Delving into the Latest Updates on Pegvorhyaluronidase alfa with Synapse

Overview

Basic Info

Drug Type

Enzyme

Synonyms

Pegvorhyaluronidase alfa (USAN/INN), pegvorhyaluronidase alpha, Pegylated hyaluronidase

+ [8]

Target

Hyaluronic acid

Action

modulators

Mechanism

Hyaluronic acid modulators

Therapeutic Areas

NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease+ [1]

Active Indication

Advanced Pancreatic AdenocarcinomaAdvanced Pancreatic Ductal AdenocarcinomaProstatic Cancer

Inactive Indication

Gallbladder adenocarcinomaLocally Advanced Malignant Solid NeoplasmLocally Advanced Pancreatic Adenocarcinoma+ [7]

Originator Organization

Halozyme Therapeutics, Inc.

Active Organization

Halozyme Therapeutics, Inc.

Inactive Organization

The University of California, San Francisco

License Organization

Nektar Therapeutics

Merck & Co., Inc.

Halozyme Therapeutics, Inc.

Drug Highest PhaseClinical

First Approval Date-

Regulation-

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Structure/Sequence

Sequence Code 136165

Source: *****

This study is the study of the combination of PEGPH20 and Pembrolizumab (MK-3475) for patients with previously treated Hyaluronan High (HA-high) metastatic pancreatic ductal adenocarcinoma. This study is an interventional, unblinded, open label study. Approximately 35 subjects will be enrolled. The trial will require approximately a total of 18 months, including 12 months for enrollment, with an additional 6 months for patient follow-up, data collection and study closure.
Each subject will participate in the trial from the time the subject signs the Informed Consent Form (ICF) through the final contact. After a screening phase of up to 21 days, eligible subjects will receive PEGPH20 beginning with Cycle 1 Day 1, on Days 1, 8 15 of every 3 week-cycles and pembrolizumab beginning on Cycle 1 Day 1 (2-4 hrs after PEGPH20), every 3-week-cycles.
Treatment with PEGPH20 and pembrolizumab will continue until progressive disease (PD), unacceptable adverse events (AEs), intercurrent illness that prevents further administration of treatment, investigator's decision to withdraw the subject, subject withdraws consent, pregnancy of the subject, noncompliance with trial treatment or procedure requirements, subject receives 35 treatments (approximately 24 months) of pembrolizumab, or administrative reasons requiring cessation of treatment. Subjects who discontinue for reasons other than PD will have post-treatment follow-up for disease status until PD, initiating a non-study cancer treatment, withdrawing consent, or becoming lost to follow-up. All subjects will be followed by telephone for overall survival (OS) until death, withdrawal of consent, or the end of the study.
After the end of treatment, each subject will be followed for 30 days for AE monitoring. Serious adverse events (SAE) and events of clinical interest (ECI) will be collected for 90 days after the end of treatment or for 30 days after the end of treatment if the subject initiates new anticancer therapy, whichever is earlier.

Start Date01 May 2019

Sponsor / Collaborator

Pancreatic Cancer Research Team

[+3]

100 Clinical Results associated with Pegvorhyaluronidase alfa

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100 Translational Medicine associated with Pegvorhyaluronidase alfa

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100 Patents (Medical) associated with Pegvorhyaluronidase alfa

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42

Literatures (Medical) associated with Pegvorhyaluronidase alfa

01 Sep 2024·BIOMEDICINE & PHARMACOTHERAPY

Hyaluronidase improves the efficacy of nab-paclitaxel after prolonged angiogenesis inhibition in preclinical models for esophagogastric cancer

Article

Author: Liu, Dajia ; Waasdorp, Cynthia ; Meijer, Sybren L ; Oyarce, Cesar ; Bootsma, Sanne ; Guo, Lihui ; Bijlsma, Maarten F ; van Laarhoven, Hanneke W M

BACKGROUND:

Long-term anti-angiogenesis leads to pruned vasculature, densely deposited extracellular matrix (ECM), and consequently reduced chemotherapy delivery in esophagogastric cancer (EGC). To address this issue, we evaluated the efficacy of adding a hyaluronidase or a NO-donor to the regimen of chemotherapy and anti-angiogenic drugs.

METHODS:

A patient-derived EGC xenograft model was developed. Grafted mice were randomly assigned to four experimental groups and one control group. The experimental groups received DC101, a murine angiogenesis inhibitor, and nab-paclitaxel (NPTX), with the addition of hyaluronidase (PEGPH20), or NO-donor (nitroglycerine, NTG), or their combination, respectively. We compared tumor growth during 17 days of treatment. We performed immunohistochemistry for ECM components hyaluronan (HA) and collagen, CD31 for endothelial cells, and γH2AX for DNA damage. The positively stained areas were quantified, and vessel diameters were measured using QuPath software.

