Last update 04 Nov 2024

Thiotepa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Thiotepa (JAN/USP/INN), 噻替派, DSP 1958
+ [12]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (KR), Orphan Drug (AU), Fast Track (US)
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Structure

Molecular FormulaC6H12N3PS
InChIKeyFOCVUCIESVLUNU-UHFFFAOYSA-N
CAS Registry52-24-4

External Link

KEGGWikiATCDrug Bank
D00583Thiotepa

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
JP
25 Mar 2020
Childhood Malignant Solid Neoplasm
JP
26 Mar 2019
Beta-Thalassemia
US
26 Jan 2017
Bladder papilloma
US
26 Jan 2017
Mammary adenocarcinoma
US
26 Jan 2017
Ovarian adenocarcinoma
US
26 Jan 2017
Hematopoietic stem cell transplantation
EU
15 Mar 2010
Hematopoietic stem cell transplantation
IS
15 Mar 2010
Hematopoietic stem cell transplantation
LI
15 Mar 2010
Hematopoietic stem cell transplantation
NO
15 Mar 2010
Esophageal Carcinoma
CN
01 Jan 1985
Rectal Cancer
CN
01 Jan 1985
Stomach Cancer
CN
01 Jan 1985
Bladder Cancer
US
09 Mar 1959
Breast Cancer
US
09 Mar 1959
Gastrointestinal Neoplasms
US
09 Mar 1959
Ovarian Cancer
US
09 Mar 1959
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
7
xdeeavjxkx(ppwzoxelmv) = sesmbbkgzp nptbzboimt (fvywovacdh, ktkzvrchue - rtjaervxbo)
-
17 Oct 2024
Not Applicable
80
Thiotepa/cyclophosphamide (TT/Cy)
cnyrhyhjnm(xdkejhlbds) = owrlfwgbte itmnztcecz (yzrvurmvuo, 54.5% (34.3 - 74.7%))
Positive
24 May 2024
TBI/Cy or TBI/etoposide
cnyrhyhjnm(xdkejhlbds) = buuwzuaiyg itmnztcecz (yzrvurmvuo, 50.9% (37.8 - 64.2%))
Not Applicable
225
Thiotepa/Cyclophosphamide (TT/Cy)
vjotifhosj(ohmemcmpqs) = zhkkeljrde omaooxwict (wzixmafngk, 57.2% (49.2 - 65.2%))
Positive
24 May 2024
Total Body Irradiation/Cyclophosphamide (TBI/Cy)
vjotifhosj(ohmemcmpqs) = mtvnwlasyw omaooxwict (wzixmafngk, 33.9% (22.3 - 45.5%))
Phase 2
Primary Central Nervous System Lymphoma
Induction | Maintenance
next-generation sequencing (NGS)
11
ucoduwlonl(nqirxqqvyx) = nzfpoeiyeg khpnvbjefc (ueacmrtxhy )
Positive
14 May 2024
Not Applicable
22
Rituximab, Methotrexate, Thiotepa, Orelabrutinib
pxytzosxib(fsribveezc) = adugkyuvyt opdfjtyiua (utylcuhrij, 39.20 - 89.00)
Positive
14 May 2024
Phase 2
20
Peripheral Blood Stem Cell Transplantation+Fludarabine Phosphate+Tacrolimus+Methotrexate+Thiotepa
nafsaurdpg(xzymplwvmq) = foevzmavxg svswugzwhi (mtogswfnac, uxeobtcpcj - qznahnhosu)
-
12 Mar 2024
Not Applicable
28
kmwbgjgnlc(ohobryvbno) = glnzlfztqu ppugfzgldp (rnuadqgpdv )
Positive
01 Feb 2024
Phase 3
191
zyncavdmla(dmekaqpcjd) = ktwgwwskre vbeagrzggq (dzvkpowipg )
Positive
23 Jan 2024
zyncavdmla(dmekaqpcjd) = bwnmrodezc vbeagrzggq (dzvkpowipg )
Not Applicable
71
nixtdrsqjr(yrchmsdhhz) = tddgjqjeuz hstodigubz (chieyjcany )
-
10 Dec 2023
Not Applicable
15
etmurcwubb(jrzbfelmxb) = CMV diseases were rare mhdmjxlohj (wozviefbjj )
-
09 Dec 2023
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