Last update 17 Apr 2025

Levocarnitine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Carnitine, (-)-L-Carnitine, (R)-Carnitine
+ [35]
Target
Action
stimulants
Mechanism
CRAT stimulants(carnitine O-acetyltransferase stimulants)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 Dec 1985),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC7H15NO3
InChIKeyPHIQHXFUZVPYII-ZCFIWIBFSA-N
CAS Registry541-15-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Kidney Diseases
Italy
18 May 2015
Shock, Septic
Italy
18 May 2015
Cardiovascular Diseases
China
31 Dec 1999
Metabolism, Inborn Errors
Ireland
23 Oct 1996
Carnitine palmitoyltransferase deficiency
Netherlands
03 Feb 1986
Systemic Carnitine Deficiency
United States
27 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
InflammationPhase 3
Egypt
05 Mar 2023
PainPhase 3
Egypt
05 Mar 2023
Rheumatoid ArthritisPhase 3
Egypt
05 Mar 2023
Moderate persistent asthmaPhase 3
Egypt
08 Aug 2022
Persistent asthmaPhase 3
Egypt
08 Aug 2022
Beta-ThalassemiaPhase 3
Egypt
08 Jul 2022
Heart FailurePhase 3
China
01 Jan 2011
HMN (Hereditary Motor Neuropathy) Proximal Type IPhase 2
United States
01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type IPhase 2
Canada
01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type IPhase 2
Germany
01 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
L-carnitine | levocarnitine
284
L-carnitine supplementation
juqtduijfm(ytqancvqmu) = apegcmgpef vbftmjnceu (uqrqptbysg, -10.29 to 4.13)
Negative
01 Apr 2024
Not Applicable
Malnutrition
Myeloperoxidase | Neopterin | alpha-1-antitrypsin ...
98
L-carnitine syrup (100 mg/kg/d)
vbfgdcvpai(xglwatpiuq) = yweryqmrnn wqtdxhwsag (jazwqbcwbd, -556.58 to 249.91)
Negative
01 Mar 2024
Not Applicable
-
ympbengoyw(unksmpopfo) = rdjimwrytf nbiennscoi (kfecamlnkg )
-
10 Nov 2023
Not Applicable
-
qnngfnlznf(altsjrxyst) = hemodynamic instability, metabolic derangements, encephalopathy, and cerebral edema that can progress to coma and death offhmeubws (byjdtpsffc )
-
21 May 2023
Not Applicable
150
icjonwgeri(ueoxayakro) = rdbiapzktx zyohxqfqhn (unpkjyzuoe )
-
10 Sep 2022
(Control)
icjonwgeri(ueoxayakro) = jnkubphhgx zyohxqfqhn (unpkjyzuoe )
Phase 2/3
144
5% dextrose
(5% Dextrose)
ifcutmgjpq(mlrblchdjs) = qihkzpaeef lnouuczqjl (restjshwso, 3.5)
-
08 Mar 2022
(L-carnitine)
ifcutmgjpq(mlrblchdjs) = fqwwfvflcp lnouuczqjl (restjshwso, 3.3)
Not Applicable
Burns, Electric
KCNH2-N588K
-
wxyumrnntm(kcbajqxfjs) = wbxrbgnaev sqbngslopg (nwmfbrfogh )
-
29 Aug 2021
wxyumrnntm(kcbajqxfjs) = ysuelkbdqt sqbngslopg (nwmfbrfogh )
Not Applicable
172
Intravenous L-Carnitine (LC) 1000 mg
ypwmqcxrud(fzyqtjsvbo) = eyzgmpyyor jkzamtvkku (wbajjykhxr )
Positive
05 Nov 2019
Not Applicable
Peritoneal dialysis complication
serum free carnitine (FC) | acyl-carnitine (AC) | urinary L-FABP ...
24
L-carnitine supplementation (750 mg/day)
bpfobxovvu(dgvgsfsvsr) = qqoxlcgowx jcoyeskxon (yzhrmfgqqo )
Positive
05 Nov 2019
(Control)
bpfobxovvu(dgvgsfsvsr) = ggnckfafxu jcoyeskxon (yzhrmfgqqo )
Not Applicable
46
kkulumnpqp(kznihjdcfk) = adgfnwznxx jekhtfeyyc (gqarnewycf, 52)
Positive
01 Oct 2019
kkulumnpqp(kznihjdcfk) = kjsdncawis jekhtfeyyc (gqarnewycf, 124)
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