RESULTS:

Prolonged DC101 treatment induced deposition of HA (p<0.01) and collagen (p<0.01). HA was effectively degraded by PEGPH20 (p<0.001), but not by NTG as expected. Both PEGPH20 (p<0.05) and NTG (p<0.01) dilated vessels collapsed in response to long-term DC101 treatment. However, only PEGPH20 (rather than NTG) was found to significantly inhibit tumor growth (p<0.05) in combination with NPTX and DC101.

CONCLUSIONS:

These findings suggest that the mechanical barrier of HA is the major reason responsible for the resistance developed during prolonged anti-angiogenesis in EGC. Incorporating PEGPH20 into the existing treatment regimen is promising to improve outcomes for patients with EGC.

01 Aug 2024·Molecular Metabolism

Limiting extracellular matrix expansion in diet-induced obese mice reduces cardiac insulin resistance and prevents myocardial remodelling

Article

Author: Hasib, Annie ; Wasserman, David H ; Kang, Li ; Musale, Vishal ; Banah, Ayman K ; Hennayake, Chandani K ; Lang, Chim C ; Murdoch, Colin E ; Dong, Bo

OBJECTIVE:

Obesity increases deposition of extracellular matrix (ECM) components of cardiac tissue. Since obesity aggregates with insulin resistance and heart disease, it is imperative to determine whether the increased ECM deposition contributes to this disease cluster. The hypotheses tested in this study were that in cardiac tissue of obese mice i) increased deposition of ECM components (collagens and hyaluronan) contributes to cardiac insulin resistance and that a reduction in these components improves cardiac insulin action and ii) reducing excess collagens and hyaluronan mitigates obesity-associated cardiac dysfunction.

METHODS:

Genetic and pharmacological approaches that manipulated collagen and hyaluronan contents were employed in obese C57BL/6 mice fed a high fat (HF) diet. Cardiac insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp and cardiac function was measured by pressure-volume loop analysis in vivo.

RESULTS:

We demonstrated a tight association between increased ECM deposition with cardiac insulin resistance. Increased collagen deposition by genetic deletion of matrix metalloproteinase 9 (MMP9) exacerbated cardiac insulin resistance and pirfenidone, a clinically available anti-fibrotic medication which inhibits collagen expression, improved cardiac insulin resistance in obese mice. Furthermore, decreased hyaluronan deposition by treatment with PEGylated human recombinant hyaluronidase PH20 (PEGPH20) improved cardiac insulin resistance in obese mice. These relationships corresponded to functional changes in the heart. Both PEGPH20 and pirfenidone treatment in obese mice ameliorated HF diet-induced abnormal myocardial remodelling.

CONCLUSION:

Our results provide important new insights into the role of ECM deposition in the pathogenesis of cardiac insulin resistance and associated dysfunction in obesity of distinct mouse models. These findings support the novel therapeutic potential of targeting early cardiac ECM abnormalities in the prevention and treatment of obesity-related cardiovascular complications.

01 May 2024·BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Characteristics of the Antitumor Effect of Doxorubicin and Pegylated Hyaluronidase on Models of Rat Brain Tumors

Article

Author: Kosyreva, A M ; Madonov, P G ; Alekseeva, A I ; Miroshnichenko, E A ; Nadeev, A P ; Arutyunyan, I V ; Kudelkina, V V ; Magsarzhav, Ts

Hyaluronidase increases tissue permeability and diffusion of the extracellular fluid by cleaving hyaluronan, the primary component of the extracellular matrix. Hyaluronidase pegylation (Hyal-PEG) decreases its clearance and enhances biodistribution. The pro- and anticancer activity of Hyal-PEG and a combination of Hyal-PEG with doxorubicin were studied in vitro (morphological analysis of rat glioblastoma 101.8 spheroids) and in vivo (by the survival time of rats after intracerebral transplantation of the tumor and morphological analysis). In the presence of doxorubicin and Hyal-PEG in the culture medium in vitro, spheroids lost their ability to adhere to the substrate and disintegrate into individual cells. Intracerebral transplantation of the tumor tissue with Hyal-PEG did not accelerate glioblastoma growth. The mean survival time for animals receiving transplantation of the tumor alone and in combination with Hyal-PEG was 13 and 20 days, respectively. In one rat with transplanted tumor and Hyal-PEG, this parameter increased by 53%. The survival time of rats receiving systemic therapy with doxorubicin and Hyal-PEG significantly increased (p=0.003). Antitumor effect of therapeutic doses of doxorubicin combined with Hyal-PEG was demonstrated on the model of rat glioblastoma 101.8 in vitro. Hyal-PEG inhibited adhesion of tumor cells, but did not cause their death. Transplantation of Hyal-PEG-treated tumor did not reduce animal survival time. Systemic administration of therapeutic doses of doxorubicin with Hyal-PEG increased survival time of rats with glioblastoma 101.8.

