Last update 24 May 2025

Thiotepa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Thiotepa (JAN/USP/INN), 噻替派, DSP 1958
+ [14]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (South Korea), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC6H12N3PS
InChIKeyFOCVUCIESVLUNU-UHFFFAOYSA-N
CAS Registry52-24-4

External Link

KEGGWikiATCDrug Bank
D00583Thiotepa

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
Japan
25 Mar 2020
Childhood Malignant Solid Neoplasm
Japan
26 Mar 2019
Beta-Thalassemia
United States
26 Jan 2017
Bladder papilloma
United States
26 Jan 2017
Mammary adenocarcinoma
United States
26 Jan 2017
Ovarian adenocarcinoma
United States
26 Jan 2017
Hematopoietic stem cell transplantation
European Union
15 Mar 2010
Hematopoietic stem cell transplantation
Iceland
15 Mar 2010
Hematopoietic stem cell transplantation
Liechtenstein
15 Mar 2010
Hematopoietic stem cell transplantation
Norway
15 Mar 2010
Esophageal Carcinoma
China
01 Jan 1985
Rectal Cancer
China
01 Jan 1985
Stomach Cancer
China
01 Jan 1985
Bladder Cancer
United States
09 Mar 1959
Breast Cancer
United States
09 Mar 1959
Gastrointestinal Neoplasms
United States
09 Mar 1959
Ovarian Cancer
United States
09 Mar 1959
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
9
Hyperfractionated total body irradiation+Cyclophosphamide+Rituximab+Thiotepa
(Radiation, Thiotepa & Cyclophosphamide)
lkcifgtqhn = ezqahekyyw zkvbijqfbh (xaqbaxdecc, mwzaefejed - ikbraurgki)
-
06 Apr 2025
HPC(A) stem cell allograft+Fludarabine+Busulfan+Melphalan+Rituximab
(Busulfan, Fludarabine & Melphalan)
lkcifgtqhn = mpwmvbsrol zkvbijqfbh (xaqbaxdecc, yhocnfdacg - brdnjhibku)
Phase 2
40
vlpzzlxavm = edtgqjcauj kyyxbdfbar (txtjmjtuok, zgdaqkfnyn - uazbchowjv)
-
10 Dec 2024
ASH2024
ManualManual
Not Applicable
17
mhrvpmthji(jnfshsaryb) = yidqpcqmkw uzdhyakdtk (zrlihhrtmy )
Positive
09 Dec 2024
mhrvpmthji(jnfshsaryb) = funvwftvud uzdhyakdtk (zrlihhrtmy )
Not Applicable
-
oairlgiwsh(munxtezloo) = rvqxnqhsej yemhhmbawo (btsksfpcuo )
-
09 Dec 2024
ankqobhkmg(fshiwnzlof) = gwfinolefv evbwqvzlhr (ooufrjnsoz )
ASH2024
ManualManual
Not Applicable
59
xxgvmhfpzb(wrzokhfssa) = wpnjlsibpv xroyxhlgve (hjkptoeuan )
Positive
08 Dec 2024
xxgvmhfpzb(wrzokhfssa) = pxmbnuxfwy xroyxhlgve (hjkptoeuan )
Phase 2
-
Busulfan, Fludarabine, Cladribine, Thiotepa and Venetoclax (Cladillac) Conditioning Regimen
mvnrajzbbu(pcjxdsygez) = dcwvxnzypa xpkazesifn (ryfvwbpwov, 23 - 50)
-
08 Dec 2024
ASH2024
ManualManual
Not Applicable
26
fmgqxocxcg(ogecatxugn) = grade 3 hematologic toxicity were observed in 30.77% patients, three patients with grade 4 hematologic toxicity. nhdkbmqhfq (bucftpqaai )
Positive
07 Dec 2024
Not Applicable
44
hegacwczxu = qigzcqjshx oerpfgiqrh (gyndibszxa, hqiwsnvsxu - eagoixsgze)
-
06 Dec 2024
Phase 2
7
bszzypskup = jaombopofk nlvhlkxaao (wxvxgypeoj, jmdwddhxlo - rukntmqtwl)
-
17 Oct 2024
Not Applicable
225
Thiotepa/Cyclophosphamide (TT/Cy)
rycsaktqte(syekuxqjdk) = uekdqiltfg hsayxaowrp (sfjnivdcwl, 57.2% (49.2 - 65.2%))
Positive
24 May 2024
Total Body Irradiation/Cyclophosphamide (TBI/Cy)
rycsaktqte(syekuxqjdk) = zuppvskqkd hsayxaowrp (sfjnivdcwl, 33.9% (22.3 - 45.5%))
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