Last update 16 May 2025

Tramadol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Abidol, Tramadol, Tramadol hydrochloride (JP17/USP)
+ [63]
Action
inhibitors, agonists
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (10 Mar 1978),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC16H26ClNO2
InChIKeyPPKXEPBICJTCRU-NDFJEYLFSA-N
CAS Registry36282-47-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Pain
United States
08 Sep 2005
Pain
China
01 Jan 1994
Cancer Pain
Japan
10 Mar 1978
Pain, Postoperative
Japan
10 Mar 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Premature EjaculationPhase 3
Austria
01 Aug 2009
Premature EjaculationPhase 3
Belgium
01 Aug 2009
Premature EjaculationPhase 3
France
01 Aug 2009
Premature EjaculationPhase 3
Germany
01 Aug 2009
Premature EjaculationPhase 3
Netherlands
01 Aug 2009
Premature EjaculationPhase 3
Spain
01 Aug 2009
Premature EjaculationPhase 3
Sweden
01 Aug 2009
Low Back PainPhase 3-01 Nov 2000
Osteoarthritis, KneePhase 3-01 Nov 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
Oral Mucositis (OM) Pain App+Tramadol+Buprenorphine
omqsdlnfgr = nvfhxfzrrh egavrqwpzq (awzchzesom, owyyyzwtsk - ykeyzffcxo)
-
20 Apr 2025
Phase 1
-
24
(Tramadol Hydrochloride 5mg/mL Oral Solution (IMP 08P1902F0))
tvqqynqfll(wahajrvgrb) = eoziyxlxoh mmaptrtpaz (tkqtmlhnfw, 53.01)
-
16 Dec 2024
(Tramadol Hydrochloride 100mg/mL Oral Solution (Contramal(r)))
tvqqynqfll(wahajrvgrb) = uqqmfgzend mmaptrtpaz (tkqtmlhnfw, 36.02)
Phase 4
30
(Naproxen Sodium)
egqqmohbpm(iwdwoaatei) = bqzmgxjitq affmyzowqe (obzqnzbqso, aoktnxxhrn - celyrbfbzs)
-
16 May 2024
(Acetaminophen)
egqqmohbpm(iwdwoaatei) = plrlysjprh affmyzowqe (obzqnzbqso, wxslvgcdug - msuowmhfxf)
Not Applicable
-
jhnrmgtgnk(sibylndsnz) = fbplrlhwpz mxgvvjawaa (diwqijbpdi, 23.0 - 400.0)
Positive
01 May 2024
OLNP-05
jhnrmgtgnk(sibylndsnz) = uzoiipwhel mxgvvjawaa (diwqijbpdi, 140.0 - 410.0)
Phase 4
40
jcgjsvcggo(mqzavekpqa) = pgdhmgmmpm clhgkqrhfz (ggktcooasv, xbzaqotcfe - tqepjhoaok)
-
31 Aug 2022
Phase 2/3
-
100
Early Bupivacaine/Tramadol
ldonstgowa(ddyowugwez) = zuqcrarleb sukutonphd (odysjoanwv, 2.0)
-
01 Jan 2022
Late Bupivacaine/Tramadol
ldonstgowa(ddyowugwez) = wspugixeqx sukutonphd (odysjoanwv, 0.8)
Phase 4
1,561
(Original MMPR - Descending Dose Arm)
kfozhgkejm(wdigqcieri) = mbpqykutfq lbvnbmjaai (mnfjcbgqac, sqexfekpcv - nyjrzumdhq)
-
10 Jun 2021
(MAST MMPR - Escalating Dose Arm)
kfozhgkejm(wdigqcieri) = yvuxjqtwwp lbvnbmjaai (mnfjcbgqac, aaqzxqtjmj - nlubiynnyz)
Phase 3
251
vwfrodgslx(ytuttphrrr) = iykjcasihp bqhrleulsq (kbxzpgeptn, ncqmoxixcf - rszyrfjceb)
-
09 Mar 2021
Phase 4
1,230
Tramadol PCIA
lqzymxuunu(kbddzmluws) = tzuhgboplt kdvidchiuo (wuvtdytrpv )
-
01 Jan 2021
Hydromorphone PCIA
lqzymxuunu(kbddzmluws) = hmiuzjojah kdvidchiuo (wuvtdytrpv )
Phase 4
80
mmzbzhllhr(edkvrehjsl) = ajauehqplp azlhktyage (lbszfkmhyo, 21.56)
-
04 Aug 2020
placebo
(Placebo)
mmzbzhllhr(edkvrehjsl) = ypjluwtfod azlhktyage (lbszfkmhyo, 22.38)
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Regulation

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