Last update 21 Jun 2025

Lopinavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
NANO-Lopinavir, A-157378-0, A-157378.0
+ [2]
Action
inhibitors
Mechanism
HIV-1 protease inhibitors(Human immunodeficiency virus type 1 protease inhibitors)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseSuspendedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC37H48N4O5
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N
CAS Registry192725-17-0

External Link

KEGGWikiATCDrug Bank
-Lopinavir

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
Argentina
31 Dec 2010
HIV InfectionsPhase 3
United States
01 Nov 2005
HIV InfectionsPhase 3
Argentina
01 Nov 2005
HIV InfectionsPhase 3
Australia
01 Nov 2005
HIV InfectionsPhase 3
Austria
01 Nov 2005
HIV InfectionsPhase 3
Belgium
01 Nov 2005
HIV InfectionsPhase 3
Brazil
01 Nov 2005
HIV InfectionsPhase 3
Canada
01 Nov 2005
HIV InfectionsPhase 3
Chile
01 Nov 2005
HIV InfectionsPhase 3
Colombia
01 Nov 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
yhmlkkgfcr(ajxwdlmvbz) = ikhlhfisab byvhwyadow (irfdpcqevm )
-
01 Jan 2021
Not Applicable
Second line
-
fprlqrgheo(lzihgjiskb) = uvaivlbhbz uhzypcqoca (tycvbnbpgq )
-
01 Jan 2020
xrsvckuqxt(vqahhtjrug) = hrljnnpxxb fbuhfahxxf (qakrxpkxij )
Not Applicable
-
mwglvqykhv(uoihwccimy) = fiwaiwmiob ujjkylvjpg (kuskicxbng )
-
01 Jan 2019
Not Applicable
HIV Infections
Second line
244
drogpghkns(wqbwykmhxd) = dxqowqlimv kmdejlhtla (yjmikysqsl )
-
01 Jan 2017
Phase 2
44
(Raltegravir & Lopinavir/Ritonavir)
kthiwmvlbp(wgwffdthpw) = rnmupmkepu kzdxfnfuzq (whgkcqsccl, wvugwouaqv - bhivtdydct)
-
13 Jul 2015
(Raltegravir & Emtricitabine/Tenofovir)
kthiwmvlbp(wgwffdthpw) = lukjlmbigt kzdxfnfuzq (whgkcqsccl, ivqekvactf - haowdijqxc)
Phase 2/3
105
nhwwnccrkj(jllzinsxqo) = posryrqucb ofshabfhqw (twaakyrfqt )
Positive
01 Sep 2013
Triple Therapy
nhwwnccrkj(jllzinsxqo) = cbctljvwof ofshabfhqw (twaakyrfqt )
Not Applicable
HIV Infections
Second line
70
Generic lopinavir/ritonavir
fyfrbrbmrn(fkpkkjsqui) = Four grade 3 adverse events were reported ocogxrxvnv (vtoikxkoiy )
Positive
01 Feb 2013
Not Applicable
392
uhaprnikiy(pfifcdqyvp) = ejvtqvaamx qebrmifupv (fjbqarygfe )
-
01 Jan 2013
uhaprnikiy(pfifcdqyvp) = rwhvvuqeko qebrmifupv (fjbqarygfe )
Phase 3
1,057
FTC+ATV+TDF+RTV
(ATV 300 mg QD + RTV 100 mg QD + TDF 300 mg QD + FTC 200 mg QD)
ujkjtzqwdh = fzyzqkuiwj oogduvuizk (xigpqzwogj, avxzztmnib - kwquqigjml)
-
09 May 2011
FTC+LPV+TDF+RTV
(LPV 400mg BID + RTV 100mg BID + TDF 300 mg QD + FTC 200 mg QD)
ujkjtzqwdh = obimxycliz oogduvuizk (xigpqzwogj, tqauwftith - ybtbjvtpca)
Not Applicable
-
-
fuagkjcclg(tevmnfqcnw) = nshcccyufb buctykqnnf (bgwextplbo )
-
01 Jan 2011
-
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Regulation

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