10

News (Medical) associated with Pegvorhyaluronidase alfa

08 Sep 2023

·www.pmlive.com

ICR study finds way to determine efficacy of experimental breast cancer drugs

Researchers at The Institute of Cancer Research (ICR), London, have discovered a way to use a simple, non-invasive MRI scan to determine whether an experimental approach to enhance treatment for breast cancer is effective. New research from the study, funded by Cancer Research UK, could help doctors visualise tumours and speed up the development of targeted therapies for breast cancer. If successful, these drugs could enhance the effectiveness of other drugs administered in combination. Common features of breast cancer include excessive connective tissue, which consists of cells and fibres that provide a scaffold, known as the extracellular matrix (ECM), where tumours can grow. Hyaluronic acid, which works by absorbing water, is naturally present inside the tumour ECM and causes cancer tumours to swell, making it challenging for drugs to penetrate, reach and destroy cancer cells. Researchers are able to use experimental drugs that target and degrade a chemical called hyaluronic acid to dissolve some of the dense ECM and improve drug delivery to tumours. However, when using experimental drugs targeting the chemical in this way, it can be difficult for researchers to identify the exact time when the acid has been degraded, and therefore, it is a challenge to determine the best time to administer other drugs. The researchers performed multi-parametric MRI scans on mice with breast tumours to track the efforts of PEGPH20, an investigational drug targeting hyaluronic acid, to gain measurements that provide additional information about the tissue being analysed. Study leader, Simon Robinson, professor, magnetic resonance imaging of cancer, ICR, London, said: "Diffusion-weighted MRI can be performed on conventional clinical MRI scanners. Our new research shows that we can use such scans to check if [experimental] drugs like PEGPH20 are working, helping guide treatment in a more targeted and non-invasive way." For example, after using diffusion-weighted imaging to understand how water molecules moved within tissue, the researchers found that a measurement of water’s ability to move or spread, called the apparent diffusion coefficient (ADC), was reduced by up to 38% following administration of PEGPH20. The results suggest that PEGPH20 could make breast cancer tissue more accessible to chemotherapy drugs and could potentially improve treatment outcomes. Upon further necessary testing, the researchers hope to improve the development of targeted therapies for breast cancer and potentially other tumours.

13 Apr 2022

·www.biospace.com

Halozyme Picks Up Antares’ Drug Delivery Tech for Nearly $1B

Halozyme Therapeutics announced that it is acquiring Antares Pharma for $960 million in cash. The news caused Antares stock to rocket 47% in premarket trading. Halozyme Therapeutics announced Wednesday morning that it is acquiring Antares Pharma for $960 million in cash. The news caused Antares stock to rocket 47% in premarket trading. “The addition of Antares with its best-in-class auto injector platform and specialty commercial business, augments Halozyme’s strategy, further strengthens our position as a leading drug delivery company and extends our strategy to include specialty products,” said Dr. Helen Torley, president and chief executive officer of Halozyme. Torley added, “The acquisition of Antares fits well with our previously discussed strategic priorities and provides substantial financial growth potential and disruptive solutions to significantly improve patient experiences and outcomes for emerging and established therapies. Halozyme is well-positioned to leverage Antares’ value proposition, driven by a strong balance sheet, established industry relationships and business development experience.” On March 24, Halozyme inked a global collaboration and license deal with Roche subsidiary Chugai Pharmaceuticals, giving Chugai access to Halozyme’s ENHANZE drug delivery technology recombinant human hyaluronidase PH20 enzyme (rHuPH20). The target was not disclosed. Under the deal, Chugai paid Halozyme $25 million up front with potential milestones of up to $160 million. Halozyme will also be eligible for royalties on sales of any commercialized products using the ENHANZE technology. ENHANZE removes traditional limitations on the volume of biologics that can be injected subcutaneously, allowing biologics that could only be dosed intravenously to be delivered subcutaneously. Halozyme has deals with several companies for its ENHANZE technology, including Roche , Baxalta , Pfizer , AbbVie, Eli Lilly , Bristol-Myers Squibb, Alexion , argenx, Horizon Therapeutics, ViiV Healthcare and now Chugai. Antares is a specialty pharmaceutical company that develops and commercializes drugs and technologies for targeted therapeutic areas using its advanced drug delivery systems. Most recently, on March 29, it announced the U.S. Food and Drug Administration granted final approval for Tlando (testosterone undecanoate), an oral drug for testosterone replacement therapy indicated for disorders linked to a deficiency or absence of endogenous testosterone or hypogonadism in adult males. The company’s products include Xyosted, a weekly auto-injector testosterone therapy, Tlando, Nocdurna, a sublingual tablet for the treatment of nocturia due to nocturnal polyuria in adults who wake up at least twice a night to urinate, and Sumatriptan, a generic of Imitrex (sumatriptan succinate) to treat acute migraine with or without aura, and acute cluster headaches in adults. Halozyme has a market value of approximately $5.7 billion. In 2019, the company restructured after the failure of a metastatic pancreatic cancer drug in Phase III. In November 2019, Torley said the company would discontinue clinical development of the drug, PEGPH20, as well as its entire oncology operation. It intended to focus entirely on its ENHANZE technology. It also markets a range of custom drug delivery devices. Of the acquisition, Robert F. Apple, president and chief executive office of Antares, stated, “We are pleased to have reached this agreement with Halozyme, as this transaction showcases the value of Antares’ highly complementary business, provides our shareholders with attractive and certain value, and brings together industry-leading expertise and drug delivery platforms to accelerate growth and create new opportunities. As we remain committed to continuing to serve our partners, I would like to thank our employees for their hard work and dedication to this mission. We look forward to working with the Halozyme team to complete the transaction and deliver best-in-class therapies and drug delivery solutions.”

