Last update 25 Apr 2025

Hydromorphone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Hydromorphone, Hydromorphone HCl, 氢化吗啡酮
+ [26]
Action
agonists
Mechanism
μ opioid receptor agonists(Mu opioid receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (11 Jan 1984),
Regulation-
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Structure/Sequence

Molecular FormulaC17H20ClNO3
InChIKeyXHILEZUETWRSHC-NRGUFEMZSA-N
CAS Registry71-68-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Severe pain
United States
14 Dec 2023
Cancer Pain
Japan
01 Jun 2017
Pain, Postoperative
United States
01 Mar 2010
Pain
United States
11 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Arthritis PainPhase 3-01 Feb 2008
Low Back PainPhase 3-13 Dec 2006
Chronic osteoarthritisPhase 3-14 Nov 2006
Chronic PainPhase 3
United States
01 Jul 2005
Osteoarthritis, HipPhase 3-01 Nov 2003
Osteoarthritis, KneePhase 3-01 Nov 2003
AnesthesiaPhase 3--
AnalgesiaPhase 2-14 Dec 2006
NeoplasmsPhase 1
China
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
160
ffyphfzcyu(kkgcemfmmo) = sydgkyxmjp xfyhneeljs (duvyiaurxg, fcvkbwqcuq - epzsucxdob)
-
10 Feb 2025
(Rectus Sheath Block)
ffyphfzcyu(kkgcemfmmo) = ygycemplds xfyhneeljs (duvyiaurxg, ibxiwfnlbi - udiambxgyf)
Early Phase 1
189
(Hydromorphone)
ryesitbitn = tiikkdnzuz ewzxdansfo (pgwauhwlcj, gjqzkwnssl - rtnubyvutn)
-
18 Dec 2024
(Fentanyl)
ryesitbitn = qlsgjlaqve ewzxdansfo (pgwauhwlcj, wednozzdyz - tqtuwjwhig)
Phase 2
66
sewjkjgaem(pwkwcfxjle) = zdqcdfagio acbtwsyveg (pcwjsyuecq, tokgoavgzo - yxpxcmazjk)
-
17 Oct 2024
Phase 4
105
Laparotomy
(Arm I (Laparotomy, Liposomal Bupivacaine))
jvynahkbvf(rhdsytsssm) = hpwaimyfqk mmofwcczid (wgdwpvizbu, gbbiyvupsk - jbkrnebmtm)
-
16 Oct 2024
Laparotomy+Hydromorphone
(Arm II (Laparotomy, Liposomal Bupivacaine, Hydromorphone))
jvynahkbvf(rhdsytsssm) = bqteuzbdxu mmofwcczid (wgdwpvizbu, cbarkzujxa - xvglmbnvcm)
Phase 4
-
73
Hydromorphone 2 mg
fivkcnpdmv(uxzsiseoxr) = lfccrjpzsu ncmoznslcb (wnwiqdrqjt, 2.4)
Negative
01 Jun 2024
Placebo
fivkcnpdmv(uxzsiseoxr) = glrlqlmyca ncmoznslcb (wnwiqdrqjt, 2.3)
Phase 4
-
IV hydromorphone 1mg over 15 minutes
cwikwrkqip(njhyaphphz) = Drowsiness was more frequent in the standard group than the experimental group (50% vs 29% at 15 minutes, and 52% vs 31% at 60 minutes) ozuhxytagu (npsrmlrznh )
Positive
24 May 2024
IV hydromorphone 1mg over 2 minutes
Not Applicable
402
(Morphine)
ikpprydfju = pmqgtnnbab xzwjrjulwi (aagmgagbja, zzbhdmpavy - eoqdkktnmz)
-
11 Dec 2023
(Hydromorphone)
ikpprydfju = unmwpqvctl xzwjrjulwi (aagmgagbja, mzvthjghgx - vvpoemqwye)
Phase 3
68
ekaexyyumq(hihdsimfwb) = ohllicsohp wodgdvlmtp (yswchgwhei, xplkbxsmwu - qumeinjcyy)
-
01 Aug 2023
(Historical Control)
ekaexyyumq(hihdsimfwb) = vzamvjtpsh wodgdvlmtp (yswchgwhei, ihrukrnqxp - wnjivkciar)
Phase 3
328
Patient-Specific Protocol+Hydromorphone+Morphine
(Patient-Specific Protocol)
rxqrpfshxz(pqofnvpmlk) = nekjpehyzx ltityussla (ctajeaddds, 27.54)
-
03 Jul 2023
Weight-based Protocol+Hydromorphone+Morphine
(Weight-based Protocol)
rxqrpfshxz(pqofnvpmlk) = byvonhrowf ltityussla (ctajeaddds, 28.13)
Not Applicable
MOTS-c peptide
-
MOTS-c peptide in H2O
dajifrbkwt(dqgvupcbzx) = muxwhcmrgr zjzsowjldb (znnuisrtjf )
-
01 Jun 2022
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