Scientists from the University of Oxford, University of Cambridge, and The Pirbright Institute in the UK have discovered a potential new treatment approach for poxviruses like monkeypox and smallpox viruses.

Interleukin-2 (IL-2) in particular has undergone extensive engineering attempts to generate IL-2 variants with selective activities.

Researchers have made significant progress in understanding the role of NLRP3 signaling in the aging process of podocytes, a type of kidney cell.

Dolutegravir, a widely used antiretroviral drug, has shown excellent efficacy in treating HIV in adults. However, concerns have been raised about its potential neuropsychiatric side effects, which prompted the investigation into its impact on younger populations.

This study first revealed that dexmedetomidine inhibits the microglial synaptic elimination process mediated by the complement C3-C3aR signaling pathway.

The study, titled "Netrin-1 blockade inhibits tumor growth and EMT features in endometrial cancer," presents compelling evidence of the efficacy of a novel anti-Netrin-1 antibody in reducing tumor progression and inhibiting epithelial-to-mesenchymal transition (EMT).

cGAS-STING is a molecular signaling pathway involving two proteins, cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).

The success of CAR-T in hematologic malignancies lays the foundation for treating solid tumors, and oncology results will provide crucial knowledges for converting CAR-T to other diseases.

As research has progressed, CAR-T’s efficacy has been found to extend beyond cancer with great potential in treating autoimmunity, infections, fibrosis, aging-related diseases and more.

The results suggest that genetic variants in AVPR1A RS3-RS1 haplotypes may affect verbal learning and memory performance in part by modulating the left hippocampal CA2/3 structure and its rsFC with the thalamus.

Proliferating Cell Nuclear Antigen (PCNA) is a protein present in all eukaryotic cells that plays a crucial role in DNA synthesis and repair.

These findings suggest that Puma inhibitors may have therapeutic potential for the treatment of these disorders.