Drug ApprovalAcquisitionLicense out/inPhase 3

05 Nov 2019

·www.bioportfolio.com

Theramex Buys Janssen’s Evorel Amid Ongoing HRT Shortages

Amid ongoing manufacturing issues with its own HRT patches, women’s health spin-out Theramex acquires global rights to Janssen’s Evorel patches... Related Stories Turkey’s Domestic Vaccine Production Drive Prompts New Partnerships Takeda Sheds Products, Employees To Stada In $660m Move Halozyme’s Spotlight Shifts To Enhanze Exclusively After PEGPH20 Fails In Phase III

Vaccine

100 Deals associated with Pegvorhyaluronidase alfa

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External Link

KEGG	Wiki	ATC	Drug Bank
D11201	-	-	DB14912

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Pancreatic Ductal Adenocarcinoma	Phase 3	United States	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Australia	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Belgium	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Brazil	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Canada	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Croatia	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Czechia	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Denmark	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	Estonia	Halozyme Therapeutics, Inc.	14 Mar 2016
Pancreatic Ductal Adenocarcinoma	Phase 3	France	Halozyme Therapeutics, Inc.	14 Mar 2016

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01839487 (HALO109-202, Pubmed \| J Transl Med)	Phase 2	Metastatic Pancreatic Ductal Adenocarcinoma	279	Pegvorhyaluronidase alfa plus nab-paclitaxel/gemcitabine	rvuypwtbov(dbuskduvfl) = flajktvdjd ebnjztpaxd (lptkcokvyy ) View more	Positive	21 Jan 2021
				Nab-paclitaxel/gemcitabine	rvuypwtbov(dbuskduvfl) = vumsrxqptb ebnjztpaxd (lptkcokvyy ) View more
NCT03979066 (NEOiPANC, CTgov)	Phase 2	Pancreatic Ductal Adenocarcinoma	1	Atezolizumab (Atezolizumab)	tiayludxnc(zejbvubwhc) = abclbmiqrn vqnoawkvgq (tvvesvtzlp, dkcgudagkl - aaytuhmphu) View more	-	23 Dec 2020
				Atezolizumab+PEGPH20 (Atezolizumab in Combination With PEGPH20)	tiayludxnc(zejbvubwhc) = nxpkhmhcxk vqnoawkvgq (tvvesvtzlp, fyzetbddcf - yfqwencyqg) View more
NCT02715804 (HALO 109-301, Pubmed \| J Urol) Manual	Phase 3	Pancreatic adenocarcinoma metastatic First line	492	Nab-Paclitaxel+Gemcitabine+Pegvorhyaluronidase Alfa	atqvhtsdvy(rdjdgfsigy) = jckpvzbyes qlkwbmpysm (hebpfrvzkg ) View more	Negative	20 Sep 2020
				Nab-Paclitaxel+Gemcitabine+Placebo	atqvhtsdvy(rdjdgfsigy) = cfwyhredak qlkwbmpysm (hebpfrvzkg ) View more
NCT01839487 (HALO 301 \| HALO 202 \| HALO109-202, CTgov)	Phase 2	Metastatic Pancreatic Cancer	279	Nab-paclitaxel+Gemcitabine (PAG: PEGPH20 + Nab-paclitaxel + Gemcitabine)	ramrlsxldn(kglniedagw) = ydhepgugho hlqmprmcgf (mmbssvngxe, eanszhpoxw - xqilatmqbu) View more	-	20 Jul 2020
