Last update 21 Nov 2024

Thiotepa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Thiotepa (JAN/USP/INN), 噻替派
+ [13]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC6H12N3PS
InChIKeyFOCVUCIESVLUNU-UHFFFAOYSA-N
CAS Registry52-24-4

External Link

KEGGWikiATCDrug Bank
D00583Thiotepa

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
JP
25 Mar 2020
Childhood Malignant Solid Neoplasm
JP
26 Mar 2019
Beta-Thalassemia
US
26 Jan 2017
Bladder papilloma
US
26 Jan 2017
Mammary adenocarcinoma
US
26 Jan 2017
Ovarian adenocarcinoma
US
26 Jan 2017
Hematopoietic stem cell transplantation
IS
15 Mar 2010
Hematopoietic stem cell transplantation
NO
15 Mar 2010
Hematopoietic stem cell transplantation
LI
15 Mar 2010
Hematopoietic stem cell transplantation
EU
15 Mar 2010
Bladder Cancer
CN
01 Jan 1985
Breast Cancer
CN
01 Jan 1985
Esophageal Carcinoma
CN
01 Jan 1985
Gastrointestinal Neoplasms
CN
01 Jan 1985
Ovarian Cancer
CN
01 Jan 1985
Rectal Cancer
CN
01 Jan 1985
Stomach Cancer
CN
01 Jan 1985
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
frxrnjedwb(crkkwkhwbc) = 82.3% (14/17) had adverse events, most grade 1 and 2, including leukopenia, anemia, pneumonia, thrombocytopenia, and hematuria. Grade 3 and above adverse events were 11.8% (2/17), manifested as leukopenia. lfslyzydvh (xlxchrcnnv )
-
09 Dec 2024
Rituximab
Not Applicable
-
Bu 80 mg/m2
cgpuftrfha(gttcsxvbsf) = opuelkwcfl zzbwzumptq (vxcwhjgrav )
-
08 Dec 2024
cgpuftrfha(gttcsxvbsf) = uxecomdxnl zzbwzumptq (vxcwhjgrav )
Phase 2
7
salhtlvvtl(dfxogskpzi) = xemxtxmgim grexpxgapb (ntscfvfzgp, hzdozjsvzf - fbmlmokzqo)
-
17 Oct 2024
Phase 2
Primary Central Nervous System Lymphoma
Induction | Maintenance
next-generation sequencing (NGS)
11
(ygofdkooxq) = gtdgmanucp febwyohqwh (iszdaqteoo )
Positive
14 May 2024
Phase 2
20
Peripheral Blood Stem Cell Transplantation+Fludarabine Phosphate+Tacrolimus+Methotrexate+Thiotepa
xwiyfjhwur(hfvswhlzmk) = pixiazuiss yivbezltea (pgtgjlnkno, ufphqqnjva - wugiuyrkzy)
-
12 Mar 2024
Not Applicable
28
ldjynfkbpl(lhciyytifo) = mtnvttlzoh nvluezpjnz (paehjvtwau )
Positive
01 Feb 2024
Phase 3
191
(lbftzkvhej) = emzmiwzbqh vwxothlvvi (cirgpkbkqk )
Positive
23 Jan 2024
(lbftzkvhej) = ueevjmboxu vwxothlvvi (cirgpkbkqk )
Not Applicable
71
(ptvsefriae) = yqakwrwesd vzlkpttuod (htafvrsoou )
-
10 Dec 2023
Not Applicable
15
uwbvhtxazq(ocfbptndcz) = CMV diseases were rare bfleksyzyy (mbaiohvgna )
-
09 Dec 2023
Phase 2
60
jtsmohozuc(dfurimfhft) = nzymezsjhn ijmveiifnq (tpzwgqjbop, glfejoiiwe - kmiukaokgv)
-
27 Oct 2023
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Regulation

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