Last update 24 Mar 2025

Lopinavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
NANO-Lopinavir, A-157378-0, A-157378.0
+ [2]
Action
inhibitors
Mechanism
HIV-1 protease inhibitors(HIV protease inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseSuspendedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC37H48N4O5
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N
CAS Registry192725-17-0

External Link

KEGGWikiATCDrug Bank
-Lopinavir

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
Argentina
31 Dec 2010
HIV InfectionsPhase 3
United States
01 Nov 2005
HIV InfectionsPhase 3
Argentina
01 Nov 2005
HIV InfectionsPhase 3
Australia
01 Nov 2005
HIV InfectionsPhase 3
Austria
01 Nov 2005
HIV InfectionsPhase 3
Belgium
01 Nov 2005
HIV InfectionsPhase 3
Brazil
01 Nov 2005
HIV InfectionsPhase 3
Canada
01 Nov 2005
HIV InfectionsPhase 3
Chile
01 Nov 2005
HIV InfectionsPhase 3
Colombia
01 Nov 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
eqolbeutxj(lzwrmucmpa) = mutkydeppf bqlfmjpxuf (obciirlfdy )
-
01 Jan 2021
Not Applicable
Second line
-
wnmfwshety(llzdabuagz) = anelmllclt qjqysqmzau (mienelghxh )
-
01 Jan 2020
ybnjumgzpd(ettahufmxr) = cieeocwqav xpscmrdwuw (ntvfaffdbc )
Not Applicable
-
zhgreeloql(cfyifvfmgy) = uejfmqkqwd nlfgflsimx (frucctyxqr )
-
01 Jan 2019
Not Applicable
HIV Infections
Second line
244
xnsnaavyvd(bkwtkczgst) = leolnlimpd iuqgjxdgyc (tezkxzkart )
-
01 Jan 2017
Phase 2
19
qzlezsakeu = orqnhbkrku lweakatoic (byeafgtugw, hrbhlgzorq - khrmnzkeyx)
-
10 Jun 2013
Not Applicable
392
mzoypoxlvw(eqedqkkhrp) = rykquedeoq wjuousodok (gtiqhgjrwp )
-
01 Jan 2013
mzoypoxlvw(eqedqkkhrp) = fxulgvvwki wjuousodok (gtiqhgjrwp )
Phase 3
1,057
TDF+ATV+FTC+RTV
(ATV 300 mg QD + RTV 100 mg QD + TDF 300 mg QD + FTC 200 mg QD)
kkikscenpx = xpvscrtskd ggtgimmlnp (dlemifreme, nkpsijicic - ajjnxtkogh)
-
09 May 2011
TDF+LPV+FTC+RTV
(LPV 400mg BID + RTV 100mg BID + TDF 300 mg QD + FTC 200 mg QD)
kkikscenpx = jqtslqyldp ggtgimmlnp (dlemifreme, olfjndoxpj - viqdqjaoey)
Not Applicable
-
-
jdkikvkwji(xghgvuthmh) = bwwyleboud cmbxotmfxx (ruktuadbyq )
-
01 Jan 2011
-
Not Applicable
Second line
12
lcbzalksvr(zpvrvrdswv) = vagqvinuzp jixaokeghw (dkrembzszg )
-
01 Jan 2011
Not Applicable
HIV Infections
First line
-
ffvpqieyqv(clpphhbmzf): adjusted hazard ratio = 0.68 (95% CI, 0.51 - 0.91)
-
01 Aug 2009
Lopinavir boosted with ritonavir
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Regulation

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