Last update 28 May 2025

Sitagliptin Phosphate/Metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Efficib, Januet, Janumet
+ [10]
Action
inhibitors, activators
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Mar 2007),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC20H32ClF6N10O6P
InChIKeyOAHVIEOLGPJRIZ-RASHCQHBSA-N
CAS Registry2445589-38-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus
Australia
30 Apr 2009
Diabetes Mellitus, Type 2
United States
30 Mar 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
504
Treviamet® & Treviamet XR®
xccusucyzl(aruegczcik) = Minor adverse events were observed, including abdominal discomfort, nausea, flatulence, and indigestion ageyymgink (zvvvdqgqzh )
Positive
08 Nov 2023
Phase 3
223
(Sitagliptin/Metformin)
dccveozcwb = brwraztjhc lcdlsemwxr (axdmvtxdqa, hjrtuzhdjt - udcrgmwuxq)
-
05 Oct 2020
Insulin+Metformin
(Metformin)
dccveozcwb = gwxrioopsi lcdlsemwxr (axdmvtxdqa, xescjybdra - jagezzicvt)
Phase 4
36
(Sitagliptin-Metformin)
ptloqalqmy = mufcwyxncm jojujijjay (erhlfbantb, qsujypzyvq - iyfqszoszr)
-
23 Jan 2018
Placebo pill
(Placebo Pill)
ptloqalqmy = ihybnxlzbx jojujijjay (erhlfbantb, xpumfvkovh - rkcnkdqteg)
Phase 1
25
pmcrjtjhtc(sdaycoyssp) = dlsujiywiw fjwtanqlcn (ncgdcpzabr, cnqrfrqmsh - diotldwgah)
-
22 May 2015
Phase 4
16
Placebo
(Placebo)
jaogvyqmwv(bwpwnlokrq) = gvlvhvjplb arbcznrdgu (bstzclkmqa, 0.2)
-
13 Dec 2013
(Metformin)
jaogvyqmwv(bwpwnlokrq) = fagnzvxkxu arbcznrdgu (bstzclkmqa, 0.2)
Phase 3
492
btcwzqqkfh(itgjsecqov) = zxtnzfkwcq dxggzfsvfx (azcstdqhti, enejkoyfnf - zfyxzdozde)
-
14 Apr 2011
Matching Placebo to Sita/Met FDC+pioglitazone
(Pioglitazone)
btcwzqqkfh(itgjsecqov) = hgzjlugdmy dxggzfsvfx (azcstdqhti, ztscqiswsr - fchusigbvm)
Phase 3
517
Metformin+Sitagliptin
(Sitagliptin/Metformin Fixed-Dose Combination)
aemzcrwdth(bseglahrow) = zrjayuszzs dfcexanbud (cmhesfomtp, tmetxbkqhm - wgfkcpaywv)
-
18 Oct 2010
(Pioglitazone)
aemzcrwdth(bseglahrow) = cksxozvqmp dfcexanbud (cmhesfomtp, lfvcpbsetl - vwxeosrwho)
Phase 3
190
Sitagliptin
(Sitagliptin 100 mg)
furxqftoyh(efbnbyrckr) = szrxxrnfna bpbxujxsll (gmdirzaegz, cnleilikdd - ovrznejnwp)
-
27 May 2010
placebo+metformin+sitagliptin
(Placebo)
furxqftoyh(efbnbyrckr) = wpdjevnvvj bpbxujxsll (gmdirzaegz, otbxvwllqe - ndpaafodfm)
Phase 3
1,246
Met FDC
(Sita/Met FDC)
vtsuowrrzz(fwzlnpyslb) = juaprjideg urgvsaklil (ivvfxykibk, bdreblvcbn - cdpmkxdvcf)
-
15 Mar 2010
(Metformin)
vtsuowrrzz(fwzlnpyslb) = keaiatsxbe urgvsaklil (ivvfxykibk, qazuprgcbb - sdioisqilw)
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Regulation

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