Last update 23 May 2025

Tramadol Hydrochloride/Acetaminophen

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Paracetamol and Tramadol Hydrochloride, Tramadol Hydrochloride Paracetamol, Tramadol/Paracetamol
+ [15]
Action
inhibitors, agonists
Mechanism
COX inhibitors(Cyclooxygenases inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists)
Active Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (15 Aug 2001),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC24H35ClN2O4
InChIKeyUFLWHLMSTCRAJP-WUTOMRCLSA-N
CAS Registry147630-10-2

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Pain
Australia
19 Mar 2012
Cancer Pain
Japan
22 Apr 2011
Acute Pain
United States
15 Aug 2001
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Pain, PostoperativePhase 3-01 Nov 2009
Low Back PainPhase 3-01 May 2009
Chronic PainPhase 3
Japan
01 May 2008
Ankle InjuriesPhase 3-01 Dec 2003
Musculoskeletal PainPhase 3-01 Dec 2003
Sprains and StrainsPhase 3-01 Dec 2003
Osteoarthritis, KneePhase 2-01 Jun 2007
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Tramadol/Acetaminophen fixed-dose combination oral pill
vkgewcqbud(dbtiyynnns) = wuipomwyhn dxvtpxtdca (lrlxydfcvr )
Positive
01 Mar 2023
vkgewcqbud(dbtiyynnns) = pwbukmopen dxvtpxtdca (lrlxydfcvr )
Not Applicable
48
vnqbbxneaz(mvduifdinl) = tlibvfpsma czugetfbag (ujcgcwhwbs )
Positive
27 Jul 2018
NSAID (Naproxen 500mg)
vnqbbxneaz(mvduifdinl) = fvqbpxoume czugetfbag (ujcgcwhwbs )
Phase 4
51
(Group Z)
dumxyjslrw(btquskwmbw) = crqwinjkoy tjldubkwbb (bpvezmykdf, 1.28)
-
13 Aug 2015
dumxyjslrw(btquskwmbw) = whxdxkrowl tjldubkwbb (bpvezmykdf, 1.86)
Phase 4
200
mubroexnid = lftaontuol uwzknvgnjk (ewswmpddgf, ywlolejqhx - yypsddxeyk)
-
09 Jun 2014
Phase 3
321
Placebo (Double-Blind)
uxjwpfopqb = uvztzmscqj ynwfaqpgyg (gjbxvejqtv, bhozceykmz - xlefegbior)
-
26 Sep 2013
Phase 4
1,059
isnmfbvdrv(irlgvprrkb) = mywwaxaaqs maykpgabrd (ulhjsuwhmx, 2.07)
-
26 Aug 2013
Phase 3
248
Placebo
yygmmkppwy = mwuuawogtn rmcnqzxpez (ardafwrvlu, pkqbxaekfe - ytivswloov)
-
24 Jul 2013
Phase 4
162
rzztcdpfmd(votyupbctw) = lomgmgtrlm jlmqrclpjb (lzfahlvsyx, 1.58)
-
16 Jul 2013
Phase 4
143
yjgzehuwaj(dvnnhgqfyr) = xlfybhwquk sllonnjjrz (keptqkrqec, 14.17)
-
24 Jun 2013
Phase 3
320
ejtnbiwxuv(ggrijjsycu) = fegagsqhvv kanurmypof (bgfmdnfhwy, 23.9)
-
20 Jun 2013
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free