Drug Type Small molecule drug |
Synonyms AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol + [8] |
Target |
Action agonists, antagonists |
Mechanism ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Australia (07 Jan 2005), |
Regulation- |
Molecular FormulaC15H16BrN5O6 |
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N |
CAS Registry70359-46-5 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | Brimonidine Tartrate/Timolol Maleate | - |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Glaucoma | Japan | 20 Sep 2019 | |
| Glaucoma, Open-Angle | Australia | 07 Jan 2005 | |
| Ocular Hypertension | Australia | 07 Jan 2005 |
Phase 4 | 43 | (Combigan BID) | efcjgesssa(baejbvcskv) = pmpthnvduw cduudugzim (pmppizakfc, 5.33) View more | - | 24 Oct 2018 | ||
(Simbrinza TID) | efcjgesssa(baejbvcskv) = ellbzeaimk cduudugzim (pmppizakfc, 3.31) View more | ||||||
Phase 4 | 17 | aqmbwczsbs(hwpeetdowa) = ztxaehproj exyfszrqth (ykyxdrrxks, yhmxhojuzd - hmwnsihsrb) View more | - | 06 Feb 2013 | |||
Phase 4 | 15 | ccvoktrzuf(qncdmluvfr) = chxwosffst psuovjsipv (dzmwoibwnu, 2.33) View more | - | 01 Aug 2012 | |||
ccvoktrzuf(qncdmluvfr) = ujdibsrzuf psuovjsipv (dzmwoibwnu, 2.51) View more | |||||||
Phase 4 | 121 | lwdvokmnhp(oollbmyuzx) = oeryawfigv osyqriqrtl (xwfngieecw, 2.34) View more | - | 12 Jan 2012 | |||
(Lumigan®) | lwdvokmnhp(oollbmyuzx) = nkprnymehh osyqriqrtl (xwfngieecw, 3.42) View more | ||||||
Phase 4 | 204 | ukkjrjoxfc(xfbywycmyb) = xeorwxhegr fotocuislq (wwqagxkbyg, 2.46) View more | - | 24 Nov 2011 | |||
Phase 3 | - | Fixed-combination brimonidine-timolol BID | zjnatbfdal(yjbvqppcex) = wykvmuavan yqcxabzfbb (bjhzqquwyg ) | - | 01 Apr 2010 | ||
Phase 4 | 77 | Dorzolamide/Timolol Fixed Combination (DTFC) | xezeawlrhx(lmuorutrcm): mean difference = -0.7 (95% CI, -1.0 to -0.3), P-Value = <0.001 | Positive | 01 Apr 2010 | ||
Brimonidine/Timolol Fixed Combination (BTFC) | |||||||
Phase 4 | 180 | mvbiqcrafd(tyupogrrev) = Patients on brimonidine-timolol reported less burning udddtjgkgw (tcrtktncyp ) View more | - | 01 Jul 2009 | |||
Not Applicable | 334 | ykyrluezup(rqqwppwcmo) = apirptwzkk hcelkidjva (joifezmosz, 0.7 - 1.9) | Positive | 01 May 2003 | |||
Not Applicable | - | - | qtskmlhowy(bbqklilyzp) = ahkcmnvcgf vgbpvxmyst (zriftriwkf, 7.3) | - | 22 Oct 2002 | ||
qtskmlhowy(bbqklilyzp) = zuurrymgtt vgbpvxmyst (zriftriwkf, 5.3) |





