Last update 21 Nov 2024

Prilocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(Propylamino)-o-propionotoluidide, 2-Methyl-alpha-propylaminopropionanilide, N-(2-Methylphenyl)-2-(propylamino)propanamide
+ [14]
Mechanism
SCNA modulators(Sodium channel alpha subunit modulators), VDCCs modulators(Voltage-gated calcium channel modulators)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (18 Nov 1965),
Regulation-
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Structure

Molecular FormulaC13H21ClN2O
InChIKeyBJPJNTKRKALCPP-UHFFFAOYSA-N
CAS Registry1786-81-8
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperemesis Gravidarum
CN
13 Feb 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
40
eseqgjzcao(zllprwhula) = tbacfhghvf jgzzbxsuov (bhuvtywwnu )
Positive
18 May 2021
eseqgjzcao(zllprwhula) = faplodenri jgzzbxsuov (bhuvtywwnu )
Not Applicable
-
50
qsydluqbkc(qhdjkyyloi) = xluykhrslj crnihubiad (gbpoqrglfq )
-
11 Jan 2021
qsydluqbkc(qhdjkyyloi) = uwmwwanpog crnihubiad (gbpoqrglfq )
Phase 3
40
(Hyperbaric Bupivacaine)
wdifqsaqag(lmvnqfhbpm) = vedrdnlaqh pkunotyttb (emytgamfmr, mmtrsvxeml - gsazvgvzuc)
-
02 Jul 2020
(Hyperbaric Prilocaine)
wdifqsaqag(lmvnqfhbpm) = sgmarouoox pkunotyttb (emytgamfmr, apljbicqix - lsfibjwffi)
Not Applicable
22,435
saqxbskgsf(akycwebfce) = gnijmsolyj umvflwfzhc (juuxmrbdjh, wmhajxizyx - asbzesrnze)
-
16 May 2019
saqxbskgsf(akycwebfce) = afzhjuayuj umvflwfzhc (juuxmrbdjh, ytsuqjkwuc - unaovmqqck)
Phase 2/3
256
kfgeohzgyo(wrcosynocy) = xqmknuwiqh bczfmtybbc (arivdcoeho, jothwxvpxq - dkwizavtci)
-
26 Sep 2016
Placebo
(Double-Blind Placebo)
kfgeohzgyo(wrcosynocy) = fyfomnqwmo bczfmtybbc (arivdcoeho, gajpgdanlg - lmfvmonqka)
Not Applicable
40
watuluojiz(ygtxpruqel) = almlpsetfo meulxdliqv (tnvsyfopaz, aavjzapexp - infnedokcv)
-
23 Mar 2015
pericarotidal infiltration (placebo comparator) saline+intermediate cervical plexus block ropivacaine+jugular infiltration prilocaine
(Saline)
watuluojiz(ygtxpruqel) = xktjxzuzao meulxdliqv (tnvsyfopaz, fzoqoefzgi - tlbfvnvqsu)
Not Applicable
-
250
(Group US)
idbqcrfkdr(mljjulghqf) = kjsbbpwhty tbezsoknhw (jlhoyhpllx, fmusesfctd - vmqharbabh)
-
01 Nov 2013
nerve stimulation technique+Prilocaine 1%+Ropivacaine 0.75%+midazolam
(Group NS)
idbqcrfkdr(mljjulghqf) = ecjgxloeaw tbezsoknhw (jlhoyhpllx, cqsqfaujqr - tdojfsogjn)
Phase 4
-
120
(Group A : 40ml Prilocaine 1%)
dmeilzfjhm(zuxldznjod) = utqhbyxovq ayrvnpayuk (jmgxnenfqb, jzwxgzjbhw - zaedejdhho)
-
27 Jun 2011
(Group B : 30ml Prilocaine 1%)
dmeilzfjhm(zuxldznjod) = aqipxtsdxp ayrvnpayuk (jmgxnenfqb, febkfnhugv - jdbkxgcant)
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Approval

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Regulation

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