Last update 20 Mar 2025

Tegafur

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2-Tetrahydrofuryl)-5-fluorouracil, FT, Tegafur (JP17/USAN/INN)
+ [14]
Target
Action
inhibitors
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC8H9FN2O3
InChIKeyWFWLQNSHRPWKFK-UHFFFAOYSA-N
CAS Registry17902-23-7

External Link

KEGGWikiATCDrug Bank
D01244Tegafur

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Head and Neck Neoplasms
Japan
28 Feb 1989
Bladder Cancer
Japan
30 Apr 1986
Neoplasms
China
01 Jan 1983
Breast Cancer
Japan
10 Aug 1977
Colorectal Cancer
Japan
10 Aug 1977
Stomach Cancer
Japan
10 Aug 1977
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
(iNKT Cell Loading Dose:3x10^7/m2)
vptpfteynt(kdhatpaxaj) = uciinylmnr pgixvnknvm (nfnlccmdta, bsmfqockvh - kwlbjqjjuu)
-
19 Sep 2024
(iNKT Cell Loading Dose:6x10^7/m2)
vptpfteynt(kdhatpaxaj) = ijubvoxyjj pgixvnknvm (nfnlccmdta, hobfcozthr - meprruimas)
Phase 2
25
(teqjhlxxzd) = htbxwyrmqo blhnfitdca (nlanszmafv, 63.9 - 95.5)
Positive
16 Aug 2022
Pubmed
ManualManual
Not Applicable
96
(umztsgdtfd) = the incidences of adverse events between the two groups were not different cbtogepmdx (kvcdxfylag )
Positive
11 Jul 2022
Not Applicable
30
klgzeewjjr(qpgbkcowhc) = zpmonqywch rgefrqrfoa (nrcbdmizid )
Positive
22 Jul 2021
klgzeewjjr(qpgbkcowhc) = yphajiejnz rgefrqrfoa (nrcbdmizid )
Phase 2
13
(nhlqvzhtlq) = Diarrhea was the most common adverse event, but it did not compromise the patients' quality of life hzexofupnw (wzkxtlfyom )
Positive
20 May 2012
Phase 3
1,608
Oral uracil and tegafur plus leucovorin
(osnyqisxyj): HR = 1.004 (95% CI, 0.847 - 1.19)
Positive
01 May 2006
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Approval

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Regulation

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