Drug Type Small molecule drug |
Synonyms Abidol, Tramadol, Tramadol hydrochloride (JP17/USP) + [63] |
Target |
Action inhibitors, agonists |
Mechanism NET inhibitors(Norepinephrine transporter inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (10 Mar 1978), |
RegulationOrphan Drug (United States) |
Molecular FormulaC16H26ClNO2 |
InChIKeyPPKXEPBICJTCRU-NDFJEYLFSA-N |
CAS Registry36282-47-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01355 | Tramadol Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic Pain | United States | 08 Sep 2005 | |
Pain | China | 01 Jan 1994 | |
Cancer Pain | Japan | 10 Mar 1978 | |
Pain, Postoperative | Japan | 10 Mar 1978 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Premature Ejaculation | Phase 3 | Austria | 01 Aug 2009 | |
Premature Ejaculation | Phase 3 | Belgium | 01 Aug 2009 | |
Premature Ejaculation | Phase 3 | France | 01 Aug 2009 | |
Premature Ejaculation | Phase 3 | Germany | 01 Aug 2009 | |
Premature Ejaculation | Phase 3 | Netherlands | 01 Aug 2009 | |
Premature Ejaculation | Phase 3 | Spain | 01 Aug 2009 | |
Premature Ejaculation | Phase 3 | Sweden | 01 Aug 2009 | |
Low Back Pain | Phase 3 | - | 01 Nov 2000 | |
Osteoarthritis, Knee | Phase 3 | - | 01 Nov 2000 |
Phase 2 | 20 | omqsdlnfgr = nvfhxfzrrh egavrqwpzq (awzchzesom, owyyyzwtsk - ykeyzffcxo) View more | - | 20 Apr 2025 | |||
Phase 1 | - | 24 | (Tramadol Hydrochloride 5mg/mL Oral Solution (IMP 08P1902F0)) | tvqqynqfll(wahajrvgrb) = eoziyxlxoh mmaptrtpaz (tkqtmlhnfw, 53.01) View more | - | 16 Dec 2024 | |
(Tramadol Hydrochloride 100mg/mL Oral Solution (Contramal(r))) | tvqqynqfll(wahajrvgrb) = uqqmfgzend mmaptrtpaz (tkqtmlhnfw, 36.02) View more | ||||||
Phase 4 | 30 | egqqmohbpm(iwdwoaatei) = bqzmgxjitq affmyzowqe (obzqnzbqso, aoktnxxhrn - celyrbfbzs) View more | - | 16 May 2024 | |||
(Acetaminophen) | egqqmohbpm(iwdwoaatei) = plrlysjprh affmyzowqe (obzqnzbqso, wxslvgcdug - msuowmhfxf) View more | ||||||
Not Applicable | - | jhnrmgtgnk(sibylndsnz) = fbplrlhwpz mxgvvjawaa (diwqijbpdi, 23.0 - 400.0) | Positive | 01 May 2024 | |||
OLNP-05 | jhnrmgtgnk(sibylndsnz) = uzoiipwhel mxgvvjawaa (diwqijbpdi, 140.0 - 410.0) | ||||||
Phase 4 | 40 | jcgjsvcggo(mqzavekpqa) = pgdhmgmmpm clhgkqrhfz (ggktcooasv, xbzaqotcfe - tqepjhoaok) View more | - | 31 Aug 2022 | |||
Phase 2/3 | - | 100 | Early Bupivacaine/Tramadol | ldonstgowa(ddyowugwez) = zuqcrarleb sukutonphd (odysjoanwv, 2.0) | - | 01 Jan 2022 | |
Late Bupivacaine/Tramadol | ldonstgowa(ddyowugwez) = wspugixeqx sukutonphd (odysjoanwv, 0.8) | ||||||
Phase 4 | 1,561 | (Original MMPR - Descending Dose Arm) | kfozhgkejm(wdigqcieri) = mbpqykutfq lbvnbmjaai (mnfjcbgqac, sqexfekpcv - nyjrzumdhq) View more | - | 10 Jun 2021 | ||
(MAST MMPR - Escalating Dose Arm) | kfozhgkejm(wdigqcieri) = yvuxjqtwwp lbvnbmjaai (mnfjcbgqac, aaqzxqtjmj - nlubiynnyz) View more | ||||||
Phase 3 | 251 | vwfrodgslx(ytuttphrrr) = iykjcasihp bqhrleulsq (kbxzpgeptn, ncqmoxixcf - rszyrfjceb) View more | - | 09 Mar 2021 | |||
Phase 4 | 1,230 | Tramadol PCIA | lqzymxuunu(kbddzmluws) = tzuhgboplt kdvidchiuo (wuvtdytrpv ) | - | 01 Jan 2021 | ||
Hydromorphone PCIA | lqzymxuunu(kbddzmluws) = hmiuzjojah kdvidchiuo (wuvtdytrpv ) | ||||||
Phase 4 | 80 | (Tramadol) | mmzbzhllhr(edkvrehjsl) = ajauehqplp azlhktyage (lbszfkmhyo, 21.56) View more | - | 04 Aug 2020 | ||
placebo (Placebo) | mmzbzhllhr(edkvrehjsl) = ypjluwtfod azlhktyage (lbszfkmhyo, 22.38) View more |