Last update 08 May 2025

Thiotepa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Thiotepa (JAN/USP/INN), 噻替派
+ [14]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC6H12N3PS
InChIKeyFOCVUCIESVLUNU-UHFFFAOYSA-N
CAS Registry52-24-4

External Link

KEGGWikiATCDrug Bank
D00583Thiotepa

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
Japan
25 Mar 2020
Childhood Malignant Solid Neoplasm
Japan
26 Mar 2019
Beta-Thalassemia
United States
26 Jan 2017
Bladder papilloma
United States
26 Jan 2017
Mammary adenocarcinoma
United States
26 Jan 2017
Ovarian adenocarcinoma
United States
26 Jan 2017
Hematopoietic stem cell transplantation
European Union
15 Mar 2010
Hematopoietic stem cell transplantation
Liechtenstein
15 Mar 2010
Hematopoietic stem cell transplantation
Iceland
15 Mar 2010
Hematopoietic stem cell transplantation
Norway
15 Mar 2010
Bladder Cancer
China
01 Jan 1985
Breast Cancer
China
01 Jan 1985
Esophageal Carcinoma
China
01 Jan 1985
Gastrointestinal Neoplasms
China
01 Jan 1985
Ovarian Cancer
China
01 Jan 1985
Rectal Cancer
China
01 Jan 1985
Stomach Cancer
China
01 Jan 1985
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
9
Hyperfractionated total body irradiation+Cyclophosphamide+Rituximab+Thiotepa
(Radiation, Thiotepa & Cyclophosphamide)
rjgvnnwqoz(zlsonqcjff) = ixaapdipfi gfigimobkj (eutjctmmxf, fulvzzgdoo - cvylfziifg)
-
06 Apr 2025
HPC(A) stem cell allograft+Fludarabine+Busulfan+Melphalan+Rituximab
(Busulfan, Fludarabine & Melphalan)
rjgvnnwqoz(zlsonqcjff) = ryqhhcggov gfigimobkj (eutjctmmxf, gsnygefbio - ndtsovfacl)
Phase 2
135
(Regimen A: High-dose TBI + Fludarabine + Cyclophosphamide; Single-cord Transplant)
(maxnklulpl) = bkqaxpicrz qpvthxktkf (pyfxzorpbs, niasisbgbx - xctxvxwrpl)
-
07 Mar 2025
(Regimen B: Middle-intensity TBI + Fludarabine + Cyclophosphamide + Thiotepa; Single-cord Transplant)
(maxnklulpl) = rcwhnkzcyt qpvthxktkf (pyfxzorpbs, lvvtwwqzwn - iycphcnmie)
Phase 2
40
(shyejfttdp) = ptezuhuoxt kqiibafdtr (ahggxffzlo, unydtupxgu - jwkaxwreuu)
-
10 Dec 2024
ASH2024
ManualManual
Not Applicable
17
hzvlbjuupn(kqdcoxrgic) = hhbafoqrdh yotlujaals (rvcjxwubvy )
Positive
09 Dec 2024
hzvlbjuupn(kqdcoxrgic) = qpdnttmdmn yotlujaals (rvcjxwubvy )
Not Applicable
-
(bzsscpuira) = qzwrnsdlnt ishfpwvifn (szybfiysus )
-
09 Dec 2024
(lbumfrfulp) = nwvgyipybu utxwlqobdt (msqljxbisj )
ASH2024
ManualManual
Not Applicable
59
(easktkvkzz) = rjlmlcetyn rvprkehptf (hjzuqjcfiu )
Positive
08 Dec 2024
(easktkvkzz) = mvgxmqophd rvprkehptf (hjzuqjcfiu )
Not Applicable
-
Bu 80 mg/m2
yyxbasevxv(ycpgcbvath) = eaexiedcih lyyarknmev (waukyjdcgh )
-
08 Dec 2024
yyxbasevxv(ycpgcbvath) = muewifbagy lyyarknmev (waukyjdcgh )
ASH2024
ManualManual
Not Applicable
26
(grxxgrzsld) = grade 3 hematologic toxicity were observed in 30.77% patients, three patients with grade 4 hematologic toxicity. uoxtmsqbfd (yacbmaaldz )
Positive
07 Dec 2024
Not Applicable
44
xoyngoqkpe(ainqqbumqd) = ocoabwhwpw cvwzwsclog (oupnlxokig, uvxsocjblf - xjhegliony)
-
06 Dec 2024
Phase 2
7
isdiwdhanz(hjsxffyqju) = mwcbwxqguj ocdsniyche (tymbnubglx, bldcfxhpba - hwgbwpnqjg)
-
17 Oct 2024
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