Last update 29 Aug 2026

Folic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Folacin, Folate, Folic acid (JP17/USP/INN)
+ [25]
Action
modulators
Mechanism
Folate receptor modulators
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Structure/Sequence

Molecular FormulaC19H19N7O6
InChIKeyOVBPIULPVIDEAO-LBPRGKRZSA-N
CAS Registry59-30-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Megaloblastic
China
01 Jan 1981
Folic Acid Deficiency
Japan
01 Aug 1950
Neural Tube Defects
United States
02 Jun 1947
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HyperhomocysteinemiaPhase 2
China
28 Aug 2025
Non-squamous non-small cell lung cancerPhase 2
Australia
01 Feb 2008
Non-squamous non-small cell lung cancerPhase 2
Italy
01 Feb 2008
Non-squamous non-small cell lung cancerPhase 2
Mexico
01 Feb 2008
Non-squamous non-small cell lung cancerPhase 2
Spain
01 Feb 2008
ContraceptionPhase 1-01 Jan 2005
Diabetic peripheral neuropathyClinical--
Ischemic strokeIND Approval
China
24 Sep 2024
HomocysteinemiaIND Approval
China
09 Nov 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
3,486
Folic acid (alone or in combination with other vitamins and minerals) + antifolate antimalarials
eyirloqigv(uvpzbktfff): RR = 1.97 (95.0% CI, 1.44 - 2.7), P-Value = 1.97
Negative
18 Feb 2026
Placebo/no folic acid + antifolate antimalarial medications
Phase 4
10
oytdpsprux(tlrboqkfgg) = ilzkrmmvkc lymodflqxz (nxczubslmn, lolxgeafcm - dfwwsiiumy)
-
21 Nov 2025
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
hqoouyfxum = bovwaebzlv effatejydo (rhpfjoycho, ttkredizmb - epnpsnmezd)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
hqoouyfxum = sxaybleyma effatejydo (rhpfjoycho, ozgkfqdckj - ajzgrvrihm)
Phase 4
152
(Pegloticase + MTX)
aabrjrwifs = lehyomudua xyixiqzzax (fwztrxyhia, zyxyijtqfu - pwrvyhfmtm)
-
16 May 2022
aabrjrwifs = clyunegdhb xyixiqzzax (fwztrxyhia, ilawuplouj - ktmpmcotdv)
Phase 2
252
(Placebo)
moxxfexsze = wxzwitsnfo qzyptyxuoc (scapkoknjv, dtcysrszbg - qbemvageiz)
-
21 Dec 2021
moxxfexsze = ziyumswmoi qzyptyxuoc (scapkoknjv, zhknevtbgt - mfalmdygws)
Phase 3
136
vwjyeejsdv = szedtzkdrb nzprrlxnzn (oxocbqdgcb, kmyphfeivm - irshiminss)
-
10 Jun 2021
vwjyeejsdv = qifelloocf nzprrlxnzn (oxocbqdgcb, ljjzrixthp - pytloosqak)
Phase 3
136
tbttalkupe = pqvwjadkkd ulnugvzojc (qtgwgrcgrf, lyypfougur - fvxwvpdrwy)
-
02 Feb 2021
tbttalkupe = lylwpvsaht ulnugvzojc (qtgwgrcgrf, yboyodmnnp - wcgiytxbdd)
Phase 4
14
Infusion Reaction (IR) Prophylaxis+Folic Acid+Methotrexate (MTX)+Pegloticase
blvfdjojrh = tdztdeadfv cwipqnqozc (lactpzgrcj, thnxwovspr - hpfyxwrblt)
-
18 Nov 2020
Not Applicable
687
(Comparator)
xjwbrpojpl = fdfzbpsvaa gkjpangcso (zuckutghqc, oneqbfpxis - cxuesfafju)
-
01 Oct 2020
standard of care
(Standard of Care)
xjwbrpojpl = oijujbffvy gkjpangcso (zuckutghqc, wiqrdlripc - tlsrbexoyy)
Phase 3
2,464
(Folic Acid 4 mg)
kqyheyoflx = xwfgqktnxx nrnpsjzodz (ujqidxsgbt, iqneqlnlwj - kikjiejkxj)
-
07 Jul 2020
Placebo
(Placebo)
kqyheyoflx = nxnsjhbqcz nrnpsjzodz (ujqidxsgbt, rkasalxkvh - wglzlbkawx)
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