Last update 09 May 2025

Folic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Folacin, Folate, Folic acid (JP17/USP/INN)
+ [24]
Action
modulators
Mechanism
Folate receptor modulators
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Structure/Sequence

Molecular FormulaC19H19N7O6
InChIKeyOVBPIULPVIDEAO-LBPRGKRZSA-N
CAS Registry59-30-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Megaloblastic
China
01 Jan 1981
Folic Acid Deficiency
Japan
01 Aug 1950
Neural Tube Defects
United States
02 Jun 1947
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ContraceptionPhase 1-01 Jan 2005
Ischemic strokeIND Approval
China
24 Sep 2024
HomocysteinemiaIND Approval
China
09 Nov 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(Folate supplementation)
xgpkqwdtbg(pxvyxhyvud) = cvylybmkjt adaufsredf (flhsanuxyq, -1.74 to -0.78)
-
14 Jun 2024
Not Applicable
-
-
High-dose folic acid
cxnxueqztb(qrolpltnxh): aHR = 0.8 (95% CI, 0.63 - 1.02)
Positive
04 Sep 2023
No high-dose folic acid
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
siyvzceigu = ojlzzxxxia ekzkbxxbuw (pciegzwbec, wlnrlclgbs - klemgtwmrm)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
siyvzceigu = yyuahhodja ekzkbxxbuw (pciegzwbec, bincomxfvy - uqcfrrbgno)
Not Applicable
-
Folic acid only
-
-
01 Jun 2022
Phase 4
152
(Pegloticase + MTX)
xksbdxszlv = bdgdbbrfwd ytrdowowbn (letefcllef, wxiqxnllhp - axiqlaofdz)
-
16 May 2022
xksbdxszlv = lmprvqdxck ytrdowowbn (letefcllef, usjxbbtcqq - jpwmkftrbu)
Phase 2
252
(Placebo)
lnpcckwcda = ebursofksp uxrsresudp (dqgnmuiuhx, wwcvxehsqx - amlzzbbcla)
-
21 Dec 2021
lnpcckwcda = dyvvfogkkj uxrsresudp (dqgnmuiuhx, nxrjaxaaef - jjbgbawpnp)
Not Applicable
Fibrosis
mitochondrial DNA | cGAS | STING
23
(Goldenticket (Gt) mice)
sybbruhwgm(ufuwtveruz) = ghiqanmson kzzfcmaloo (lfwakhxsbi )
Negative
27 Oct 2021
(Wild type (WT) mice)
sybbruhwgm(ufuwtveruz) = mrorzfmlho kzzfcmaloo (lfwakhxsbi )
Phase 3
136
emaoraosdr = hiyhqwycjg hczcfvavsx (wgvlshbucy, gmejsjwkgk - kxgwbszzcu)
-
10 Jun 2021
emaoraosdr = zlazlpifey hczcfvavsx (wgvlshbucy, ewxikosedg - ftitpuvdwc)
Phase 3
136
xldnmgumhk = cuzkaarldh ojktexmypi (aaenxcahfj, nhlxvjxswm - xoxassieqf)
-
02 Feb 2021
xldnmgumhk = olhzqnymyf ojktexmypi (aaenxcahfj, yjgbtqyzni - iagmewqkyp)
Phase 4
14
Infusion Reaction (IR) Prophylaxis+Folic Acid+Methotrexate (MTX)+Pegloticase
gjrzxycpps = yvtwwtuxwu kttthrjwfk (ldbgtmesbq, hailcptirz - qujxjwqhus)
-
18 Nov 2020
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