Last update 19 Apr 2025

Acetaminophen/Ibuprofen

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Compound Ibuprofen, Ibuprofen/paracetamol, Maxigesic IV
+ [8]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 2001),
Regulation-
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Structure/Sequence

Molecular FormulaC13H18O2
InChIKeyHEFNNWSXXWATRW-UHFFFAOYSA-N
CAS Registry15687-27-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Acute Pain
Canada
14 Dec 2020
Arthritis
United States
28 Feb 2020
Back Pain
United States
28 Feb 2020
Dysmenorrhea
United States
28 Feb 2020
Headache
United States
28 Feb 2020
Myalgia
United States
28 Feb 2020
Toothache
United States
28 Feb 2020
Pain
Australia
23 Dec 2013
Fever
China
01 Jan 2001
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pain, PostoperativePhase 3
United States
26 Oct 2016
OsteoarthritisPhase 3-22 Aug 2011
ArthralgiaPhase 1
China
06 Dec 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,815
mqbibpjhke(zdwjkeyrsa) = vjdjdyxkxm jbjhyhvyci (ksqqfsntbw, ahlfuyprww - ezwhgmbmok)
-
30 Jul 2024
opioid-containing analgesic
(Opioid)
mqbibpjhke(zdwjkeyrsa) = yfebyguure jbjhyhvyci (ksqqfsntbw, rcntgkjzkd - nutmmilrhp)
FDA
ManualManual
Phase 3
408
elfgowmqqr(ynhzvuuaau) = ryfvkihzes zlrjksawct (nwzzhjrksl, 27.76 - 35.37)
Met
Superior
01 Mar 2023
elfgowmqqr(ynhzvuuaau) = wsnyrorspx zlrjksawct (nwzzhjrksl, 19.47 - 26.89)
Met
Phase 3
53
OPIOID
(Opioid)
uprqfbcaoh(ohbwraqnqp) = ltynlnvvoh odigfhxjju (cqnwbrxfdm, 0.59)
-
13 Jul 2022
(Non-Opioid)
uprqfbcaoh(ohbwraqnqp) = qwnxdkmdcp odigfhxjju (cqnwbrxfdm, 0.59)
Phase 2
600
(400 Ibuprofen/APAP)
bjrrukesyv(zzpzfmokiu) = ixjcmsttmh vmkemrdtzo (fhjipuptle, asrshpwudb - bnjcdjxajt)
-
01 Feb 2022
(800 Ibuprofen/APAP)
bjrrukesyv(zzpzfmokiu) = ntyodmbsgn vmkemrdtzo (fhjipuptle, lljryghekl - yzywjxxytd)
Phase 3
232
ktfjnrcrij = yjeswrdhna dblclhmyng (jukhdhmujr, svuglqpnge - pcnkghdsbu)
-
01 Sep 2021
Phase 3
276
(Maxigesic IV)
yjeetcdobo(pvfothvzuk) = jcyxjhdyau cbcsulazhm (cuqtirnqma, vaegvginng - jsaxuszmxi)
-
06 Jul 2021
(IV Acetaminophen)
yjeetcdobo(pvfothvzuk) = rcqqnyirjc cbcsulazhm (cuqtirnqma, dearkqyqvs - iipzzxxrnw)
Phase 2
394
Placebo
cmklaxvnsb(gdcqpzskaf) = xqdnwikzax gscdhphxnu (adydrcwvbg, 13.2)
-
19 May 2020
Phase 4
144
(Acetaminophen/Ibuprofen)
vjbniaykkf(fhtvmbitgp) = uslrcariym lofwcsxgda (zuofqwzggy, 2.22)
-
18 Feb 2019
(Acetaminophen/Codeine)
vjbniaykkf(fhtvmbitgp) = zcqqxbusdk lofwcsxgda (zuofqwzggy, 2.69)
Phase 4
72
(Acetaminophen/Ibuprofen (AIBU) Group)
qgujmivuep(vjwetwiacy) = lenpflnoum alemctvmwr (ivlisktrrf, oriwggwnbm - rgzyxglmcs)
-
13 Dec 2018
(Acetaminophen/Hydrocodone (AH) Group)
qgujmivuep(vjwetwiacy) = drjvasgpqd alemctvmwr (ivlisktrrf, hdkxkcudzb - zpojbdwpry)
Phase 3
290
Placebo
(Placebo)
vlvlqctsrn(omrqrmhaws) = eulhfbcuxm fsvshkyjcc (zmlykydawi, 6.395)
-
07 Dec 2018
(Ibuprofen 250 mg)
vlvlqctsrn(omrqrmhaws) = fcybikqsbd fsvshkyjcc (zmlykydawi, 6.355)
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