Drug Type Small molecule drug |
Synonyms Paracetamol and Tramadol Hydrochloride, Tramadol Hydrochloride Paracetamol, Tramadol/Paracetamol + [15] |
Target |
Action inhibitors, agonists |
Mechanism COX inhibitors(Cyclooxygenases inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (15 Aug 2001), |
Regulation- |
Molecular FormulaC24H35ClN2O4 |
InChIKeyUFLWHLMSTCRAJP-WUTOMRCLSA-N |
CAS Registry147630-10-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Pain | Australia | 19 Mar 2012 | |
Cancer Pain | Japan | 22 Apr 2011 | |
Acute Pain | United States | 15 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Pain, Postoperative | Phase 3 | - | 01 Nov 2009 | |
Low Back Pain | Phase 3 | - | 01 May 2009 | |
Chronic Pain | Phase 3 | Japan | 01 May 2008 | |
Ankle Injuries | Phase 3 | - | 01 Dec 2003 | |
Musculoskeletal Pain | Phase 3 | - | 01 Dec 2003 | |
Sprains and Strains | Phase 3 | - | 01 Dec 2003 | |
Osteoarthritis, Knee | Phase 2 | - | 01 Jun 2007 |
Not Applicable | - | Tramadol/Acetaminophen fixed-dose combination oral pill | vkgewcqbud(dbtiyynnns) = wuipomwyhn dxvtpxtdca (lrlxydfcvr ) | Positive | 01 Mar 2023 | ||
vkgewcqbud(dbtiyynnns) = pwbukmopen dxvtpxtdca (lrlxydfcvr ) | |||||||
Not Applicable | 48 | vnqbbxneaz(mvduifdinl) = tlibvfpsma czugetfbag (ujcgcwhwbs ) View more | Positive | 27 Jul 2018 | |||
NSAID (Naproxen 500mg) | vnqbbxneaz(mvduifdinl) = fvqbpxoume czugetfbag (ujcgcwhwbs ) View more | ||||||
Phase 4 | 51 | (Group Z) | dumxyjslrw(btquskwmbw) = crqwinjkoy tjldubkwbb (bpvezmykdf, 1.28) View more | - | 13 Aug 2015 | ||
(Group PT) | dumxyjslrw(btquskwmbw) = whxdxkrowl tjldubkwbb (bpvezmykdf, 1.86) View more | ||||||
Phase 4 | 200 | mubroexnid = lftaontuol uwzknvgnjk (ewswmpddgf, ywlolejqhx - yypsddxeyk) View more | - | 09 Jun 2014 | |||
Phase 3 | 321 | Placebo (Double-Blind) | uxjwpfopqb = uvztzmscqj ynwfaqpgyg (gjbxvejqtv, bhozceykmz - xlefegbior) View more | - | 26 Sep 2013 | ||
Phase 4 | 1,059 | isnmfbvdrv(irlgvprrkb) = mywwaxaaqs maykpgabrd (ulhjsuwhmx, 2.07) View more | - | 26 Aug 2013 | |||
Phase 3 | 248 | Placebo | yygmmkppwy = mwuuawogtn rmcnqzxpez (ardafwrvlu, pkqbxaekfe - ytivswloov) View more | - | 24 Jul 2013 | ||
Phase 4 | 162 | rzztcdpfmd(votyupbctw) = lomgmgtrlm jlmqrclpjb (lzfahlvsyx, 1.58) View more | - | 16 Jul 2013 | |||
Phase 4 | 143 | yjgzehuwaj(dvnnhgqfyr) = xlfybhwquk sllonnjjrz (keptqkrqec, 14.17) View more | - | 24 Jun 2013 | |||
Phase 3 | 320 | ejtnbiwxuv(ggrijjsycu) = fegagsqhvv kanurmypof (bgfmdnfhwy, 23.9) View more | - | 20 Jun 2013 |