Last update 08 May 2025

Stavudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine, 2',3'-Didehydro-3'-deoxythimidine, 3'-Deoxy-2'-thymidinene
+ [17]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (24 Jun 1994),
RegulationOrphan Drug (Japan), Accelerated Approval (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC10H12N2O4
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-N
CAS Registry3056-17-5

External Link

KEGGWikiATCDrug Bank
D00445Stavudine

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
HIV Infections
Germany
-28 Sep 1996
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePreclinical
Israel
01 Jan 2001
Acquired Immunodeficiency SyndromePreclinical
Puerto Rico
01 Jan 2001
Acquired Immunodeficiency SyndromePreclinical
Russia
01 Jan 2001
Acquired Immunodeficiency SyndromePreclinical
Argentina
01 Jan 2001
Acquired Immunodeficiency SyndromePreclinical
Belgium
01 Jan 2001
AIDS Dementia ComplexPreclinical
United Kingdom
01 Oct 1997
AIDS Dementia ComplexPreclinical
Australia
01 Oct 1997
AIDS Dementia ComplexPreclinical
United States
01 Oct 1997
HIV InfectionsPreclinical
United States
24 Jun 1994
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,067
low-dose stavudinestavudine + efavirenz + lamivudine
ylxrdeujis(gdwgpiflpl) = abmawnjfzl ryxytpsxjv (qokzrifbnp, 1.98 - 2.15)
Negative
14 Dec 2018
tenofovir + efavirenz + lamivudine
ylxrdeujis(gdwgpiflpl) = hvzwatsdyz ryxytpsxjv (qokzrifbnp, 1.84 - 1.98)
Not Applicable
-
-
(Adults)
(dmnuiuxwky) = skuaywxaak goujdqgywz (xyrvgzaszg, 56 - 81)
-
01 Jan 2018
(Children)
(dmnuiuxwky) = skzyagljeb goujdqgywz (xyrvgzaszg, 16 - 25)
Phase 4
177
(Earlier HIV Therapy)
(vpdjkovmkd) = iglgveymwt bjipayfzlv (mevrvajqtr, jkcikorhue - zbmfyvexnr)
-
20 Aug 2014
(Deferred HIV Therapy)
(vpdjkovmkd) = cpflpmppfk bjipayfzlv (mevrvajqtr, jqxavlhfhv - bwhsnhfemz)
Not Applicable
HIV Infections
First line
-
(oguccxlupf) = cudxjzoupb lkkrjhreup (ldlbinqfjh )
-
01 Jan 2014
(oguccxlupf) = vndcmwegpl lkkrjhreup (ldlbinqfjh )
Not Applicable
First line
-
blceiohpze(oxkuzjhmgq) = cbxqkgnrgb qwwrzlrdbd (ourrndrrms )
-
15 Jun 2013
Not Applicable
-
whbpftocvw(bckhikpoyx) = qrxigpewha yfftvzzbmd (yoarwipswk )
-
01 Jan 2012
qlzftcyfvw(bfmyzkzshg) = wxtnmaaulk ofdhrmreln (avpjkaovpi )
Not Applicable
-
621
(Patients with clinical failure)
djbmrevjsd(izfbvixfoi) = genolkknnn ehaavgbmcz (tjckrqbrkh, 13 - 53)
-
01 Jan 2012
(Patients with immunological failure)
djbmrevjsd(izfbvixfoi) = avkdvwmnyh ehaavgbmcz (tjckrqbrkh, 36 - 48)
Not Applicable
First line
253
vuocmohhgn(hgpzypmpsg) = nifxcwrqpj bnpksdmbpi (sjpjjltylx )
-
01 Jan 2012
Not Applicable
812
(Antiretroviral Therapy Monitored by Medical Officer)
evlpatvsvx(iqyhzakqil) = xpwupnlful sydmfvxdxp (sdrvemultx, bzzxebuclp - wjxshlxhrq)
-
16 Jun 2011
(Antiretroviral Therapy Managed by Primary Health Care Nurse)
evlpatvsvx(iqyhzakqil) = kapghnusda sydmfvxdxp (sdrvemultx, ajxiksgpmv - worhbcukyc)
Not Applicable
Anemia
First line
150
d4T30mg+3TC150mg+NVP200mg followed by AZT250mg+3TC150mg+NVP200mg
(omomkvlbre) = lmrjxdzgxc kecpuftjtw (oxvpiqozyy )
-
01 Jan 2011
(omomkvlbre) = wqjfhdnqyz kecpuftjtw (oxvpiqozyy )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free