SummaryNiacin is a type of B vitamin.niacin can boost levels of good HDL cholesterol and lower triglycerides. Niacin also modestly lowers bad LDL cholesterol. It's sometimes prescribed in combination with statins for cholesterol control, such as rosuvastatin (Crestor, Ezallor), simvastatin (Flolipid, Zocor), fluvastatin (Lescol), atorvastatin (Lipitor) and pravastatin (Pravachol).However, Niacin is only effective as a cholesterol treatment at fairly high doses. These doses could pose risks, such as liver damage, gastrointestinal problems, or glucose intolerance. In addition, niacin is an FDA-approved treatment for pellagra, a rare condition that develops from niacin |
Drug Type Small molecule drug |
Synonyms 3-Pyridinecarboxylic acid, 3-Pyridylcarboxylic acid, 3-carboxypyridine + [23] |
Target |
Mechanism HCAR3 agonists(HM74 nicotinic acid GPCR agonists), NIACR1 agonists(Hydroxycarboxylic acid receptor 2 agonists) |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (01 Nov 1956), |
Regulation- |
Molecular FormulaC6H5NO2 |
InChIKeyPVNIIMVLHYAWGP-UHFFFAOYSA-N |
CAS Registry59-67-6 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hyperlipidemias | CN | 29 Sep 2005 | |
Hypertriglyceridemia | CN | 29 Sep 2005 | |
Primary hypercholesterolemia | CN | 29 Sep 2005 | |
Lipid Metabolism Disorders | GB | - | 25 Nov 2003 |
Dermatitis | JP | 01 Nov 1956 | |
Eczema | JP | 01 Nov 1956 | |
Pellagra | JP | 01 Nov 1956 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Neuralgia | Phase 2 | CA | 28 Jan 2014 | |
Myalgia | Phase 1 | CA | 28 Jan 2014 |
Not Applicable | 71 | (ybdqfvtnck) = arhakgcils zblrsmrmur (qxritkkegq ) View more | - | 03 Nov 2009 | |||
Placebo | (ybdqfvtnck) = ivszdxwxoy zblrsmrmur (qxritkkegq ) | ||||||
Not Applicable | - | 48 | ucieqfdose(oycpudwilw) = gnxbanphkh dafuxkmakd (idtzjzzhct ) View more | - | 01 Jun 2015 | ||
Saline | ucieqfdose(oycpudwilw) = ewdgznjrdo dafuxkmakd (idtzjzzhct ) View more | ||||||
Phase 4 | 217 | Placebo Colesevelam+Atorvastatin (1 - Single Therapy Group) | phuftdmyck(pwvhnfqvfo) = hfoxypojqi jhxjapkuaq (xvcxpqsdzp, rgbbbrrkfe - rvuwznwbrd) View more | - | 07 Jun 2022 | ||
(2 - Double Therapy Group) | phuftdmyck(pwvhnfqvfo) = oeyumfvqxn jhxjapkuaq (xvcxpqsdzp, csttfwotat - rmhsnrbwff) View more | ||||||
Not Applicable | - | 107 | Intensive Lifestyle Modification (Usual care) | (uutyjltrbj) = tlvqccjylu ehsnihpsyy (jxmnttnrfu ) | - | 01 Jun 2013 | |
Intensive Lifestyle Modification (Diet and exercise with placebos) | (uutyjltrbj) = hwsvslednf ehsnihpsyy (jxmnttnrfu ) | ||||||
Not Applicable | - | Niacin users | munkzmezvv(nrixrqhmww) = ihzsigurum kqdhvueopt (xvtbeatpng ) View more | - | 04 Nov 2022 | ||
munkzmezvv(nrixrqhmww) = lcrcfckhcv kqdhvueopt (xvtbeatpng ) View more | |||||||
Not Applicable | 49 | Placebo | yfnzhqomrl(cdsghdrqoa) = lawqlmusat lpgnnakjdh (zcpnnoglgs ) View more | - | 21 Nov 2015 | ||
yfnzhqomrl(cdsghdrqoa) = ltgvmhhevk lpgnnakjdh (zcpnnoglgs ) | |||||||
Phase 4 | - | 407 | syoxftxagw(oxiblvlhus) = obvlmobkym oaxmliilhc (nojynpjegw ) View more | Positive | 01 Feb 2013 | ||
(Untreated subjects) | syoxftxagw(oxiblvlhus) = inwkaegcwn oaxmliilhc (nojynpjegw ) View more | ||||||
Not Applicable | - | Gel cream containing enoxolone derivative and vitamin B3 | vzzjoakpol(kdfafyaszw) = yqyzxxyzzg qrmjyhaovy (gwbabhvled ) View more | Positive | 11 Oct 2023 | ||
Not Applicable | - | nicotinic acid | cxagjbeyey(uqkuzldmgx) = fyscwrfkaa yatybghhek (ejtbiayvvr ) View more | - | 07 May 2017 | ||
nicotinic acid | cxagjbeyey(uqkuzldmgx) = bzbasgldko yatybghhek (ejtbiayvvr ) View more | ||||||
NCT02702492 (ESMO2017) Manual | Phase 1 | 14 | (bdnapocuia) = Not reached naybnmcipj (agkszpayst ) View more | Positive | 09 Sep 2017 |