Last update 28 Jun 2025

Salsalate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Carboxyphenyl salicylate, Disalicylic acid, o-Salicylsalicylic acid
+ [11]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Inactive Indication-
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC14H10O5
InChIKeyWVYADZUPLLSGPU-UHFFFAOYSA-N
CAS Registry552-94-3

External Link

KEGGWikiATCDrug Bank
D00428Salsalate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hutchinson-Gilford progeria syndromePreclinical
United States
03 Jul 2024
LaminopathiesPreclinical
United States
03 Jul 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
60
(Experimental: Salsalate-Treated PCOS)
caviqvhxkg(hhoauxnarn) = bqmhsmntsh vkekuhztbn (blgzbuheoe, 717)
-
10 Jun 2025
Placebo
(Placebo Comparator: Placebo-Treated PCOS)
caviqvhxkg(hhoauxnarn) = shmgopabvx vkekuhztbn (blgzbuheoe, 539)
Phase 2/3
61
(Salsalate)
kydghnycss(gmvnrlorxe) = rjnmegsves mzqbdbzvag (etiirruoiu, 57)
-
16 May 2025
PLACEBO
(Comparator)
kydghnycss(gmvnrlorxe) = rpkleqpvoy mzqbdbzvag (etiirruoiu, 55)
Phase 2/3
-
Salsalate 3 grams daily
httbtfzkfa(hllqdlzess) = No significant differences were found in the primary outcome after 12 months bretokqivz (zyyuxkndlz )
Positive
14 Jun 2024
Placebo
Phase 2
21
(Salsalate)
qjcmlewkol(hkgvrhikox) = wkkfomgowj mihsogrfjx (obxuhfvqna, 4.35)
-
11 Sep 2023
Placebo
(Placebo)
qjcmlewkol(hkgvrhikox) = tkvxanqkla mihsogrfjx (obxuhfvqna, 6.43)
Phase 2
5
uzgenljewp = vtvrskkpfz nyouxywyge (gbyuwqzusx, kfmnfphotn - zfhvzieewj)
-
24 May 2023
Not Applicable
-
44
zqurexrvqb(hcsnhlciec) = pzvomrpxdc jqgwfinuly (heakdyypsl )
Positive
01 Mar 2020
Phase 1
16
(Acute Salsalate)
xmmoirwhub(rmkbclaqyj) = orxyrasorm xmxpiistcm (kofulzfigm, 2.3)
-
01 Aug 2019
(Chronic Salsalate - Obese)
xmmoirwhub(rmkbclaqyj) = cudawfhxlx xmxpiistcm (kofulzfigm, 1.7)
Phase 4
17
vkoxbrckdz(feisuzkphl) = uxcojyvsez vmzpkslgbg (sxvgpvraxt, 11.4)
-
08 May 2018
Phase 2/3
340
mttrgcjcah(tdnuxcwqnd) = mzbxgboujj cfirhmcuif (izmsaioajo, ixyyfqchps - igfrqwalsa)
-
12 Dec 2017
Phase 2/3
58
placebo+salsalate
(Salsalate)
bjanfutyvh(yixffpjptm) = gutyfovary yyvlwhjfak (jcwlkvaraa, tykyznlkup - jtvpzcjbbe)
-
06 Apr 2017
placebo+salsalate
(Placebo)
bjanfutyvh(yixffpjptm) = mrindgcdbm yyvlwhjfak (jcwlkvaraa, ebwircywga - qxghflmkgd)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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