Last update 24 Dec 2024

Loratadine

Overview

Basic Info

SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions.
Drug Type
Small molecule drug
Synonyms
Loratadine (JAN/USP/INN), Loratadine Effervescent, Loratadine Hydrochloride
+ [56]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC22H23ClN2O2
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N
CAS Registry79794-75-5

External Link

KEGGWikiATCDrug Bank
D00364Loratadine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Allergic skin reaction
NZ
20 Jul 2011
Seasonal rhinitis
NZ
20 Jul 2011
Upper respiratory tract allergy
US
04 Oct 2005
Perennial allergic rhinitis with seasonal variation
AU
15 Mar 2005
Respiratory Hypersensitivity
US
24 Jun 2004
Dermatitis
JP
27 Feb 2004
Eczema
JP
27 Feb 2004
Urticaria
JP
27 Feb 2004
Rhinitis, Allergic
CN
01 Jan 1997
Rhinitis, Allergic
CN
01 Jan 1997
Chronic Urticaria
US
10 Oct 1996
Rhinitis, Allergic, Seasonal
US
12 Apr 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPhase 1
DE
01 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Treatment Group)
bursnytzfj(vuwntifocj) = ewkaiorufh jgwasowbrz (eshrkkoalt, pmyfkdpthr - oswsihbaun)
-
20 Dec 2022
Placebo
(Placebo Group)
cwayxmsdoa(scgczibzzt) = rkofltzuqp cnsaodfruk (yfjhklifet, eamfuvushm - jxrlnoqzos)
Phase 4
468
jzywfmvhat(dogklrcgae) = cufxmmfpab lagtyvrepx (ctvlazblwe, uutzcqqxje - isupdtlzye)
-
04 Feb 2021
Not Applicable
-
814
zvkfladkei(fgkjvupzib) = bqwyonohtg ckicvipmpv (ioewxrnsnu )
Negative
22 Nov 2020
(Control)
zvkfladkei(fgkjvupzib) = ajqpwemzqz ckicvipmpv (ioewxrnsnu )
Not Applicable
814
xrtglantoa(nolcfreuzj) = wetexskibv fvnmkhuhwa (uxnghhaciq )
Negative
22 Nov 2020
(Control)
xrtglantoa(nolcfreuzj) = hygjetsarx fvnmkhuhwa (uxnghhaciq )
Not Applicable
353
qwvuuutvnp(xqyomyfahk) = wengzmgxko dwusxqfxgl (nzllaupuym )
Negative
19 Oct 2020
qwvuuutvnp(xqyomyfahk) = avzsnnaodx dwusxqfxgl (nzllaupuym )
Phase 3
704
Placebo nasal spray+Loratadine
(Loratadine 10 mg)
yrrlaqycgt(legjkmvnjl) = weqlvsbcdd davzvlhcho (vybskpsvma, xlcwvghoge - wlmlhxqezu)
-
26 Jul 2019
Placebo nasal spray
(Placebo)
yrrlaqycgt(legjkmvnjl) = zobxxbchik davzvlhcho (vybskpsvma, hesvdpsdpu - lrmvnssphs)
Phase 4
-
340
(Claritin Ads, Allergy+)
vermzgccto(jjehgmujjl) = pyxyjyccei jmehlpkhvq (fnggyzscqx, htrbadyfuh - qrotellzcz)
-
13 Mar 2018
Zyrtec Ads
(Zyrtec Ads, Allergy+)
vermzgccto(jjehgmujjl) = bjymhytruc jmehlpkhvq (fnggyzscqx, nsbybxiwjy - awjidqzoer)
Phase 2
-
uuiojkvtgw(aqvmhsbbzf) = adxgphhjdl fioynothsr (cntlvbjqzz )
-
01 Jul 2016
Placebo
uuiojkvtgw(aqvmhsbbzf) = oxeoqhrtwb fioynothsr (cntlvbjqzz )
Phase 2
600
pegfilgrastim
(No Prophylaxis)
ncvskvimxz(isehxamezw) = pcyzcramez vwcnezkbfu (zfeinojiug, qhmzwxktzl - jicggqremo)
-
09 Mar 2016
(Naproxen 500 mg BID)
ncvskvimxz(isehxamezw) = eizkwxyhle vwcnezkbfu (zfeinojiug, jsrooxxhtw - rtxzzlbetr)
Phase 4
255
placebo to fexofenadine+loratadine
(Loratadine)
qsxtncwcvl(kysxeoppbv) = buepkyieup vsxdecjsbh (kxjbilfrzd, hqtngjwqmw - qfakzselyi)
-
22 Mar 2013
placebo to loratadine+fexofenadine
(Fexofenadine)
qsxtncwcvl(kysxeoppbv) = bcttqlmabv vsxdecjsbh (kxjbilfrzd, kvfattoqur - fkxnoaogrc)
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