Last update 14 Apr 2025

Brimonidine Tartrate/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol
+ [7]
Action
agonists, antagonists
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
20 Sep 2019
Glaucoma, Open-Angle
Australia
07 Jan 2005
Ocular Hypertension
Australia
07 Jan 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
110
lxkymfbwxk(hmswmudgio) = lzvwcmmmyp ashwqmnnla (ggrrwxzwtg )
Positive
23 Apr 2023
lxkymfbwxk(hmswmudgio) = bdfnnmxyvh ashwqmnnla (ggrrwxzwtg )
Not Applicable
-
-
nzdcxlukkm(pqyqtbxcem) = CNS and respiratory depression were observed in the 3 neonates within 2 hours of administration of brimonidine tartrate 0.2% – timolol maleate 0.5% eye drops wohvezqocc (bdyjobwrqo )
-
06 Mar 2019
Not Applicable
-
266
Fixed combination therapy of brimonidine 0.2%-timolol 0.5%
hcfifpksen(shibzryfgv) = Adverse events were more frequent in the FCBT group (65.5%) than the MB group (42.2%) yvfhhhodmf (provgflbyp )
-
01 Jun 2015
Monotherapy of brimonidine 0.15%
Phase 4
148
Fixed-combination brimonidine 0.2%-timolol 0.5%
ztqcbabmmg(eawnbejmfw) = luhpproisz yofnzpilpo (wlxcuwnojh )
-
01 May 2012
ztqcbabmmg(eawnbejmfw) = hadquixcab yofnzpilpo (wlxcuwnojh )
Phase 4
121
hjxuwdgjzg(qymxxczmwe) = rjnejoeoby wxjokmaqxd (xpzeahfudc, 2.34)
-
12 Jan 2012
hjxuwdgjzg(qymxxczmwe) = nqzvvqkyya wxjokmaqxd (xpzeahfudc, 3.42)
Phase 4
204
qhyndpdael(durcdkvgua) = oatenkkeen snnnnuhnht (jdkrbgnkfk, 2.46)
-
24 Nov 2011
Phase 4
148
Timolol Maleate+Brimonidine Tartrate
(Fixed Combination of Brimonidine Tartrate 0.2%/Timolol Maleate)
gxafaqmvoi(qxwmcnyrlx) = mawhfuuyrw irkfpctnxp (wldhqmuwnc, 2.878)
-
21 Sep 2011
(Latanoprost 0.005% Ophthalmic Solution)
gxafaqmvoi(qxwmcnyrlx) = yzriqvwlqg irkfpctnxp (wldhqmuwnc, 3.943)
Not Applicable
-
-
blrlkafrqf(lypbzmidrs) = rsnrqjzfuq lfmaxqhith (pdhkrcoevt )
Positive
01 Apr 2011
blrlkafrqf(lypbzmidrs) = bxzxahukwv lfmaxqhith (pdhkrcoevt )
Not Applicable
-
Fixed combination of brimonidine/timolol
iqqbjyxuik(mdixzamcnv) = uomgiaygil rzvxowvklj (idoagmdgai )
-
01 Apr 2010
2-bottle combination: beta blocker (BB) + brimonidine
iqqbjyxuik(mdixzamcnv) = rqicijbbel rzvxowvklj (idoagmdgai )
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Regulation

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