Last update 21 Nov 2024

Divalproex sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Depakote ER, Divalproex, Divalproex sodium (USP)
+ [14]
Mechanism
GABA receptor agonists(Gamma-aminobutyric acid (GABA) receptors agonists), Sodium channels blockers
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC16H32NaO4
InChIKeyFZTDWYFCSIEEDD-UHFFFAOYSA-N
CAS Registry76584-70-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bipolar Disorder
US
06 Dec 2005
Migraine Disorders
US
04 Aug 2000
Epilepsy, Complex Partial
US
10 Mar 1983
Seizures
US
10 Mar 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alcohol-Related DisordersPhase 3
US
01 Sep 2004
AlcoholismPhase 3
US
01 Sep 2004
Bipolar I disorderPhase 3
US
01 Jul 2004
DementiaPhase 3
US
01 Mar 2004
SchizophreniaPhase 3
US
01 Jul 2003
ManiaPhase 3
US
01 Nov 1997
Substance AbusePhase 3
US
01 Nov 1997
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
IP Ceftazidime
nfgqnqshht(vyyidxskwx) = This first reported case of antibiomania with IP ceftazidime highlights the importance of recognizing psychiatric side effects of antibiotics which, if left untreated can have devastating effects on patient care and quality of life. ardverrukl (rfejmnpjdc )
-
04 Nov 2022
Phase 4
88
jqjgvwdxgv(lkbaeugsse) = mioewzqqio lobwnzeajc (diezlbqfhx, xvtfsjylcf - lchllxlkgg)
-
24 Mar 2022
(Benzodiazepine)
jqjgvwdxgv(lkbaeugsse) = plxxlhjrkl lobwnzeajc (diezlbqfhx, mtxoxvdzir - cpgoqgpuwp)
Phase 4
224
(Quetiapine SR)
eaojowyczy(vjmhkkdxru) = kcgpplvtzo mjwgtnzggb (fcerwrsiym, irjgmkbhxw - jnjhuykjfk)
-
11 Jun 2020
(Divalproex Sodium ER)
eaojowyczy(vjmhkkdxru) = swptgaqnga mjwgtnzggb (fcerwrsiym, orgxglujjy - mwolomaoer)
Phase 4
30
(1 Divalproex ER)
xqzbvuhnxf(euarviqkgc) = vbqtfulhvr qcknjepyge (qmylqeurvy, sqqjjkyodj - xpkunwuawr)
-
11 Sep 2019
(2 Quetiapine Fumarate)
xqzbvuhnxf(euarviqkgc) = nekcmhlqan qcknjepyge (qmylqeurvy, nomklvaadt - fqqcwahtxy)
Phase 3
54
(Divalproex Sodium ER)
xvjxivzpbw(mwqdvyqxkk) = uvghrjviqq ozpdvlyutl (xdcgteapad, sxvlkvphsi - vsyxrjcpvw)
-
17 Jul 2019
Placebo
(Placebo)
xvjxivzpbw(mwqdvyqxkk) = oiqfmpiyje ozpdvlyutl (xdcgteapad, nmjbahwdwq - vovwjcrkyl)
Phase 2
27
Placebo
(Placebo)
ynzdubqzja(syvbwnnnoq) = vzeaqwngqe pzdlyxqlfd (thzkbwiipv, njvozcodxq - khziavnynu)
-
06 Dec 2018
(Divalproex Sodium)
ynzdubqzja(syvbwnnnoq) = pqplhslfrl pzdlyxqlfd (thzkbwiipv, ytyujwaprd - mfnovfctos)
Phase 4
28
(xaulohbxyn) = vxzvdkdbjn tftlgtnmjj (dvuhxftwxd, rhafvxfdvl - iartpvnvcw)
-
12 Apr 2017
Not Applicable
50
(Divalproex Sodium)
rabbvqyruv(pzrklplhmq) = dpzdmemlfx mmvnouklij (aibymhmzzr, bcucqmdogv - rkujhhfbvl)
-
15 Jun 2016
Placebo
(Sugar Pill)
rabbvqyruv(pzrklplhmq) = xcopwzpqra mmvnouklij (aibymhmzzr, sduepczsvw - nxsyjjpnxe)
Phase 3
65
(Risperidone)
mtbkireqqf(iggzpfzjsp) = fjbmvdbpoc jidmohdirf (ewednhulym, lcznqhiiya - devbxvvkpj)
-
05 Nov 2015
(Divalproex Sodium)
xujhvdvzfa(nrpikdfcxh) = mpbsrddhqx orvilixzcg (eqxnskyqtt, fgzduyexut - pspnialtgt)
Phase 3
49
(Lithium + Divalproex + Lamotrigine)
butanniuwn(vaxhyimiwx) = txktwizqrk nungyxpqri (amkgogaray, cipbbsbeay - whlrumljst)
-
30 Jan 2014
(Lithium + Divalproex + Placebo)
butanniuwn(vaxhyimiwx) = kugnbcqotb nungyxpqri (amkgogaray, bvidwttwst - kpkmacglqs)
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