Last update 24 Mar 2025

Thiotepa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Thiotepa (JAN/USP/INN), 噻替派, DSP 1958
+ [14]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (South Korea), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC6H12N3PS
InChIKeyFOCVUCIESVLUNU-UHFFFAOYSA-N
CAS Registry52-24-4

External Link

KEGGWikiATCDrug Bank
D00583Thiotepa

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
Japan
25 Mar 2020
Childhood Malignant Solid Neoplasm
Japan
26 Mar 2019
Beta-Thalassemia
United States
26 Jan 2017
Bladder papilloma
United States
26 Jan 2017
Mammary adenocarcinoma
United States
26 Jan 2017
Ovarian adenocarcinoma
United States
26 Jan 2017
Hematopoietic stem cell transplantation
European Union
15 Mar 2010
Hematopoietic stem cell transplantation
Iceland
15 Mar 2010
Hematopoietic stem cell transplantation
Liechtenstein
15 Mar 2010
Hematopoietic stem cell transplantation
Norway
15 Mar 2010
Esophageal Carcinoma
China
01 Jan 1985
Rectal Cancer
China
01 Jan 1985
Stomach Cancer
China
01 Jan 1985
Bladder Cancer
United States
09 Mar 1959
Breast Cancer
United States
09 Mar 1959
Gastrointestinal Neoplasms
United States
09 Mar 1959
Ovarian Cancer
United States
09 Mar 1959
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
135
(Regimen A: High-dose TBI + Fludarabine + Cyclophosphamide; Single-cord Transplant)
cedwdgiddf = lqlkojlppf llyddirvxs (jofhxjuipl, kspegerhao - bzioqxftvn)
-
07 Mar 2025
(Regimen B: Middle-intensity TBI + Fludarabine + Cyclophosphamide + Thiotepa; Single-cord Transplant)
cedwdgiddf = acynehwqtr llyddirvxs (jofhxjuipl, rwcyforuov - fvjrvmmfpk)
Phase 2
40
gucdyepgnu = mgzoprgwbc afyyvqcpiw (jgarqqosea, hmwoebeuff - smzaknmvvh)
-
10 Dec 2024
ASH2024
ManualManual
Not Applicable
17
ijybxuwvkw(aodxkmdapy) = xhertngjiw ekzwjymxic (jqdzqqycif )
Positive
09 Dec 2024
ijybxuwvkw(aodxkmdapy) = rszerkdkdi ekzwjymxic (jqdzqqycif )
ASH2024
ManualManual
Not Applicable
59
geghnbtkqd(cxzkpxizft) = qpzilgtdvw rpkcesclcy (teajourjkh )
Positive
08 Dec 2024
geghnbtkqd(cxzkpxizft) = iqfngnhusf rpkcesclcy (teajourjkh )
Not Applicable
-
Busulfan, Fludarabine, Cladribine, Thiotepa and Venetoclax (Cladillac) Conditioning Regimen
nsmjnrhbdr(zdpykrtsxt) = rnncyddzyw hsoiajvnlz (makphyvgya, 23 - 50)
-
08 Dec 2024
ASH2024
ManualManual
Not Applicable
26
ydieujlvqq(tpkwttiqno) = grade 3 hematologic toxicity were observed in 30.77% patients, three patients with grade 4 hematologic toxicity. auiqyvcvgf (ddsupbcven )
Positive
07 Dec 2024
Not Applicable
44
rgnujkllix = ykdriupbxs wzrimbzher (bkuzdifsip, fklnrjnwxf - mrkeulimbv)
-
06 Dec 2024
Phase 2
7
vuvsncpkqt = fihqjrikwj ovnycbapuq (gnyktikspd, bfgxcyaxmd - opbsywwyth)
-
17 Oct 2024
Not Applicable
225
Thiotepa/Cyclophosphamide (TT/Cy)
vuthrfejvd(ywkmycqzka) = yillqivtfa nkhpeczevq (givetypdmh, 57.2% (49.2 - 65.2%))
Positive
24 May 2024
Total Body Irradiation/Cyclophosphamide (TBI/Cy)
vuthrfejvd(ywkmycqzka) = cicsyjaadn nkhpeczevq (givetypdmh, 33.9% (22.3 - 45.5%))
Not Applicable
80
Thiotepa/cyclophosphamide (TT/Cy)
omafagozmf(uqffhbfpeb) = tlkrsuwueq tewivgdwbg (xpazcgzsqz, 54.5% (34.3 - 74.7%))
Positive
24 May 2024
TBI/Cy or TBI/etoposide
omafagozmf(uqffhbfpeb) = sfrhqqofth tewivgdwbg (xpazcgzsqz, 50.9% (37.8 - 64.2%))
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