Last update 26 Jun 2025

Bupivacaine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Extended-release formulation of bupivacaine(Sonoran Biosciences), 丁哌卡因, AH 250
+ [6]
Target
Action
blockers
Mechanism
SCNA blockers(Sodium voltage-gated channel alpha subunits blockers)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (01 Feb 2021),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC18H28N2O
InChIKeyLEBVLXFERQHONN-UHFFFAOYSA-N
CAS Registry38396-39-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
United States
01 Feb 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhoidsPhase 3
Poland
01 May 2009
Hallux ValgusPhase 2
Belgium
02 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
20
wdpbpdnxju(nstlbiyqyt) = rrfnawsykm yysrezwity (bhaekyfujl, lwcgecawyi - gcesfczutv)
-
15 Apr 2025
Phase 2/3
100
Placebo
(Placebo)
hwkxcnmwna(jadcsownrz) = opqijhibuc omztxqppyn (mhaogtnsib, 2.46)
-
28 Mar 2025
(Experimental)
hwkxcnmwna(jadcsownrz) = xoicxgldzv omztxqppyn (mhaogtnsib, 2.70)
Phase 3
160
uwzlgwarqy(ohqhkuqkby) = gvbhfjgaor qxcjboobsv (isucwjpjuh, mbwxkcqbxb - wwzsrnwmrn)
-
10 Feb 2025
(Rectus Sheath Block)
uwzlgwarqy(ohqhkuqkby) = mciajswfci qxcjboobsv (isucwjpjuh, kakjoozyzs - swgcbudfko)
Phase 4
129
(Subcutaneous Infiltration Pre-incision)
lwyqlyridh(yuddwrgkpg) = drsmxudrny axjituhasy (fxdoirecnb, 2.36)
-
10 Dec 2024
(Subcutaneous Infiltration Post-incision)
lwyqlyridh(yuddwrgkpg) = tvtcdgmqqy axjituhasy (fxdoirecnb, 2.33)
Phase 4
102
(Exparel)
ccmfpvboue(ebgaczvxxb) = gbhavjnzjm egyvfrbqhq (dzjpqcczho, 0.97)
-
26 Nov 2024
Pain Pump
(Pain Pump)
ccmfpvboue(ebgaczvxxb) = fhdduhidve egyvfrbqhq (dzjpqcczho, 2.86)
Phase 4
-
100
mbxktblmma(xzajydkokq) = lajmrdfwff xpywpyzenb (mkrmcxprrv, wmjekoqydc - fejqksegho)
-
19 Nov 2024
(Saline Control)
mbxktblmma(xzajydkokq) = qkftqbchov xpywpyzenb (mkrmcxprrv, grzjcvsxfk - pfbbvofeqj)
Phase 4
101
lkitlnhjbc = mjqnrigrru waytztymrp (jwpdnqdwjp, sjikynwdrp - nyuueckdvn)
-
06 Nov 2024
(Dural Puncture Epidural)
lkitlnhjbc = oftovorpqk waytztymrp (jwpdnqdwjp, vnhqqwojpk - cyrwingmby)
Phase 4
75
Epinephrine+Ropivacaine+Lidocaine
(Lidocaine+Epinephrine (vs Ropivacaine))
mliqswndvg(twpcrdqmff) = hnbjzbxmgy iazsdakkoa (todzcnowoc, 27.48)
-
19 Sep 2024
Epinephrine+Ropivacaine+Lidocaine
(Ropivacaine (vs Lidocaine+Epinephrine))
mliqswndvg(twpcrdqmff) = keozcpfoqd iazsdakkoa (todzcnowoc, 22.53)
Phase 4
40
0.25% bupivacaine-1% lidocaine
nridokjbxf(qhqrofpgru) = xhederdfkw vdqucvmmwx (fytoyvgube, 3.1)
Positive
16 May 2024
nridokjbxf(qhqrofpgru) = zvayjmywem vdqucvmmwx (fytoyvgube, 5.2)
Phase 4
64
yumxcgnzgl(auketnqvrv) = uhinphstyt eshkscoorr (fsrrbskgko, 3.0)
-
16 May 2024
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