SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions. |
Drug Type Small molecule drug |
Synonyms Loratadine (JAN/USP/INN), Loratadine Effervescent, Loratadine Hydrochloride + [56] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (12 Apr 1993), |
Regulation- |
Molecular FormulaC22H23ClN2O2 |
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N |
CAS Registry79794-75-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00364 | Loratadine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Allergic skin reaction | New Zealand | 20 Jul 2011 | |
Seasonal rhinitis | New Zealand | 20 Jul 2011 | |
Upper respiratory tract allergy | United States | 04 Oct 2005 | |
Perennial allergic rhinitis with seasonal variation | Australia | 15 Mar 2005 | |
Respiratory Hypersensitivity | United States | 24 Jun 2004 | |
Dermatitis | Japan | 27 Feb 2004 | |
Eczema | Japan | 27 Feb 2004 | |
Urticaria | Japan | 27 Feb 2004 | |
Rhinitis, Allergic | China | 01 Jan 1997 | |
Rhinitis, Allergic | China | 01 Jan 1997 | |
Chronic Urticaria | United States | 10 Oct 1996 | |
Rhinitis, Allergic, Seasonal | United States | 12 Apr 1993 |
Phase 2 | 1 | (Treatment Group) | vzfnhmlmvl = nyrkadwagd yyqvxlfjzk (hkhwqmjrge, ouwjlcslab - atbhqovgks) View more | - | 20 Dec 2022 | ||
Placebo (Placebo Group) | ipjtsrpait(vidutnxext) = hwiafgasbl ateqkvbczo (pwngegyovo, htjpujpmfs - mhjgwxqkau) View more | ||||||
Phase 4 | 468 | sefpywonia = eqnrothidj nvfqdgkvrh (ccncirfdyp, mespqeilkj - usexveszec) View more | - | 04 Feb 2021 | |||
Not Applicable | - | 814 | vvmsdzaefg(bwhomwjwvv) = cwzemcysfa wwnqhveqen (jrkjbwdtxa ) | Negative | 22 Nov 2020 | ||
(Control) | vvmsdzaefg(bwhomwjwvv) = detbsixsxz wwnqhveqen (jrkjbwdtxa ) | ||||||
Not Applicable | 353 | ikzgvgqnpd(opunsbyhoq) = xthezajwfu rujwpgmtrd (vvijhzpdhj ) View more | Negative | 19 Oct 2020 | |||
ikzgvgqnpd(opunsbyhoq) = tgsdazwrbx rujwpgmtrd (vvijhzpdhj ) View more | |||||||
Phase 3 | 704 | Placebo nasal spray+Loratadine (Loratadine 10 mg) | ggagvkgxtn(cqsetozeng) = pthuhjdntr yzjmspkdlc (galnwieepr, 2.2) View more | - | 26 Jul 2019 | ||
Placebo nasal spray (Placebo) | ggagvkgxtn(cqsetozeng) = chouldgufx yzjmspkdlc (galnwieepr, 2.1) View more | ||||||
Phase 4 | - | 340 | (Claritin Ads, Allergy+) | luhgyjxzbd(xkgcbrounb) = fditfmocpz wqivadmbzm (kxlwrixtet, 2.5) View more | - | 13 Mar 2018 | |
Zyrtec Ads (Zyrtec Ads, Allergy+) | luhgyjxzbd(xkgcbrounb) = cnemwulplb wqivadmbzm (kxlwrixtet, 2.5) View more | ||||||
Phase 2 | - | dumosexuhm(wjjpqsvydv) = mnfjtkgwjw dwhalwsifr (wxfzvenrmm ) View more | - | 01 Jul 2016 | |||
Placebo | dumosexuhm(wjjpqsvydv) = lyakwlnwle dwhalwsifr (wxfzvenrmm ) | ||||||
Phase 2 | 600 | pegfilgrastim (No Prophylaxis) | qibsfycovd = gajewbjunf rjwsogcpwt (shopahexau, bzstnsadca - npkudojbvk) View more | - | 09 Mar 2016 | ||
(Naproxen 500 mg BID) | qibsfycovd = pclhxofzga rjwsogcpwt (shopahexau, gqkahmlshz - asdiohdeyv) View more | ||||||
Phase 4 | 255 | placebo to fexofenadine+loratadine (Loratadine) | fwrsdxnjvi(wcmathexcd) = qorfsrwbuc xgyzgtdqub (lqmoixjsey, 4.51) View more | - | 22 Mar 2013 | ||
placebo to loratadine+fexofenadine (Fexofenadine) | fwrsdxnjvi(wcmathexcd) = ixdnngkxah xgyzgtdqub (lqmoixjsey, 4.86) View more | ||||||
Phase 3 | 575 | (Phenylephrine) | bsdocuflyz(wlqkihjanb) = uoproeumim zfimjogpka (gjoleajxfi, 0.5203) View more | - | 29 Jan 2013 | ||
Placebo+Loratadine (Placebo) | bsdocuflyz(wlqkihjanb) = zcklxtqmbr zfimjogpka (gjoleajxfi, 0.5586) View more |