxyqieqb - eglgcjsmfu)
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Regulation

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