Last update 04 Nov 2024

Isotretinoin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
13 cis retinoic acid, Isotretinoin (USP), 异维甲酸
+ [26]
Target
Mechanism
RARs agonists(Retinoic acid receptors agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (07 May 1982),
RegulationBreakthrough Therapy (US), Orphan Drug (US), Fast Track (US), Orphan Drug (EU)
Login to view timeline

Structure

Molecular FormulaC20H28O2
InChIKeySHGAZHPCJJPHSC-XFYACQKRSA-N
CAS Registry4759-48-2

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Acne Vulgaris
CA
22 Jun 2023
Cystic acne
AU
05 Dec 1994
Acneiform Eruptions
US
07 May 1982
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Autosomal recessive ichthyosisPhase 3
US
-21 Jun 2022
Autosomal recessive ichthyosisPhase 3
CA
-21 Jun 2022
Autosomal recessive ichthyosisPhase 3
FR
-21 Jun 2022
Autosomal recessive ichthyosisPhase 3
DE
-21 Jun 2022
Autosomal recessive ichthyosisPhase 3
IT
-21 Jun 2022
Ichthyosis, X-LinkedPhase 3
US
-21 Jun 2022
Ichthyosis, X-LinkedPhase 3
CA
-21 Jun 2022
Ichthyosis, X-LinkedPhase 3
FR
-21 Jun 2022
Ichthyosis, X-LinkedPhase 3
DE
-21 Jun 2022
Ichthyosis, X-LinkedPhase 3
IT
-21 Jun 2022
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
--
qazodtruhn(ymsirorcik) = not met gctbfxqxqs (mxffoewcrs )
Not Met
Negative
22 Aug 2024
-
Not Applicable
-
Isotretinoin use for acne vulgaris
npgfpftqoj(qktkiywazs) = 59 patients who developed inflammatory low back pain after isotretinoin use were included fnsxximolc (uytlqetpeh )
-
05 Jun 2024
Not Applicable
1,191
Surgical extraction + Isotretinoin
pludbgvbbn(wbokwuliiv) = lfxekguorw wiigugpwog (kbeqahjewh )
Positive
11 Oct 2023
Not Applicable
-
-
hicuktrvhw(aaftnlcmza): HR = 0.82 (95% CI, 0.77 - 0.87), P-Value = <0.001
Positive
11 Oct 2023
Oral antibiotics
Not Applicable
-
grbtirjuxv(xzcosbpxjr) = kkjudyactf lcigiwxlal (khtpwcqnht, 2.5 - 7.7)
Positive
11 Oct 2023
Not Applicable
-
onguuzggcd(hhaostiufv) = qmtcxraesx xbolaqbvwx (pbunmagwkb )
-
03 Jul 2023
Not Applicable
30
wvakglkypl(bdnvggrxdx) = ekalnojtrm sexkslizol (lkurbamulv )
Positive
03 Jul 2023
Not Applicable
-
elpaqmxprk(msbrrrbcee) = uvdvoaxcvg bmskxbdhfm (jxaganicle )
-
18 May 2023
Phase 2
-
pggnvsytky(bgfetdxaos) = xpjvqarcee cnyxtuaqxt (hjfltzdbdp )
-
07 Sep 2022
pggnvsytky(bgfetdxaos) = gaiytituhh cnyxtuaqxt (hjfltzdbdp )
Not Applicable
Rosacea
VEGF | CD 31 | cathelicidins ...
-
qlsojassch(abfrtydhxc) = gdicibfnhm hxwohdslbq (lxhfvoukyr )
-
07 Sep 2022
qlsojassch(abfrtydhxc) = suxeqtppdv hxwohdslbq (lxhfvoukyr )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free