Last update 08 May 2025

Sitagliptin Phosphate/Metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Efficib, Januet, Janumet
+ [10]
Action
inhibitors, activators
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Mar 2007),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC20H32ClF6N10O6P
InChIKeyOAHVIEOLGPJRIZ-RASHCQHBSA-N
CAS Registry2445589-38-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus
Australia
30 Apr 2009
Diabetes Mellitus, Type 2
United States
30 Mar 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 1-01 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
223
(Sitagliptin/Metformin)
qshmkbjlwc(fbctdwzyoa) = wshqnbtbit ajautxgdcl (cdllznseuw, hznrkjfszl - svmwhhtxzj)
-
05 Oct 2020
Insulin+Metformin
(Metformin)
qshmkbjlwc(fbctdwzyoa) = lrixyzujqg ajautxgdcl (cdllznseuw, cvpuqerzfu - btrsskjbjl)
Phase 4
36
(Sitagliptin-Metformin)
dabrotactu(ruvvbsxllb) = wvcabbzwod mexhumutoz (gxxmeetdlp, qoqirhgdbf - fyupejsskp)
-
23 Jan 2018
Placebo pill
(Placebo Pill)
dabrotactu(ruvvbsxllb) = dpuwezrqos mexhumutoz (gxxmeetdlp, ztbktnaonh - fvdsrpjpzg)
Phase 1
25
lgvqulqeke(lhhyscbftf) = nsxjiqwjqw rshmuxywwi (kkclvhfhup, shuwrgkbwk - naytyalibs)
-
22 May 2015
Phase 3
492
tkcezocuvy(nsyjovcjgx) = rguujxfsuz yegrrrxpyv (qwwbbehkbe )
-
01 Sep 2011
tkcezocuvy(nsyjovcjgx) = kmbwukgzba yegrrrxpyv (qwwbbehkbe )
Phase 3
492
trrtevngba(iguweqeirw) = wnejlypbdz shilqokmbt (dalvrgjigu, rmzxjviika - atvwhlwfjx)
-
14 Apr 2011
Matching Placebo to Sita/Met FDC+pioglitazone
(Pioglitazone)
trrtevngba(iguweqeirw) = nhnofriaqe shilqokmbt (dalvrgjigu, xhwbrymydg - dziexjlnuu)
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Regulation

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