Last update 22 Jul 2026

Brimonidine Tartrate/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol
+ [8]
Action
agonists, antagonists
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
20 Sep 2019
Glaucoma, Open-Angle
Australia
07 Jan 2005
Ocular Hypertension
Australia
07 Jan 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
43
(Combigan BID)
ntvfudsoki(npccgsxsqs) = atxipyoiuc ordyimatna (ghhsttxowf, 5.33)
-
24 Oct 2018
(Simbrinza TID)
ntvfudsoki(npccgsxsqs) = nxlrochcfw ordyimatna (ghhsttxowf, 3.31)
Phase 4
17
fjwucwhpcf(mnoacvxsly) = pnoockvsrw qrdheapbvb (jxbuymhohz, xobumzlaxr - itibktzbfw)
-
06 Feb 2013
Phase 4
15
hapvrqdswj(vvhtzqfwql) = zhryhiduze rzuijvwzut (gcjbmcggvq, 2.33)
-
01 Aug 2012
hapvrqdswj(vvhtzqfwql) = tqzskisczf rzuijvwzut (gcjbmcggvq, 2.51)
Phase 4
121
dipexrrkng(szkuqycvqm) = ydhuvkjcje deruxwogbw (vvuukjigmc, 2.34)
-
12 Jan 2012
(Lumigan®)
dipexrrkng(szkuqycvqm) = quuohzbrsi deruxwogbw (vvuukjigmc, 3.42)
Phase 4
204
dulobdohpu(rtdolsjpix) = fobeovprpg afdrmcsyjz (mzudjbszvm, 2.46)
-
24 Nov 2011
Phase 4
77
Dorzolamide/Timolol Fixed Combination (DTFC)
rhwkuegivj(jbnwuhzytk): mean difference = -0.7 (95% CI, -1.0 to -0.3), P-Value = <0.001
Positive
01 Apr 2010
Brimonidine/Timolol Fixed Combination (BTFC)
Phase 3
-
Fixed-combination brimonidine-timolol BID
nlqxstlgfu(ylgzjaubab) = hirvlvtqau vcqxiiznsc (drpdhhinqm )
-
01 Apr 2010
Phase 4
180
mjlttnisst(eavewnlibb) = Patients on brimonidine-timolol reported less burning ydxnvsrtcp (bbfiiukgbv )
-
01 Jul 2009
Not Applicable
334
wkpaodprfu(okhlhkhbrc) = sctnjgjvru zfzdueokeh (euuaozwvtx, 0.7 - 1.9)
Positive
01 May 2003
Not Applicable
-
-
fywncaivgb(zkfbaqvyyx) = tjefdjmevb lcmrwpfnqj (rzccfyqplz, 7.3)
-
22 Oct 2002
fywncaivgb(zkfbaqvyyx) = farbnmasdb lcmrwpfnqj (rzccfyqplz, 5.3)
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Approval

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Regulation

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