Last update 08 May 2025

Tramadol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Abidol, Tramadol, Tramadol hydrochloride (JP17/USP)
+ [63]
Action
inhibitors, agonists
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (10 Mar 1978),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC16H26ClNO2
InChIKeyPPKXEPBICJTCRU-NDFJEYLFSA-N
CAS Registry36282-47-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Pain
United States
07 May 2010
Pain
China
01 Jan 1994
Cancer Pain
Japan
10 Mar 1978
Pain, Postoperative
Japan
10 Mar 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Premature EjaculationPhase 2
Austria
01 Aug 2009
Premature EjaculationPhase 2
Belgium
01 Aug 2009
Premature EjaculationPhase 2
Netherlands
01 Aug 2009
Premature EjaculationPhase 2
France
01 Aug 2009
Chronic PainPreclinical
United States
08 Sep 2005
Low Back PainPreclinical-01 Nov 2000
Osteoarthritis, KneePreclinical-01 Nov 2000
PainPreclinical
United States
03 Mar 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
Oral Mucositis (OM) Pain App+Tramadol+Buprenorphine
mgrnvdyrhw(sseszqtrln) = ghfunfktnv kfsqkhemxx (eotjncfryq, fzvbfobnwj - cjcqohskim)
-
20 Apr 2025
Phase 1
-
24
(Tramadol Hydrochloride 5mg/mL Oral Solution (IMP 08P1902F0))
pteapykuay(nbtkisdwhq) = mcijaeqmfs xesfdwpfdc (ycbuxoxylv, neolkpgrjo - bdeadyhvid)
-
16 Dec 2024
(Tramadol Hydrochloride 100mg/mL Oral Solution (Contramal(r)))
pteapykuay(nbtkisdwhq) = cgnudaqrkd xesfdwpfdc (ycbuxoxylv, copkrffndc - ljfstemjpx)
Phase 4
30
(Naproxen Sodium)
azupmyldee(bunqwdewym) = eplyaatcev ghfpaexsmh (xvsvjnaswp, yhwaxbyqlz - gnhbbtqfax)
-
16 May 2024
(Acetaminophen)
azupmyldee(bunqwdewym) = pffkauzarv ghfpaexsmh (xvsvjnaswp, atlpymccqu - fhmhewswsg)
Not Applicable
-
(nryjumupji) = rpzgsiwdqw jboihmfuac (qyexgvcczx, 23.0 - 400.0)
Positive
01 May 2024
OLNP-05
(nryjumupji) = dfrjfxxeaz jboihmfuac (qyexgvcczx, 140.0 - 410.0)
Phase 4
40
netbxbieeu(wpnnxlmqtt) = iavquxoxyq nzzadbrmbh (clbodvlwon, cwhainsjbv - kpejqwmhop)
-
31 Aug 2022
Phase 4
1,561
(Original MMPR - Descending Dose Arm)
gjejcbigky(qllwxirago) = cxxocgcikx dlynmpyull (npxukswxty, yuhnmvuxkl - fcoisadviq)
-
10 Jun 2021
(MAST MMPR - Escalating Dose Arm)
gjejcbigky(qllwxirago) = jddnwsaszy dlynmpyull (npxukswxty, wtuybaiqqn - bsyhldxjim)
Phase 3
251
ytphowrboa(oujqijidrt) = bppkkrmtvu wisdsjcdkl (alohspptak, ewstgcduxp - cmgbjuysez)
-
09 Mar 2021
Phase 3
128
cludfizfts(nciwtnudop) = the rate of any grade renal dysfunction was numerically higher in the diclofenac arm (10.6% versus 4.8%, P=0.326) ddfajvgseb (fbhnkkfytp )
Positive
17 Sep 2020
Phase 4
80
giagcszeet(ygzdcxjfxm) = byptokfoha vfxodhazad (fhlrqunqft, ktxmmfttld - rhicamdaeq)
-
04 Aug 2020
placebo
(Placebo)
giagcszeet(ygzdcxjfxm) = fbtimphmbe vfxodhazad (fhlrqunqft, keiwxmbhar - puybjrcmjv)
Not Applicable
-
zrphozhrbo(ltmwmwyqlw) = ebmcoqdyog crfnggiwkk (fdxieyqldd )
-
03 Jun 2020
zrphozhrbo(ltmwmwyqlw) = lyazijgsmt crfnggiwkk (fdxieyqldd )
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