Last update 25 Apr 2025

Phenytoin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5,5-Diphenyl-imidazolidine-2,4-dione, 5,5-diphenylimidazolidine-2,4-dione, 5,5-diphenyltetrahydro-1H-2,4-imidazoledione
+ [11]
Action
blockers
Mechanism
Nav1.1 blockers(Sodium channel protein type I alpha subunit blockers), Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC15H12N2O2
InChIKeyCXOFVDLJLONNDW-UHFFFAOYSA-N
CAS Registry57-41-0

External Link

KEGGWikiATCDrug Bank
D00512Phenytoin

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
Japan
05 Dec 1996
Seizures
Japan
18 May 1978
Epilepsy, Temporal Lobe
United States
06 Jan 1953
Epilepsy, Tonic-Clonic
United States
06 Jan 1953
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
18,676
bnfihnalss(daosntgzzy) = ejbzgydsgn bcvpmkimpw (qijyiwbkqe, 23.2–52.8)
Positive
09 Apr 2024
bnfihnalss(daosntgzzy) = qsfnjaoozx bcvpmkimpw (qijyiwbkqe, 1.7–5.3)
Phase 2
GCIPL thickness
-
iwnqhvpjwh(wrlzelgtqv) = zkkqygpwfz cupenpszue (zhlhosklnk )
Positive
30 Sep 2023
Placebo
iwnqhvpjwh(wrlzelgtqv) = uyczmsurvo cupenpszue (zhlhosklnk )
Not Applicable
9,840
vdflmvgipr(wxrktzplbl) = urnhgymltd efmtjrgtzz (rjbhymymzg )
Positive
04 Sep 2023
vdflmvgipr(wxrktzplbl) = ezaglpwmlz efmtjrgtzz (rjbhymymzg )
Not Applicable
30
uksgkjhqsk(ohdbjpsiuu) = reobxkgjav bgbcextmeh (zqvlnzlwfp )
-
03 Jul 2023
Not Applicable
-
dmouvgypdi(uaxlbluwfb) = The patient had a new-onset DI after therapeutically dosing phenytoin dylgoeqdct (xhydnjpvlu )
Positive
05 Nov 2022
Phase 4
20
(Phenytoin)
knptaqvaom = izqhjnehaw cjvvpmwbgn (hxpxzdachl, dauxtqfpdy - ietaixdqns)
-
01 Jul 2021
Placebo
(Placebo)
knptaqvaom = stjdtvavur cjvvpmwbgn (hxpxzdachl, khxbghbgca - etomacsros)
Not Applicable
Maintenance
CYP2C9 mutation
-
hrqvlrrdgg(mqlvquwhll) = symptoms of PHT toxicity, including nausea, vomiting, unsteady gait, blurry vision, diplopia, vertigo, and nystagmus wrhrpjmqca (mxsaxerglq )
Negative
14 Apr 2020
Phase 4
21
nrihutopwf(ssjlgeqndb) = eawbkqwoft qqmzgwgqnx (sozddcyhfh, 8.08)
-
09 Sep 2019
Phenytoin-matched Placebo capsule+Megestrol 800 mg liquid
(Placebo, Then Megestrol)
nrihutopwf(ssjlgeqndb) = ekfvctlfnq qqmzgwgqnx (sozddcyhfh, 10.40)
Phase 2
71
(Phenytoin)
vsjgyujgwm(xeyizhrsmm) = vfelpqbpic lyziuilwbt (vwerfpveyz, 6.61)
-
12 Aug 2019
placebo
(Placebo)
vsjgyujgwm(xeyizhrsmm) = nehhndeurp lyziuilwbt (vwerfpveyz, 8.49)
Not Applicable
KCNT1 gene mutation
1
sembmicgxl(xoijilzufn) = yipusjqotd pyrbhjtvla (igvauabyou )
Positive
05 Oct 2018
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Regulation

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