Delving into the Latest Updates on Levobupivacaine Hydrochloride with Synapse

Urolithin A (UroA) is well-recognized for its anti-oxidative, anti-inflammatory, and immunomodulatory potentials and has been proven to have neuroprotective effects. Nevertheless, the potential of UroA on bupivacaine (BUP)-induced neurotoxicity has never been reported. Using SH-SY5Y cells to establish a cell model, it was revealed that BUP stimulated cell viability reduction, LDH release increase, and suppression of SIRT1-activated PI3K/AKT signaling in SH-SY5Y cells, whereas UroA treatment caused an effective abrogation of the effects of BUP. Besides, SIRT1 overexpression caused an enhancement in the activity of PI3K/AKT signaling in BUP and UroA co-treated cells, indicating that SIRT1 mediated the activity of PI3K/AKT signaling. Moreover, UroA inhibited BUP-induced apoptosis, oxidative stress, and inflammatory responses in SH-SY5Y cells. However, the effects of UroA on BUP-induced neurotoxicity were all abated by inhibiting SIRT1 or PI3K/AKT signaling through EX527 or LY294002. In conclusion, UroA protected SH-SY5Y cells against BUP-induced injuries through PI3K/AKT signaling in a SIRT1-dependent manner.

01 Nov 2024·Research in Veterinary Science

Comparison of intra and postoperative analgesia efficacy of intraperitoneal levobupivacaine alone or in combination with dexmedetomidine in cats undergoing ovariohysterectomy; a randomized, prospective, blinded, clinical trial

Article

Author: Elban, Şaab ; Aydin, Şifanur ; Çiplak, Alper Yasin ; Tohumcu, Vefa ; Bedir, Ayşe Gölgeli ; Orhun, Ömer Tarık ; Okur, Damla Tuğçe ; Okur, Sıtkıcan

This study aimed to compare the analgesic and cardiopulmonary effects of levobupivacaine with or without dexmedetomidine, in cats undergoing ovariohysterectomy. In this prospective, randomized, and blinded clinical trial, 24 healthy cats were recruited. Animals received either saline (S group; 2 mL NaCl), levobupivacaine alone (Lev; 0.35 mg/kg), or levobupivacaine with dexmedetomidine (LevDex group; 0.004 mg/kg), which was infiltrated intraoperatively into the subcutaneous tissue at various incision sites, including the right and left ovarian pedicles and the caudal aspect of the uterine body. Intraoperative analgesia was evaluated using a cumulative pain scale, while postoperative analgesia was assessed at various time points: before surgery (T_b), and at 0 (T₀), 1 (T_1h), 2 (T_2h), 4 (T_4h), 8 (T_8h), 12 (T_12h), and 24 (T_24h) hours after the procedure, using the UNESP-Botucatu multidimensional composite pain scale (MCPS). Significant decreases in heart rate, respiratory rate, and mean arterial pressure were observed in LevDex group as compared to S and Lev groups (p < 0.05). The S group required significantly more rescue morphine doses than the LevDex group (p = 0.029), but the difference was not significant when compared to the Lev group (p = 0.123). At T_1h and T_2h, the S group had significantly higher MCPS scores than both the Lev and LevDex groups (p = 0.029). However, at T_8h, no significant difference was found between the S and LevDex groups (p = 0.741). While adding dexmedetomidine to levobupivacaine may slightly prolong postoperative analgesia, this combination does not provide significant additional benefit over levobupivacaine alone in terms of response to surgical stimulation.

01 Nov 2024·Journal of Perioperative Practice

Add dexmedetomidine to levobupivacaine for transversus abdominis plane block in elderly patients undergoing inguinal hernia repair: Could it make a difference? A randomised trial

Article

Author: Ali, Wesam Nashat ; Ali, Ahmed Mohammed ; Abo Elfadl, Ghada Mohammad ; Ahmed, Fatma Nabil ; Abd el-Rady, Nessren M ; Abdel Rady, Marwa Mahmoud

Background: Transversus abdominis plane block is becoming more common as part of multimodal analgesia for post-abdominal operation pain relief. This study compared the analgesic effects of adding dexmedetomidine to levobupivacaine (transversus abdominis plane) block in elderly patients undergoing inguinal hernia surgery to adding fentanyl. Methods: Overall, 90 elderly patients with a simple inguinal hernia repair were randomly assigned to one of three groups. After spinal anaesthesia, an ultrasound-guided transversus abdominis plane block was performed. Transversus abdominis plane block was accomplished with 0.25% levobupivacaine + 0.9% normal saline in Group L (n = 30) (20mL). Transversus abdominis plane block was accomplished with 0.25% levobupivacaine + 1 µg/kg dexmedetomidine in Group D (n = 30) (20mL). Transversus abdominis plane block was obtained with 0.25% levobupivacaine + 1 µg/kg fentanyl in Group F (n = 30) (20mL). The primary outcome was the first analgesic request, and the secondary outcomes were the visual analog scale, postoperative analgesic requirements, sedation, hemodynamic stability, and related complications 24 hours postoperatively. 1gm paracetamol intravenously was provided as rescue analgesia. Results: The time to first analgesic request in the dexmedetomidine group was substantially more prolonged than in the fentanyl and control groups (516.5±27.8, 451.2±11.1, and 403.9±10.5min, respectively; p < 0.05). Postoperative analgesic requirements were significantly decreased in dexmedetomidine 1(1-2) than control 2(1-3) and fentanyl 1.5(1-2) respectively (P<0.01). VAS was significantly lower in Group D and Group F than in Group L postoperatively. No significant difference in side effects was noted between the groups. Conclusion: The transversus abdominis plane block is the best multimodal analgesia choice for inguinal hernia repair in older patients. Combining dexmedetomidine with levobupivacaine in the transversus abdominis plane block can improve the quality of postoperative analgesia while avoiding significant side effects.

