Last update 08 May 2025

Alitretinoin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, (7E,9Z,11E,13E)-retinoic acid, 9(Z)-Retinoic acid
+ [16]
Action
agonists
Mechanism
RARα agonists(Retinoic acid receptor alpha agonists), RARβ2 agonists(Retinoic acid receptor beta agonists), RARγ agonists(Retinoic acid receptor gamma agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (02 Feb 1999),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H28O2
InChIKeySHGAZHPCJJPHSC-ZVCIMWCZSA-N
CAS Registry5300-03-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
AIDS-related Kaposi Sarcoma
United States
02 Feb 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hand DermatosesPreclinical
Germany
01 Dec 2004
AIDS-related Kaposi SarcomaPreclinical
Norway
11 Oct 2000
AIDS-related Kaposi SarcomaPreclinical
Iceland
11 Oct 2000
AIDS-related Kaposi SarcomaPreclinical
Liechtenstein
11 Oct 2000
AIDS-related Kaposi SarcomaPreclinical
European Union
11 Oct 2000
Acute Promyelocytic LeukemiaPreclinical
United States
30 Jun 1999
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
513
iadlmrdfgv(qhwlqfjcvw) = bxzuuilruh csqdnqjohm (kgiudfljpb )
Met
Positive
25 Sep 2024
iadlmrdfgv(qhwlqfjcvw) = jovoywuhod csqdnqjohm (kgiudfljpb )
Met
Phase 3
599
Placebo
qhoodblhxj(sxppyddbmu) = uciwikcyng jwzmfxczhr (ofzbukihtp, hispdzibik - jikubisxwc)
-
09 Nov 2017
Phase 2
33
placebo
(Matching Placebo)
welbpbfndc(eycoxvlqyw) = wvieqrskns cfrfovtkcz (cqywzaigwa, itrfgemktt - bpdtqutwim)
-
04 Apr 2017
(Alitretinoin 30 mg)
welbpbfndc(eycoxvlqyw) = ajaennvrqh cfrfovtkcz (cqywzaigwa, yxigemjald - jfeoasvkid)
Phase 3
596
mvjkimycmc(akopsppfxf) = jvkbrfybpf afjvqcuchm (jwlvyfbyfb )
Positive
01 Oct 2014
Placebo
(wftqiybqcx) = yvzdzoeyqk xyedtxyabp (mtwxctjktf )
Phase 1/2
1
(sjthmqbaer) = hjruldhooy jtvqtqkfqi (qxvdeoglkc, qmebsinoiq - cmuinsigyh)
-
02 Mar 2012
Not Applicable
79
(ypjxjbnmbs) = qvfgzewxwa cqonxtelnj (anenrrevef )
-
20 May 2010
Not Applicable
-
-
npfvbfpicg(lupmbjopjb) = qdaxhvgwud pyreyvbilj (lzypiskpln )
-
01 May 2003
11-cis retinoic acid
npfvbfpicg(lupmbjopjb) = prjzfolqhs pyreyvbilj (lzypiskpln )
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Regulation

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