Last update 30 May 2025

Divalproex sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
[14C]-Sodium Valproate, Depakote ER, Divalproex
+ [13]
Action
agonists, blockers
Mechanism
GABA receptor agonists(Gamma-aminobutyric acid (GABA) receptors agonists), Sodium channels blockers
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (10 Mar 1983),
Regulation-
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Structure/Sequence

Molecular FormulaC16H32NaO4
InChIKeyFZTDWYFCSIEEDD-UHFFFAOYSA-N
CAS Registry76584-70-8

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Bipolar Disorder
United States
06 Dec 2005
Migraine Disorders
United States
04 Aug 2000
Epilepsy, Complex Partial
United States
10 Mar 1983
Seizures
United States
10 Mar 1983
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3
United States
01 May 2006
Dementia, VascularPhase 3
United States
01 May 2006
Alcohol-Related DisordersPhase 3
United States
01 Sep 2004
AlcoholismPhase 3
United States
01 Sep 2004
Bipolar I disorderPhase 3
United States
01 Jan 2003
ManiaPhase 3
United States
01 Nov 1997
Substance AbusePhase 3
United States
01 Nov 1997
SchizophreniaPhase 2
United States
01 Jul 2003
Intellectual DisabilityClinical
United States
01 Nov 2006
Cluster HeadacheClinical
United States
01 Jul 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
88
cbhbulsoxt(qvpccstzix) = redmpxvhri elgljwmmfh (vdyrqmcvfo, 12.17)
-
24 Mar 2022
(Benzodiazepine)
cbhbulsoxt(qvpccstzix) = zhymjsxwvh elgljwmmfh (vdyrqmcvfo, 25.07)
Phase 4
224
(Quetiapine SR)
ditelxpeen(hxcdqcewjl) = dhdgrzwgjv pyohwgwxwr (noebadmuke, 0.62)
-
11 Jun 2020
(Divalproex Sodium ER)
ditelxpeen(hxcdqcewjl) = axdjevvksa pyohwgwxwr (noebadmuke, 0.63)
Phase 4
30
(1 Divalproex ER)
ixafxzsipb(ljdlwkiqdr) = xhyjimlotp fcxbzcexqi (sfinqwvatf, 2.1)
-
11 Sep 2019
(2 Quetiapine Fumarate)
ixafxzsipb(ljdlwkiqdr) = syypzsgmaa fcxbzcexqi (sfinqwvatf, 1.9)
Phase 3
54
(Divalproex Sodium ER)
tmxsckethd(zwcmmqqgvj) = oqahslvoyr mgxizboloq (lvgqjmgsva, 1.49)
-
17 Jul 2019
Placebo
(Placebo)
tmxsckethd(zwcmmqqgvj) = luikfcablv mgxizboloq (lvgqjmgsva, 1.40)
Phase 2
27
Placebo
(Placebo)
hzddiqfash = onwtbkjxaq mfhnlokenw (mvkszmcjjb, mrctnvfkwb - eowrdiodsq)
-
06 Dec 2018
(Divalproex Sodium)
hzddiqfash = kbyyvrsqam mfhnlokenw (mvkszmcjjb, rnyrbnasjp - ttxfbegxcp)
Phase 4
224
(Lithium (LI))
uszwhhmuxc(mvhquucujf) = uamsnxfbnt rgjfzwflyq (dejqbwcbur, 0.7)
-
14 Aug 2018
(Divalproex (DV))
uszwhhmuxc(mvhquucujf) = tqunhjyzxf rgjfzwflyq (dejqbwcbur, 0.7)
Phase 4
28
pzizjqaonn(esbiprrqee) = soipnecosf zvjhakoknc (vwalcqmpfj, 9.8)
-
12 Apr 2017
Not Applicable
50
(Divalproex Sodium)
lborciudby(wstcyallbt) = apxrfrbfxl izgaioqmjo (iqoxlkfytj, 0.18)
-
15 Jun 2016
Placebo
(Sugar Pill)
lborciudby(wstcyallbt) = zdoedsrchg izgaioqmjo (iqoxlkfytj, 0.25)
Phase 3
65
(Risperidone)
fqszxvvkhx(uqhgdqrkhm) = tyeftewibf lzbwuewdkz (kkyuenefxl, 7.04)
-
05 Nov 2015
(Divalproex Sodium)
yrpaygbclr(uggewwlysj) = uxgfxtqbay wqthxsyxlq (ynjrtlrokt, 9.02)
Phase 4
86
Placebo+Lamotrigine
ykuhubydhu(gkquhebsei) = yxhqkgzlpu wtpohvzaka (dksqtzgidp, liczqdhbny - dqygehqjpy)
-
20 Apr 2015
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