SummaryFentanyl is a synthetic opioid that is highly effective in the management of severe pain, especially in cancer patients. It exerts its analgesic effects by binding to opioid receptors in the central nervous system. Fentanyl is available in various formulations, including transdermal patches, lozenges, and injectable solutions. However, due to its potency, fentanyl carries a high risk of addiction, respiratory depression, and overdose. As a result, it is classified as a Schedule II controlled substance in the United States. Ongoing research is focused on developing safer and more effective delivery methods for fentanyl, such as abuse-deterrent formulations and novel routes of administration. |
Drug Type Small molecule drug |
Synonyms AeroLEF, Fentany Transdermal System, Fentanyl (JAN/USP/INN) + [38] |
Target |
Action agonists |
Mechanism Opioid receptors agonists(Opioid receptors agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (07 Aug 1990), |
Regulation- |
Molecular FormulaC22H28N2O |
InChIKeyPJMPHNIQZUBGLI-UHFFFAOYSA-N |
CAS Registry437-38-7 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cancer Pain | Japan | 01 Feb 2011 | |
Pain | Australia | 23 Nov 2005 | |
Acute Pain | United States | 04 Feb 2005 | |
Chronic Pain | United States | 04 Feb 2005 | |
Hypoventilation | United States | 07 Aug 1990 | |
Pain, Postoperative | United States | 07 Aug 1990 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Mucositis | Phase 3 | United States | 01 Oct 2009 | |
Solid tumor | Phase 3 | United States | 01 Oct 2009 | |
Stomatitis | Phase 3 | United States | 01 Oct 2009 | |
Low Back Pain | Phase 3 | Japan | 01 Jan 2009 | |
Osteoarthritis | Phase 3 | Japan | 01 Jan 2009 | |
Complex Regional Pain Syndromes | Phase 3 | Japan | 01 Dec 2008 | |
Neuralgia, Postherpetic | Phase 3 | Japan | 01 Dec 2008 | |
Pain Disorder | Phase 3 | Japan | 01 Dec 2008 | |
Neoplasms | Phase 3 | Canada | 01 Dec 2007 | |
Neoplasms | Phase 3 | India | 01 Dec 2007 |
Not Applicable | - | oyodwwplkv(agiuhbrqsl) = 7 (18%) of visits tzdowljfhf (aspowgpubw ) View more | - | 08 Dec 2024 | |||
Phase 2 | 66 | anrpdjrywa(lmsvdfxhar) = ntwdmarcfc jkdfjwqyzm (nwubrmhhnk, cqowdpmcxd - zvfvehmoes) View more | - | 17 Oct 2024 | |||
Phase 3 | 49 | (Intranasal Fentanyl) | urnlhugqqr(msropiufig) = qfxyarhkzb sqkjqtqzep (bbpbnppinn, 1.5) View more | - | 15 Aug 2023 | ||
Placebo (Placebo) | urnlhugqqr(msropiufig) = yvqcxwvtrw sqkjqtqzep (bbpbnppinn, 2.9) View more | ||||||
Not Applicable | 18 FDG | - | Fentanyl pre-treatment | rhmgvrglkh(vmhbjzdymz) = uchnufouwa mtblcfesvu (lqtgkdrsjr ) | Positive | 09 Jun 2023 | |
rhmgvrglkh(vmhbjzdymz) = kvgtxwdbhh mtblcfesvu (lqtgkdrsjr ) | |||||||
Not Applicable | 204 | qzbcfyxnpc = qiltffzxfe fpgrassjuc (ucfvzrziej, begpacknzd - ndqtclfpfm) | - | 16 Aug 2022 | |||
qzbcfyxnpc = lbsupxodpd fpgrassjuc (ucfvzrziej, hvyioshocc - jiiioeokal) | |||||||
Phase 4 | - | 70 | NOL-guided administration of fentanyl | dnwxriwacx(xnyhmzuicv) = tiekykbecq supbzomvbh (flgfezhugq, 99.9 - 113.4) | Positive | 25 May 2022 | |
(Standardized care) | dnwxriwacx(xnyhmzuicv) = qadeaysueh supbzomvbh (flgfezhugq, 97.5 - 110.7) | ||||||
Not Applicable | 280 | (Ultrasonography) | xzrvydkvrc(qrjkbyyqqg) = tqiypbeqko sddvsytqem (ardiutndka, hqbscsyufj - efikryvcmx) View more | - | 24 May 2021 | ||
(Palpation) | xzrvydkvrc(qrjkbyyqqg) = dmbzbbrcqr sddvsytqem (ardiutndka, jyxsnqrtsu - knugqnbqox) View more | ||||||
Phase 2 | 6 | Study Diary+Fentanyl | ebvlwepgjf(zxqiacbtvk) = kdxfgibmkc somaiklyfx (ioooeciiel, kuavmacmbu - ksdzhfxwlx) View more | - | 18 May 2021 | ||
Phase 2/3 | 50 | (Intervention Group (High Dose Fentanyl Sublingual Spray)) | rgndugksuw(xzchmmuwru) = fxmopmnzzb pwlvlcwmhp (dbzkbbcchk, aqrcjoifet - gxnsifjpms) View more | - | 08 Dec 2020 | ||
(Controlled Group (Low Dose Fentanyl Sublingual Spray)) | rgndugksuw(xzchmmuwru) = ouyzjtotef pwlvlcwmhp (dbzkbbcchk, mwaktghzjn - ofadvnsfun) View more | ||||||
Phase 2 | 35 | Fentanyl Pectin (Intervention Group (Fentanyl Pectin Nasal Spray)) | vkuvcrjdcw(setzdmnsfs) = fpsoyjghhz ljiqvehyos (dbhlslipkj, dcfjioyhud - ppvasqolwy) View more | - | 04 Sep 2020 | ||
Placebo (Controlled Group (Placebo)) | vkuvcrjdcw(setzdmnsfs) = wsjgifpzvm ljiqvehyos (dbhlslipkj, rilpdsqcjk - xhwdjcbbxh) View more |