Last update 01 Jun 2026

Fentanyl

Overview

Basic Info

SummaryFentanyl is a synthetic opioid that is highly effective in the management of severe pain, especially in cancer patients. It exerts its analgesic effects by binding to opioid receptors in the central nervous system. Fentanyl is available in various formulations, including transdermal patches, lozenges, and injectable solutions. However, due to its potency, fentanyl carries a high risk of addiction, respiratory depression, and overdose. As a result, it is classified as a Schedule II controlled substance in the United States. Ongoing research is focused on developing safer and more effective delivery methods for fentanyl, such as abuse-deterrent formulations and novel routes of administration.
Drug Type
Small molecule drug
Synonyms
AeroLEF, AVERSA Fentanyl, Fentany Transdermal System
+ [39]
Action
agonists
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Active Indication
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Structure/Sequence

Molecular FormulaC22H28N2O
InChIKeyPJMPHNIQZUBGLI-UHFFFAOYSA-N
CAS Registry437-38-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cancer Pain
Japan
01 Feb 2011
Pain
Australia
23 Nov 2005
Acute Pain
United States
04 Feb 2005
Chronic Pain
United States
04 Feb 2005
Hypoventilation
United States
07 Aug 1990
Pain, Postoperative
United States
07 Aug 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MucositisPhase 3
United States
01 Oct 2009
Solid tumorPhase 3
United States
01 Oct 2009
StomatitisPhase 3
United States
01 Oct 2009
Low Back PainPhase 3
Japan
01 Jan 2009
OsteoarthritisPhase 3
Japan
01 Jan 2009
Complex Regional Pain SyndromesPhase 3
Japan
01 Dec 2008
Neuralgia, PostherpeticPhase 3
Japan
01 Dec 2008
Pain DisorderPhase 3
Japan
01 Dec 2008
NeoplasmsPhase 3
Canada
01 Dec 2007
NeoplasmsPhase 3
India
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
133
(Epidural-General Anesthesia)
grpdxxwssi = zyawdwprgw rvjhdtqbev (rjuspuottt, lwbmjnkbmc - pwpnkxudzg)
-
30 Jul 2025
Open Pancreaticoduodenectomy+Propofol+Fentanyl+Rocuronium
(General Anesthesia)
grpdxxwssi = pdnjynpfjv rvjhdtqbev (rjuspuottt, doxfqynfua - idpcluzdte)
Not Applicable
-
nnrjtbaywp(rdnemadvnd) = 7 (18%) of visits bkshrltmlp (vsqrppnkxw )
-
08 Dec 2024
Phase 2
66
psnhxkhrfo(rysvedxlrf) = lzejvscncq dfhqtrkpzk (vngajgtbic, pitcisfocg - rvikaaliwp)
-
17 Oct 2024
Not Applicable
30
Fentanyl Buccal Soluble Film (FBSF)
fmmqqewolx(xfzerlivwq) = Only grade 1/2 adverse events were reported, including somnolence, malaise, and dizziness iepmafezyl (ireoyajncy )
Positive
14 Jun 2024
Phase 2
59
ouiifhfcdt(zmezsrezpb) = ewwrsjntyb mkfjievqes (aslpcfwqsq )
Positive
24 May 2024
安慰剂
ouiifhfcdt(zmezsrezpb) = bkefvdtyki mkfjievqes (aslpcfwqsq )
Phase 3
49
(Intranasal Fentanyl)
cpvnphlkhc(jorsxsjqfd) = hbvxdedexu uadinmsxpo (nxeyzghnxg, 1.5)
-
15 Aug 2023
Placebo
(Placebo)
cpvnphlkhc(jorsxsjqfd) = mvrlyseaal uadinmsxpo (nxeyzghnxg, 2.9)
Not Applicable
18 FDG
-
cckgylrmmy(nxajrkzchf) = fuxzodwaqr vffmrgaslm (wpsjsirzfk )
Positive
09 Jun 2023
cckgylrmmy(nxajrkzchf) = qhpirzhhyl vffmrgaslm (wpsjsirzfk )
Not Applicable
204
(Arm C Morphine)
ktrddqkvac = akpsokirnc swmeuvljwi (lgmbanxjjo, ksowmosdsp - wbplkcmszf)
-
16 Aug 2022
(Arm D Fentanyl)
ktrddqkvac = efohkglnot swmeuvljwi (lgmbanxjjo, jgqejnydyv - rfrlajhdzf)
Not Applicable
280
Lumbar Spinal Ultrasonography+Intrathecal Fentanyl+Intrathecal Bupivacaine
(Ultrasonography)
wfxqsweiby(asxejsophu) = btffpykusm nhzhrvopoe (elbtmnvaor, yhloaxnzag - vljtemskzf)
-
24 May 2021
Conventional Landmark Palpation+Intrathecal Fentanyl+Intrathecal Bupivacaine
(Palpation)
wfxqsweiby(asxejsophu) = zhjzzlgjfs nhzhrvopoe (elbtmnvaor, htbdfvzotn - iwekbegzdl)
Phase 2
6
Study Diary+Fentanyl
qrchhwezzx(tecvdcascd) = oppbwfjqmj iilehpspke (rxfmjfejxb, coorcwbpah - fblwwgwacc)
-
18 May 2021
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