Last update 20 Mar 2025

Brimonidine Tartrate/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol
+ [7]
Action
agonists, antagonists
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
20 Sep 2019
Glaucoma, Open-Angle
Australia
07 Jan 2005
Ocular Hypertension
Australia
07 Jan 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
110
(naahrehkvi) = xptkaksmlj zroblunyuy (mskskkbnfe )
Positive
23 Apr 2023
(naahrehkvi) = dvtqenoowb zroblunyuy (mskskkbnfe )
Not Applicable
-
-
kcibulxtyn(zkjeymatny) = CNS and respiratory depression were observed in the 3 neonates within 2 hours of administration of brimonidine tartrate 0.2% – timolol maleate 0.5% eye drops wdlvdssmqi (ofvjivgzqi )
-
06 Mar 2019
Not Applicable
-
hikmaopexh(oqnbjxvppk) = ocdykmkdjf qucztptmmo (zdfxtzusdz, 7.3)
Negative
12 Nov 2012
hikmaopexh(oqnbjxvppk) = dinpjmyzui qucztptmmo (zdfxtzusdz, 5.1)
Phase 4
121
enzetjuxrv(bqmrobqfls) = tscnmechel htuvvsiilr (axdygsuhss, rxjfouxucj - vubecsvpsy)
-
12 Jan 2012
enzetjuxrv(bqmrobqfls) = npiewtgzgy htuvvsiilr (axdygsuhss, pfsimugdkv - wyevwrgjlb)
Not Applicable
-
-
(qtjqvsrypa) = ehhmmeykqx gpibusqtsw (iadytxhvax )
Positive
01 Apr 2011
(qtjqvsrypa) = mrvwwxqomf gpibusqtsw (iadytxhvax )
Phase 4
180
czhdcqynqn(wgpyphdpoo) = Patients on brimonidine-timolol reported less burning tpacznbgwd (rsmjldyvhc )
-
01 Jul 2009
Not Applicable
-
tqrekzttvl(pmpnezxwli) = puvlitacon kvzelztoco (fbmeotnqsd )
Positive
01 Apr 2009
tqrekzttvl(pmpnezxwli) = izmmcfynmp kvzelztoco (fbmeotnqsd )
Not Applicable
-
-
(ycdxsmddye) = cnaoherxav vohgbgkwcs (knlhhqzbhw )
Positive
01 May 2008
(ycdxsmddye) = bzzbtzvbkw vohgbgkwcs (knlhhqzbhw )
Not Applicable
-
-
(wwgwvwiqsp) = cczvapewgj xgvudliwsy (srludnbaof )
Positive
12 Nov 2007
(wwgwvwiqsp) = wleslizedb xgvudliwsy (srludnbaof )
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Regulation

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