100 Deals associated with Levobupivacaine Hydrochloride

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KEGG	Wiki	ATC	Drug Bank
D01287	Levobupivacaine Hydrochloride	N01BB10	DB01002

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anesthesia	CN	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	16 Oct 2002

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Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04773301 (CTgov)	Phase 4	Hip Fractures	114	Levobupivacaine (LEVOBUPIVACAINE)	ubqxtjvkrk(tgfbidaiml) = wfnjsijhrl hqcsnktgea (flifkkfvuw, ilxwejostb - odzflxhedm) View more	-	19 Jul 2024
				ropivacaine (ROPIVACAINE)	ubqxtjvkrk(tgfbidaiml) = dlrjcjhmsz hqcsnktgea (flifkkfvuw, urkeekchwj - jiybjgivsj) View more
NCT04003987 (CTgov)	Phase 3	-	78	bupivacaine, 0.125%+Liposomal bupivacaine (ESP Block)	woxkqutuym(kxonlgoyfv) = rumplafgqw bndxjpdblz (njyrltwxcz, krgyqhfitb - lpgroojgsk) View more	-	05 Jul 2022
				bupivacaine, 0.125%+Liposomal bupivacaine (TAP Block)	woxkqutuym(kxonlgoyfv) = lnkeqoyrmw bndxjpdblz (njyrltwxcz, vncoylgwwz - aozcdigoot) View more
NCT01458431 (Pubmed \| Anesth Analg)	Phase 3	-	70	0.35% Levobupivacaine	dxirwzlrxc(uxxguastcy) = jgncqjuedj bysqcdtocb (iascglpaea, 18.5 - 80) View more	Positive	27 Jan 2022
				Saline	dxirwzlrxc(uxxguastcy) = snysaneuyi bysqcdtocb (iascglpaea, 39.0 - 136) View more
AAIC2021	Not Applicable	Alzheimer Disease	174	NeuroEPO 0.5 mg	-	Positive	31 Dec 2021
				NeuroEPO 1.0 mg
Pubmed \| Minerva Anestesiol	Not Applicable	Femoral Neck Fractures	-	0.5% isobaric bupivacaine with 20mcg of fentanyl	apbnoeoonj(kjfzilotzt) = ngnifmmcpa zzzxglvwph (jsskukdpfq, (1.45mg)) View more	-	16 Feb 2021
NCT02848599 (CTgov)	Phase 2	Femoral Fractures \| Systemic Inflammatory Response Syndrome \| postoperative cognitive dysfunction \| Pain, Postoperative	86	morphine (Morphine)	pknovbwidm(azsckosylx) = xunjsbcgwi rzoteuxknt (ufrbfwazaw, dzotdkcbku - qbaypcgfeb) View more	-	01 Sep 2020
				levobupivacaine (Levobupivacaine)	pknovbwidm(azsckosylx) = glycfisgay rzoteuxknt (ufrbfwazaw, nuvyhanqwc - kyymefxiei) View more
Pubmed \| Anesth Analg	Not Applicable	-	-	Placebo	lixsqbyeeb(eascnkkcha) = dfxlbbnhqz atukhysvbd (eqvzrqyujm )	-	25 Jun 2020
				Low-dose dexmedetomidine 0.2 μg·kg	lixsqbyeeb(eascnkkcha) = fpskxplrvh atukhysvbd (eqvzrqyujm )
NCT01991743 (CTgov)	Not Applicable	Pregnancy \| Pain	240	Group 2.5 (Drug:Group 2.5)	erczgzwuvv(hvwfvyiuvc) = lpjwskfttr kmrioqvwyq (ofvvcixmit, pjbnrishpl - hmfvmolafn) View more	-	06 Jan 2020
				Group 5 (Group 5)	erczgzwuvv(hvwfvyiuvc) = cdbahlmaaa kmrioqvwyq (ofvvcixmit, dqtiukyiow - shlzayitxu) View more
NCT02726620 (CTgov)	Not Applicable	Hypotension	22,435	Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group)	esmcbpkmey(zqtrxxvrmm) = jffopxpqvk amaxvkpeen (bjcfczwvyj, bukfihnxpi - dxljslovzr) View more	-	16 May 2019
				Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support)	esmcbpkmey(zqtrxxvrmm) = jkcegviksb amaxvkpeen (bjcfczwvyj, opdrvmwccc - yyefaowpdr) View more
NCT01172197 (CTgov)	Phase 4	Neurolytic Block \| Pain	14	Levobupivacaine (Ropivacaine)	lxwhegexng(wbcbuwchvr) = rzvavpqmav vndyytztgg (uraujzxsah, lmkuqqtdnq - pdntkrukvz) View more	-	09 May 2018
				ropivacaine (Levobupivacaine)	lxwhegexng(wbcbuwchvr) = xmjqkagdnu vndyytztgg (uraujzxsah, nxicbabcuv - dhjonyjawz) View more