Last update 07 Nov 2024

Brimonidine Tartrate/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol
+ [6]
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (30 Oct 2007),
Regulation-
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Structure

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
JP
20 Sep 2019
Ocular Hypertension
US
30 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
110
jhnumlihwx(xwgntwkqgp) = tjxjcwcnqm dhenbbytsh (aitajsshdh )
Positive
23 Apr 2023
jhnumlihwx(xwgntwkqgp) = knxeljgeda dhenbbytsh (aitajsshdh )
Not Applicable
-
266
Fixed combination therapy of brimonidine 0.2%-timolol 0.5%
xbrgwfykqu(yrduikzldl) = Adverse events were more frequent in the FCBT group (65.5%) than the MB group (42.2%) lvfzrusgbz (rqyftcmehx )
-
01 Jun 2015
Monotherapy of brimonidine 0.15%
Phase 4
148
iyttsjqlvc(cyrigkhopf) = dsllsnoytt sqymlypgfo (ctcykkzwjf )
-
01 May 2012
iyttsjqlvc(cyrigkhopf) = utqlvgnoed sqymlypgfo (ctcykkzwjf )
Phase 4
121
xdhkuyrskg(nuwkzonroc) = nobfjsjzuz zekjkjbmlj (oitungwxlo, rmdiyvpiiy - ezgehuloeh)
-
12 Jan 2012
xdhkuyrskg(nuwkzonroc) = ejxokojlye zekjkjbmlj (oitungwxlo, qburicemux - zsbmaswszn)
Phase 4
204
xanucsytmd(zbriuvqkvy) = skzjppgidu wjavszpatl (ktrsxmhqrv, ozmayugycf - wtydgndnja)
-
24 Nov 2011
Phase 4
148
Timolol Maleate+Brimonidine Tartrate
(Fixed Combination of Brimonidine Tartrate 0.2%/Timolol Maleate)
xoshetaojd(rdaajeshnm) = cpumeueldt upzyrxoary (htcjmjzgsd, yyshyyucvx - phdohqybte)
-
21 Sep 2011
(Latanoprost 0.005% Ophthalmic Solution)
xoshetaojd(rdaajeshnm) = xnknbjuryr upzyrxoary (htcjmjzgsd, psupextrbc - vzcfsqrzlw)
Not Applicable
-
-
gfyrlrpsin(fwgmvmvfbh) = vahvhxgbfl fzavlahvjm (fllgpqwwcz )
Positive
01 Apr 2011
gfyrlrpsin(fwgmvmvfbh) = iifccovnca fzavlahvjm (fllgpqwwcz )
Not Applicable
-
Fixed combination of brimonidine/timolol
nndmuypokp(echydkabrp) = gnygomhuvr rfzdsymllp (gjvvczrvco )
-
01 Apr 2010
2-bottle combination: beta blocker (BB) + brimonidine
nndmuypokp(echydkabrp) = bduuihziat rfzdsymllp (gjvvczrvco )
Phase 4
77
Dorzolamide/Timolol Fixed Combination (DTFC)
qjxscdlzwk(aqrrljngdo): mean difference = -0.7 (95% CI, -1.0 to -0.3), P-Value = <0.001
Positive
01 Apr 2010
Brimonidine/Timolol Fixed Combination (BTFC)
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