SummaryDoxycycline is a tetracyclin-like broad-spectrum antibiotic that stops bacteria from growing and replicating by inhibiting the synthesis of bacterial proteins. Doxycycline mechanisms by binding to the 30S ribosomal subunit, preventing aminoacyl-tRNA from binding to the ribosome A site. This hinders the production of proteins and ultimately leads to the death of bacterial cells. Doxycycline is widely used to treat respiratory infections, urinary tract infections and sexually transmitted infections caused by bacteria. Its effectiveness, versatility and low cost make it a valuable tool in the fight against infectious diseases. |
Drug Type Small molecule drug |
Synonyms Doxycycline, Doxycycline (USP), Doxycycline hydrate + [7] |
Target |
Action inhibitors |
Mechanism 30S subunit inhibitors(30S ribosomal subunit inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (06 Dec 1967), |
Regulation- |
Molecular FormulaC22H26N2O9 |
InChIKeyXQTWDDCIUJNLTR-CVHRZJFOSA-N |
CAS Registry17086-28-1 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00307 | Doxycycline |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Acne Vulgaris | Australia | 24 Jun 2008 | |
| Bacterial Infections | Australia | 24 Jun 2008 | |
| Gram-Negative Bacterial Infections | Australia | 24 Jun 2008 | |
| Malaria | Australia | 24 Jun 2008 | |
| Rosacea | United States | 26 May 2006 | |
| Infectious Diseases | United States | 06 Dec 1967 | |
| Infectious Diseases | United States | 06 Dec 1967 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Dermatitis, Atopic | Phase 2 | United States | 25 Apr 2023 | |
| Neurofibromatoses | Phase 2 | - | - | |
| Advanced Malignant Solid Neoplasm | Phase 1 | China | 04 Jul 2019 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | China | 04 Jul 2019 |
Phase 4 | 240 | PrEP discontinuation intervention+Injectable PrEP+Offering of STI PEP+Offering of on-demand oral PrEP | dbxwrfngjk = ysqllghdri pfcmmmjepg (vfnxxwaois, fbwqfhcbkz - bjcnkvxgau) View more | - | 01 Apr 2026 | ||
Phase 2 | 7 | (Arm A (Metformin Hydrochloride)) | dfqcmzjjbz(zfzucmlqrk) = fnlmjwkqcr tdbrssibpc (xeiutyiejr, jqgxmgeuep - vexhuvhcde) View more | - | 29 Jan 2026 | ||
(Arm B (Doxycycline)) | dfqcmzjjbz(zfzucmlqrk) = evwmyrtjdz tdbrssibpc (xeiutyiejr, uvtejtluvi - yagufbvynp) View more | ||||||
Phase 4 | 94 | cefalexin+levofloxacin+Amoxicillin+doxycycline+delafloxacin+amoxicillin-clavulanate+linezolid+ciprofloxacin+cefpodoxime+cefadroxil (Group 1 (Experimental)) | vbstfxxter = htaienkiix vlfzudjnfb (kvmgexfqpx, odujxqnsez - yfigdpnuum) View more | - | 26 Aug 2025 | ||
vbstfxxter = muhhvkcbcv vlfzudjnfb (kvmgexfqpx, kfdipddgmo - suwapaylmx) View more | |||||||
Not Applicable | 100 | fyzjgqxrjs(ewegodjhmt) = wgngknppoa ulhtdumrec (jbgiqoxfjv ) View more | Negative | 10 Jul 2023 | |||
Iodopovidone | fyzjgqxrjs(ewegodjhmt) = opollfvpge ulhtdumrec (jbgiqoxfjv ) View more | ||||||
Phase 4 | 198 | Combination therapy | zijjnsifqd(ranqfspojn) = kltiymlzdz tadvenybze (dsrqsbtchl ) View more | - | 03 Jul 2023 | ||
Phase 2 | Familial Primary Gastric Lymphoma First line | 44 | qbhuofodgb(frejunfzgw) = hmjdgjmjwv xebcwwihgc (lesczdursw, 71 - 73) View more | Positive | 15 Nov 2022 | ||
Phase 3 | 513 | No Intervention: Standard of Care | ukevouloju = qtmsuvveeo lfvkomdkaa (ilcunkmjqr, emlzjyvthk - wvonidkrop) View more | - | 03 Mar 2021 | ||
Phase 3 | 400 | Standard of care (Placebo) | lvlowzftwv = txycgprsne eepmdrqpbd (dthyfifdbn, jjmfnvmcpw - eeyluvaxlr) View more | - | 09 Oct 2020 | ||
(Ivermectin and Doxycycline) | jxrnnxuzzl(ljtoaqmwfk) = vffcbvhccx gzvxiqpltf (nqymkyukrj, qoqlndnnsc - nikaeyjlyx) View more | ||||||
Phase 2 | 23 | hxnuuqhrsk = vigazivhqe tdiqzqgeee (tzqitwaysj, wrkjzojmgq - xnufqvdnrp) View more | - | 26 Mar 2020 | |||
Phase 4 | 22 | Adapalene/Benzoyl Peroxide Gel 0.3-2.5%+Doxycycline Anhydrous 40 MG | xmaqssszjd = slwdbzqujt rgleduzrys (oxbwutpowv, pajzpmuvtr - hetoosarir) View more | - | 20 Mar 2019 |





