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The single-use plastic packaging for traditional Chinese herbal decoction is prevalent for its convenience. However, concerns have been raised regarding the biosafety implications of dissolved plastic particles from such food contact materials and their potential impact on drug efficacy. To initially investigate the release characteristics of micro/nanoplastics (M/NPs) from Chinese herbal decoction packages under different usage scenarios, 100 mL of water was filled at temperatures ranging from 40 ℃ to 100 ℃ and stored at 4 ℃ for 1 to 14 days before reheating at 60 ℃ prior to consumption. Fluorescence microscopy and nano flow cytometry revealed that one package could release 0.15-1.21 million MPs (over 60 % of MPs < 2 µm) and 0.48-4.32 billion NPs (over 40 % of NPs < 100 nm). The quantity of MPs decreased while NPs increased with higher filling temperatures, peaking after one day and seven days respectively. Exposure modeling estimated a daily intake of 2115-17,300 MPs/kg·day and 6.90-61.68 million NPs/kg·day from consuming one dose of Chinese herbal decoction. Furthermore, exposure of RAW264.7 cells to these plastic particles resulted in elevated levels of ROS and IL-6, aligning with dissolved NPs concentration trends. These findings cause apprehensions when utilizing plastic food packages due to M/NPs releases and potential proinflammatory risks.

Soil is an important sink for microplastics (MPs) and pesticides. MPs can act as carriers for pesticides, thus induce direct and indirect effects on soil organisms. Fluindapyr (FIP), a novel succinate dehydrogenase inhibitors fungicides (SDHIs), may pose a serious threat to earthworms. However, few studies have evaluated the effects of joint exposure to MPs and FIP. Here, earthworms (Eisenia fetida) were jointly exposed to PMMA (polymethylmethacrylate) and PS (polystyrene) MPs of different sizes (0.1, 1 and 10 μm) along with FIP for 28-day to investigate the toxic effects of single and joint exposure of FIP and MPs on earthworms. The results showed that joint exposure to 0.1 and 1 μm MPs promoted the accumulation of FIP in earthworms at the beginning of the experiment compared to the sole group, but the elimination of FIP from earthworms accelerated after 14 d. In addition, the joint exposure caused more serious damages to the epidermis and intestine of earthworms and increased the severity of oxidative stress. The effects of joint exposure to FIP and MPs depended on the size of the MPs, and the strongest effects were observed in the treatment with the smallest size. The 16S rRNA sequencing results showed that the joint exposure to MPs and FIP didn't cause gut microbiota dysbiosis. However, the sole 0.1 μm PS significantly altered the community diversity and richness of earthworm gut bacteria, and the relative abundance of Proteobacteria, Actinobacteria and Firmicutes was significantly changed. The obtained results inferred that MPs could influence environmental and toxicological behaviors of FIP and may provide data support for the risk assessments of MPs and FIP on soil ecosystems.