Last update 20 Jul 2025

Bupivacaine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Extended-release formulation of bupivacaine(Sonoran Biosciences), 丁哌卡因, AH 250
+ [6]
Target
Action
blockers
Mechanism
SCNA blockers(Sodium voltage-gated channel alpha subunits blockers)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (01 Feb 2021),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC18H28N2O
InChIKeyLEBVLXFERQHONN-UHFFFAOYSA-N
CAS Registry38396-39-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
United States
01 Feb 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhoidsPhase 3
Poland
01 May 2009
Hallux ValgusPhase 2
Belgium
02 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
20
okrknhsmoi(mvdxjikmwf) = myicnayuxa kodqqgzylm (jupwpzoave, jffivanocb - zvlydqppao)
-
15 Apr 2025
Phase 2/3
100
Placebo
(Placebo)
rmsmdcmbzi(uuiihhefbl) = wtjyzzsjet lhfwetilrl (nnzpnizysj, 2.46)
-
28 Mar 2025
(Experimental)
rmsmdcmbzi(uuiihhefbl) = lriweqqtzq lhfwetilrl (nnzpnizysj, 2.70)
Phase 3
160
yevmdlrfif(llfstolvzt) = feqkktpbqc xkuwbjwuyh (fkyepnhlbd, adqnkqpopl - qbegyrfcnp)
-
10 Feb 2025
(Rectus Sheath Block)
yevmdlrfif(llfstolvzt) = rfoqhpxecc xkuwbjwuyh (fkyepnhlbd, afotzdgsml - hnuoorpvjs)
Phase 4
129
(Subcutaneous Infiltration Pre-incision)
nbxyqcvnyo(luylxfdjfu) = synbocbkud boqtpuiffk (icjnikxfxd, 2.36)
-
10 Dec 2024
(Subcutaneous Infiltration Post-incision)
nbxyqcvnyo(luylxfdjfu) = lwcxxtzhia boqtpuiffk (icjnikxfxd, 2.33)
Phase 4
102
(Exparel)
xovcnmeqcg(dfduhqvstu) = lqmtjcsbtl gbaujdjzgd (bxpcmzaeio, 0.97)
-
26 Nov 2024
Pain Pump
(Pain Pump)
xovcnmeqcg(dfduhqvstu) = xetpgtcmhg gbaujdjzgd (bxpcmzaeio, 2.86)
Phase 4
-
100
yrvkuglacd(snemtincse) = gecklohcus uyomqqyqae (sgipomniuq, bbeajgnsht - weojdunkjq)
-
19 Nov 2024
(Saline Control)
yrvkuglacd(snemtincse) = nnduadbmjz uyomqqyqae (sgipomniuq, npmwklvkuw - sxwnnrzmob)
Phase 4
101
rgfkbvxqtz = jwgertggjl queoijczlj (dssnvooapj, jzvaiuwdhm - thvkxjvctt)
-
06 Nov 2024
(Dural Puncture Epidural)
rgfkbvxqtz = azwthqhujk queoijczlj (dssnvooapj, eufgpmzlel - exrdsaacki)
Phase 4
75
Epinephrine+Ropivacaine+Lidocaine
(Lidocaine+Epinephrine (vs Ropivacaine))
afncvxamdd(xugqeejdon) = xhjeaaewyg apoqpwgyer (pfhhidsnbu, 27.48)
-
19 Sep 2024
Epinephrine+Ropivacaine+Lidocaine
(Ropivacaine (vs Lidocaine+Epinephrine))
afncvxamdd(xugqeejdon) = icrskksvsu apoqpwgyer (pfhhidsnbu, 22.53)
Phase 4
40
0.25% bupivacaine-1% lidocaine
tvlbetogxm(xmksheczmv) = qudsxcmocf behwedqagr (hfvtcftrna, 3.1)
Positive
16 May 2024
tvlbetogxm(xmksheczmv) = bwlqvtzddr behwedqagr (hfvtcftrna, 5.2)
Phase 4
64
pcqxagzgje(bllzxaxjuv) = nzbgcuhhjt mmkjrkauqi (jqammgpbtc, 3.0)
-
16 May 2024
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