				Nab-paclitaxel+Gemcitabine (AG: Nab-paclitaxel + Gemcitabine)	ramrlsxldn(kglniedagw) = xnotoskvhz hlqmprmcgf (mmbssvngxe, oqerttmaio - wnwrawuhhn) View more
NCT02715804 (HALO 109-301, CTgov)	Phase 3	Pancreatic Ductal Adenocarcinoma	492	Nab-paclitaxel+Gemcitabine+PEGPH20 (PAG: PEGPH20 + Nab-Paclitaxel + Gemcitabine)	bfyhrbzlav(onhwuejajp) = jizfusesrl yyqlwwlkrp (yaonrqribi, epgvhdwynr - qccybkblqi) View more	-	14 Jul 2020
				Placebo+Nab-paclitaxel+Gemcitabine (AG: Placebo + Nab-Paclitaxel + Gemcitabine)	bfyhrbzlav(onhwuejajp) = dcnlysybsj yyqlwwlkrp (yaonrqribi, vrefvizhry - ikjcjkttgx) View more
NCT03193190 \| NCT03281369 (ASCO 12020 \| ASCO 22020) Manual	Phase 1/2	Pancreatic Ductal Adenocarcinoma \| Stomach Cancer Second line	133	atezolizumab+PEGPH20 (M-PDAC)	dbhyevtogn(ongwraqesy) = bwtzkccise fikajkaabs (luxfmmdzvd ) View more	Negative	25 May 2020
				mFOLFOX6 or gemcitabine + nab-paclitaxel (M-PDAC)	dbhyevtogn(ongwraqesy) = mqojtamuci fikajkaabs (luxfmmdzvd ) View more
NCT01959139 (SWOG S1313 \| S1313, CTgov)	Phase 1/2	Pancreatic adenocarcinoma metastatic \| Metastatic Pancreatic Cancer	126	Leucovorin+Irinotecan+oxaliplatin+5-fluorouracil (Phase II: mFOLFIRINOX)	jmngokqrsw(rkohxtwywx) = hmkwgquzqu ewxkkyfhsx (rutbcujbov, hqqgfxchuu - pjyaypphpk) View more	-	12 Feb 2020
				Leucovorin+Irinotecan+oxaliplatin+PEGPH20+5-fluorouracil (Phase II: mFOLFIRINOX + PEGPH20)	jmngokqrsw(rkohxtwywx) = tfgucoxszi ewxkkyfhsx (rutbcujbov, xlcerwvavy - dqxkcowlvy) View more
NCT03267940 (CTgov)	Phase 1	Intrahepatic Cholangiocarcinoma \| Gallbladder adenocarcinoma \| Unresectable Intrahepatic Cholangiocarcinoma	85	GEM+CIS+PEGPH20 (Run-in Portion: PEGCISGEM)	ysdstpchno = tvmghebbhe ofjncrozlm (eosirhatdw, khqccpxonn - nkcurmdzhe) View more	-	07 Feb 2020
				GEM+atezolizumab+CIS+PEGPH20 (Run-in Portion: PEGCISGEMATEZO)	ysdstpchno = wlxlkdchxi ofjncrozlm (eosirhatdw, zpnmubwtcc - scvekqbljb) View more
NCT02715804 (HALO 109-301, ASCO_GI2020)	Phase 3	Metastatic Pancreatic Ductal Adenocarcinoma	494	PEGPH20 + nab-paclitaxel/gemcitabine	bfmafetbuk(jmhlmlzulu) = neutropenia (44% vs 47%), thrombocytopenia (21% vs 16%) and fatigue (16% vs 10%); G3+ rates were 6% vs 7% for TE events, 5% vs 2% for bleeding events and 13% vs 5% for musculoskeletal events. myyzmrzkoq (rzadtvmrkv ) View more	Negative	04 Feb 2020
				Placebo + nab-paclitaxel/gemcitabine
NCT02487277 (CTgov)	Phase 2	Pancreatic Ductal Adenocarcinoma	3	nab-paclitaxel+Gemcitabine+PEGPH20	bxgqhfyogy(rltbhazxti) = xqkvadgijr mlhkstanwa (tnnkvcbghy, fvctbmoofm - ejvzeuvpqz) View more	-	02 Jan 2020

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